Do bacteria have a role in asthma development?

Armann, Jakob

doi:10.1183/09031936.00041410

Cited by 13 publications

(13 citation statements)

References 22 publications

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“…However, a number of recent papers have demonstrated that a range of organisms are present in the healthy lung but are more common in COPD or asthma. 26,27 There is clearly growing interest in the role of infective organisms in asthma, but their role and significance is still unclear. However, it is possible to speculate that the protease enzymes that protozoa produce could act in the same way as Der P1 to breakdown the tight junctions between epithelial cells, increase the shedding of epithelial cells in the respiratory tract, and facilitate the penetration of allergens into local tissues.…”

Section: Discussionmentioning

confidence: 99%

Association between protozoa in sputum and asthma: A case-control study

Woerden

Ratier-Cruz²,

Aleshinloye³

et al. 2011

Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Association between protozoa in sputum and asthma: A case-control study

Woerden

Ratier-Cruz²,

Aleshinloye³

et al. 2011

Respiratory Medicine

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“…Hygiene (a reduced exposure to microbial agents) has been considered as one of the most relevant factors associated with the raising trend of asthma and allergies. The ‘hygiene hypothesis’ has been supported by a multitude of epidemiological studies , providing evidence for the beneficial as well as harmful effect of viral and bacterial infections , microbial stimulation , larger sibships, day care attendance , and farming environment in the development of atopy and asthma.…”

Section: Hygiene and Infectionsmentioning

confidence: 99%

Allergic airway diseases in childhood – marching from epidemiology to novel concepts of prevention

Hatzler

Hofmaier

Papadopoulos

2012

Pediatric Allergy Immunology

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In the past years, a wide range of epidemiological, clinical, and experimental studies have produced remarkable advances in the field of respiratory allergies in childhood. By the recent investigations on epidemiological trends, risk factors, and prevention of asthma and allergic rhinitis, various exiting concepts have been challenged, and novel innovative approaches have been developed. Pediatric Allergy and Immunology (PAI), with a number of highly relevant contributions between 2010 and 2012, has become an important forum in this area. The prevalence of asthma in some developed countries may have reached a plateau, while in developing countries, where the prevalence was previously low, allergic diseases are still on the increase. A wide array of risk and protective factors, including hygiene, infections, outdoor and indoor air pollution, allergen exposure, breast-feeding practices, nutrition, and obesity, play a multifaceted role in shaping the observed worldwide trends of respiratory allergies. Under the guidance of recent research, prediction and prevention strategies in the clinical practice are progressively changing, the focus moving away from avoidance of allergen exposure and toward tolerance induction.

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“…Approximately 20% of wheezing children have serological evidence of an immune response to Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarralis [9,10] . More recently, Mycoplasma pneumoniae and Chlamydia pneumoniae have been identified in 5–25% of children with asthma exacerbations [11-13].…”

Section: Introductionmentioning

confidence: 99%

The prevalence and identity of Chlamydia -specific IgE in children with asthma and other chronic respiratory symptoms

et al. 2012

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BackgroundRecent studies have confirmed the presence of viable Chlamydia in the bronchoalveolar lavage (BAL) fluid of pediatric patients with airway hyperresponsiveness. While specific IgG and IgM responses to C. pneumoniae are well described, the response and potential contribution of Ag-specific IgE are not known. The current study sought to determine if infection with Chlamydia triggers the production of pathogen-specific IgE in children with chronic respiratory diseases which might contribute to inflammation and pathology.MethodsWe obtained BAL fluid and serum from pediatric respiratory disease patients who were generally unresponsive to corticosteroid treatment as well as sera from age-matched control patients who saw their doctor for wellness checkups. Chlamydia-specific IgE was isolated from BAL and serum samples and their specificity determined by Western blot techniques. The presence of Chlamydia was confirmed by species-specific PCR and BAL culture assays.ResultsChlamydial DNA was detected in the BAL fluid of 134/197 (68%) patients. Total IgE increased with age until 15 years old and then decreased. Chlamydia-specific IgE was detected in the serum and/or BAL of 107/197 (54%) patients suffering from chronic respiratory disease, but in none of the 35 healthy control sera (p < 0.0001). Of the 74 BAL culture-positive patients, 68 (91.9%, p = 0.0001) tested positive for Chlamydia-specific IgE. Asthmatic patients had significantly higher IgE levels compared to non-asthmatics (p = 0.0001). Patients who were positive for Chlamydia DNA or culture had significantly higher levels of serum IgE compared to negative patients (p = 0.0071 and p = 0.0001 respectively). Only 6 chlamydial antigens induced Chlamydia-specific IgE and patients with C. pneumoniae-specific IgE had significantly greater levels of total IgE compared to C. pneumoniae-specific IgE negative ones (p = 0.0001).ConclusionsIgE antibodies play a central role in allergic inflammation; therefore production of Chlamydia-specific IgE may prove significant in the exacerbation of chronic, allergic airway diseases, thus highlighting a direct role for Chlamydia in asthma pathogenesis.

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Do bacteria have a role in asthma development?

Cited by 13 publications

References 22 publications

Association between protozoa in sputum and asthma: A case-control study

Association between protozoa in sputum and asthma: A case-control study

Allergic airway diseases in childhood – marching from epidemiology to novel concepts of prevention

The prevalence and identity of Chlamydia -specific IgE in children with asthma and other chronic respiratory symptoms

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