Do BRCA1 mutations affect the ability to breast-feed? Significantly shorter length of breast-feeding among BRCA1 mutation carriers compared with their unaffected relatives

Jernström, Helena; Jóhannsson, Óskar Þór; Borg, Åke; Olsson, Håkan

doi:10.1016/s0960-9776(98)90074-1

Cited by 21 publications

(19 citation statements)

References 18 publications

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“…Breast-feeding duration appears to be shorter among BRCA1 mutation carriers than among non-carriers [20] or BRCA2 carriers [21]. A high proportion of BRCA1 mutation carriers cited poor milk production as the main reason for early weaning compared with female relatives who did not carry a BRCA1 mutation [20]. The protection from breast cancer conferred by a long breast-feeding duration ([1 year) seems to be much greater for women with BRCA1 mutations than for women in the general population (approximately 45% vs. 4%) [21][22][23].…”

Section: Introductionmentioning

confidence: 88%

“…It is possible that the impaired differentiation of breasts during pregnancy, seen in women with a family history of breast cancer, may also affect milk production and the ability to breast-feed. Breast-feeding duration appears to be shorter among BRCA1 mutation carriers than among non-carriers [20] or BRCA2 carriers [21]. A high proportion of BRCA1 mutation carriers cited poor milk production as the main reason for early weaning compared with female relatives who did not carry a BRCA1 mutation [20].…”

Section: Introductionmentioning

confidence: 91%

“…1 shows prolactin levels obtained during menstrual cycle days 5-10 after onset of the menstrual period in 120 parous women, not currently breast-feeding, in relation to time of blood draw and breastfeeding duration of their first child. Breast-feeding duration was divided into four categories and there was a significant trend between a longer duration of breast-feeding and lower prolactin levels (P trend = 0.016, adjusted for time of blood draw) Table 2 The self-reported milk production among women \25 years-old and C25 years-old at the first full-term pregnancy Too much milk 31 (24) 18 (28) 13 (20) A total of 128 women answered the question. Information was missing for one women\25 years-old and one women C25 years-old at the first full-term pregnancy.…”

Section: Milk Production In Relation To Age At First Full-term Pregnamentioning

confidence: 99%

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Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk

2007

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High prolactin levels have been associated with increased breast cancer risk. Prolactin is essential for breast-feeding. Prolactin is lowered primarily by the first full-term pregnancy and not by subsequent pregnancies. The protection from breast cancer conferred by a long breast-feeding duration (>1 year) seems to be much greater for women with BRCA1 mutations (45%) than for women in the general population (4%). One study reported poor milk production to be more common in BRCA1 carriers (75%) than in non-carriers (36%). We aimed to explore the relationships between prolactin levels, breast-feeding duration, milk production and BRCA carrier status in young healthy women from high-risk breast cancer families. Questionnaires including information on reproductive factors and lifestyle were completed by 269 healthy women, aged 40 years or younger. Body measurements and plasma prolactin levels were obtained during cycle days 5-10 and 18-23. Prolactin was higher in nulliparous than in parous women (P < 0.0001). In parous women, post-lactational prolactin levels in both cycle phases were significantly negatively associated with breast-feeding duration of the first child (P < or = 0.009), but not with additional breast-feeding of subsequent children (P > or = 0.12). Prolactin was higher in women who reported insufficient versus sufficient milk production (P < or = 0.01). Neither BRCA1/2 carrier status nor increasing parity was significantly associated with prolactin, breast-feeding duration of the first child or milk production. In conclusion, post-lactational prolactin levels were determined by breast-feeding duration of the first child and not simply by the first full-term pregnancy. Since prolactin modifies the risk for breast cancer, adequate counseling in favor of breast-feeding is essential.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 91%

Section: Milk Production In Relation To Age At First Full-term Pregnamentioning

confidence: 99%

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Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk

2007

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“…Disruption of the breast cancer susceptibility gene BRCA1 results in defects in mammary epithelial differentiation in vitro (Kubista et al, 2002;Furuta et al, 2005) and defective lobular-alveolar development in the mammary gland in vivo, based on analysis of breast tissue from BRCA1 mutation carriers or mice in which the Brca1 gene has been deleted from the mammary gland or in which the mammary gland expresses a dominant-negative Brca1 mutant (Jernstrom et al, 1998;Xu et al, 1999;Russo et al, 2001;Brown et al, 2002;Triplett et al, 2008). Tumours arising in BRCA1 mutation carriers and Brca1 conditional knockout mice have a distinct histopathological and molecular phenotype, including high grade, high mitotic index and expression of basal and stem cell-associated genes (Lakhani et al, 1998;Sorlie et al, 2003;Liu et al, 2008;Shakya et al, 2008;Wright et al, 2008a, b).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

et al. 2010

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Disruption of the breast cancer susceptibility gene Brca1 results in defective lobular-alveolar development in the mammary gland and a predisposition to breast tumourigenesis in humans and in mice. Recent evidence suggests that BRCA1 loss in humans is associated with an expansion of the luminal progenitor cell compartment in the normal breast and tumours with a luminal progenitorlike expression profile. To further investigate the role of BRCA1 in the mammary gland, we examined the consequences of Brca1 loss in mouse mammary epithelial cells in vitro and in vivo. Here, we show that Brca1 loss is associated with defective morphogenesis of SCp2 and HC11 mouse mammary epithelial cell lines and that in the MMTV-Cre Brca1 Co/Co mouse model of Brca1 loss, there is an accumulation of luminal progenitor (CD61 þ CD29 lo CD24 þ ) cells during pregnancy. By day 1 of lactation, there are marked differences in the expression of 1379 genes, with most significantly altered pathways and networks, including lactation, the immune response and cancer. One of the most differentially expressed genes was the luminal progenitor marker, c-kit. Immunohistochemical analysis revealed that the increase in c-kit levels is associated with an increase in c-kit positivity. Interestingly, an inverse association between Brca1 and c-kit expression was also observed during mammary epithelial differentiation, and small interfering RNA-mediated knockdown of Brca1 resulted in a significant increase in c-kit mRNA levels. We found no evidence that c-kit plays a direct role in regulating differentiation of HC11 cells, suggesting that Brca1-mediated induction of c-kit probably contributes to Brca1-associated tumourigenesis via another cellular process, and that c-kit is likely to be a marker rather than a mediator of defective lobular-alveolar development resulting from Brca1 loss.

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“…One preliminary study showed a significantly lower expression of the progesterone receptor in the non-neoplastic mammary tissue from a small number of BRCA 1 and BRCA2 carriers 3 . Interestingly, recent data suggested physiological differences in BRCA 1 and BRCA2 carriers, such as a reduced period of lactation, when compared with women without mutations 4 . Moreover, contrary to what is observed in the general population, early pregnancy and multiparity are associated with an increased breast cancer risk in BRCA1 and BRCA2 mutation carriers 5 .…”

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confidence: 99%

Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations Normal"? - An Immuno-Histopathological Study"

Foulkes¹,

Alpert²,

Quenneville³

et al. 2003

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Do BRCA1 mutations affect the ability to breast-feed? Significantly shorter length of breast-feeding among BRCA1 mutation carriers compared with their unaffected relatives

Cited by 21 publications

References 18 publications

Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk

Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations Normal"? - An Immuno-Histopathological Study"

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