Do different treatment strategies influence women’s level of psychosexual distress? Observational cohort study of women with premalignant HPV-associated genital lesions

Nagele, Eva; Trutnovsky, Gerda; Greimel, Elfriede; Dorfer, Martha; Haas, Josef; Reich, Olaf

doi:10.1016/j.ejogrb.2019.03.028

Cited by 8 publications

(16 citation statements)

References 26 publications

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“…In terms of longer-term impact, sexual distress was found to persist at 6-months in two studies (Kwan et al, 2011;Maissi et al, 2005); one study examined the trajectory of adjustment to sexual distress over a 12-month period and found that adjustment occurred from one-to-6-months after HPV diagnosis (Hsu et al, 2018). Consistently, another study found no differences over a 12-month period (Nagele et al, 2019). General psychological distress (Golderberg & Williams, 1988) was found to be slightly higher (worse) in women testing HPV-positive with abnormal cytology 4-weeks after their result in two studies (Maissi et al, 2004;McBride et al, 2020).…”

Section: Quantitative (Distress)mentioning

confidence: 95%

“…General psychological distress (Golderberg & Williams, 1988) was found to be slightly higher (worse) in women testing HPV-positive with abnormal cytology 4-weeks after their result in two studies (Maissi et al, 2004;McBride et al, 2020). However, no differences were found 6-months later in a follow-up study (Maissi et al, 2005) or up to 12 or 24 months later in two other studies (Andreassen et al, 2019;Nagele et al, 2019). The Kitchener et al (2008) trial again had mixed findings for general distress.…”

Section: Quantitative (Distress)mentioning

confidence: 97%

“…Another study found that cervical cancer worry was higher in HPV-positive women shortly after result notification, but differences disappeared at 6-months (Kwan et al, 2011); and one study reported that worry about developing cervical cancer decreased over time (Ngu et al, 2018). During an observational period of 12 months (baseline, 6, 12 months) there were no significant differences in fear of disease progression (Nagele et al, 2019).…”

Section: Quantitative (Fear)mentioning

confidence: 99%

“…Seventeen papers were quantitative studies (Alay et al, 2019;Andreassen et al, 2019;Ferenidou et al, 2012;Garces-Palacio et al, 2019;Hsu et al, 2018;Kitchener et al, 2008;Kwan et al, 2011;Maggino et al, 2007;Maissi et al, 2004Maissi et al, , 2005McBride et al, 2020;McCaffery et al, 2004;Nagele et al, 2019;Ngu et al, 2018;Rodriguez et al, 2019;Wang et al, 2010;Wang et al, 2011), 15 were qualitative (Barrera-Clavijo et al, 2015;Barreto et al, 2016;Bertram & Magnussen, 2008;Head et al, 2017;Kosenko et al, 2012;Lin et al, 2011;Linde et al, 2019;McCaffery & Irwig, 2005;McCaffery et al, 2006;McCurdy et al, 2011;O'Connor et al, 2014;Perrin et al, 2006;Tiro et al (2019); Waller, McCaffery, et al, 2007;Wyndham-West et al, 2018) and one was mixed-methods (Daley et al, 2010). A total of 12,789 women aged between 18 and 65 participated in twenty studies (n=12,244 quantitative; n=545 qualitative), of whom 4,305 were reported as having tested positive for HPV (n=3,874 quantitative; n=431 qualitative).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Sixteen quantitative studies included a measure of psychological distress: ten included test-specific distress (Ferenidou et al, 2012;Garces-Palacio et al, 2019;Kwan et al, 2011;Maissi et al, 2004Maissi et al, , 2005McBride et al, 2020;McCaffery et al, 2004;Ngu et al, 2018;Wang et al, 2010Wang et al, , 2011, eleven sexual distress (Alay et al, 2019;Ferenidou et al, 2012;Hsu et al, 2018;Kitchener et al, 2008;Kwan et al, 2011;Maggino et al, 2007;Maissi et al, 2005;McCaffery et al, 2004;Nagele et al, 2019;Wang et al, 2010Wang et al, , 2011 and six general distress (Andreassen et al, 2019;Hsu et al, 2018;Kitchener et al, 2008;Maissi et al, 2004Maissi et al, , 2005McBride et al, 2020). Test-specific distress was consistently higher (worse) for women testing HPV-positive with any cytology result compared to normal results up to 6-months post-result (Maissi et al, 2005), but not at 12-months post-result (Garces-Palacio et al, 2019).…”

Section: Quantitative (Distress)mentioning

confidence: 99%

See 4 more Smart Citations

Emotional response to testing positive for human papillomavirus at cervical cancer screening: a mixed method systematic review with meta-analysis

McBride

Tatar

Rosberger

et al. 2020

Health Psychology Review

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Section: Quantitative (Distress)mentioning

confidence: 95%

Section: Quantitative (Distress)mentioning

confidence: 97%

Section: Quantitative (Fear)mentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Quantitative (Distress)mentioning

confidence: 99%

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Emotional response to testing positive for human papillomavirus at cervical cancer screening: a mixed method systematic review with meta-analysis

McBride

Tatar

Rosberger

et al. 2020

Health Psychology Review

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Aesthetic Outcome and Psychosexual Distress After Treatment for Vulvar High-Grade Squamous Intraepithelial Lesions

Trutnovsky,

Holter,

Gold

et al. 2023

J Low Genit Tract Dis

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Objectives This study compared aesthetic outcome, psychosexual distress, and treatment satisfaction between women receiving surgical treatment or medical treatment with imiquimod for vulvar high-grade squamous intraepithelial lesion. Materials and Methods This is an extended analysis of the multicenter, randomized noninferiority trial “topical imiquimod versus surgery for vulvar intraepithelial neoplasia.” Patients were randomized to primary topical treatment or surgery and stratified by unifocal or multifocal disease. Digital photos of vulvar appearance were subsequently assessed for aesthetic outcome by 3 investigators blinded to group allocation. Psychosexual distress and treatment satisfaction were assessed with the Cervical Dysplasia Distress Questionnaire, the Sexual Activity Questionnaire, and the Client Satisfaction Questionnaire at baseline and follow-up. Results One hundred ten patients aged between 19 and 82 years were enrolled. Per-protocol analysis showed complete clinical response in 80% (37/46) using imiquimod, compared with 79% (41/52) after one surgical intervention. Photodocumentation at baseline and 6-month follow-up was available for 84 of these patients (44 imiquimod, 40 surgery). Blinded reviewer assessments of lesion size and lesion severity showed improvement from baseline to follow-up, with no differences between treatment groups. Sexual pleasure, discomfort, and distress remained stable from baseline to follow-up in both groups. Conclusions Good aesthetic outcome of vulvar high-grade squamous intraepithelial lesion treatment can be achieved with imiquimod and surgery, consisting of ablation or local excision. Treatment satisfaction and stable psychosexual health may not be dependent on chosen treatment modality, but rather on counseling in accordance with patients’ preferences.

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Escala para avaliação da qualidade de vida de mulheres com infecção pelo Papilomavírus Humano - EQUALI-HPV (fase 2)

Caldeira¹

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Introdução: Os Papilomavírus Humano (HPV) são vírus capazes de infectar a pele ou as mucosas. Atualmente, existem 228 diferentes tipos, sendo 13 considerados oncogênicos. Trata-se de um vírus altamente contagioso com possibilidade de infecção com apenas uma exposição, sendo o contato sexual a principal via de transmissão. Mesmo constituindo a Infecção Sexualmente Transmissível (IST) mais comum, os cânceres relacionados à infecção pelo HPV não são comumente encontrados em homens. Por outro lado, nas mulheres, acarreta mais comumente danos físicos, psicológicos, afetivo/sexuais e sociais, impactando diretamente na Qualiade de Vida (QV). Considerando-se que no Brasil inexistem instrumentos específicos que avaliem a QV entre mulheres com HPV, a elaboração de uma ferramenta com esta finalidade é de grande relevância. Objetivo: Avaliar as propriedades psicométricas da Escala para avaliação da Qualidade de Vida de mulheres com infecção pelo HPV -EQUALI-HPV. Metodologia: Trata-se de um estudo metodológico. Foram entrevistadas mulheres com infecção pelo HPV em um ambulatório especializado. Além da versão 4 da EQUALI-HPV, foi aplicado um questionário com variáveis sociodemográficas e clínicas e também o Termo de Consentimento Livre e Escalrecido (TCLE). Os dados foram duplamente digitados e posteriormente validados no Microsoft® Office Excel for Windows. Para as análises estatísticas descritivas (Análise Fatorial Exploratória (AFE), alfa de Cronbach e efeitos floor e ceiling), utilizou-se o software Statistical Package for the Social Sciences (SPSS), 20.0; para a análise Multitraço-Multimétodo (MTMM) foi utilizado o Programa Multitraid Analysis Program (MAP), 2.0. Todos os aspectos éticos foram contemplados. Resultados: Foram entrevistadas 351 mulheres, com mediana de idade de 36,9 anos (DP= 11,9), com mínima de 18 e máxima de 79; destas, 162 (46,2%), afirmaram ser casadas e a maioria (85,5%) tinha renda de um a três salários mínimos. Após a exclusão dos itens relacionados à condilomatose e ao conhecimento, o modelo contendo 63 itens foi submetido à verificação das propriedades psicométricas. A AFE determinou que a melhor estrutura do modelo se deu com seis fatores. Neste momento, foram excluídos cinco itens por apresentarem carga fatorial ≤0,30. Em seguida, averiguou-se a fidedignidade pela análise da consistência interna por meio do alfa de Cronbach com resultado global de 0,883; nesta etapa foram excluídos outros quatro itens que comprometiam a fidedignidade. Realizou-se novamente a AFE com o objetivo de verificar a variância explicada após a exclusão dos itens, obtendo-se o valor de 51,9%. Após, foram averiguadas as presenças dos efeitos floor e ceiling, no domínio "Reações ao exame clínico" e o efeito ceiling na dimensão "Relações sociais, familiares e de trabalho" (51,6%). Na validade de construto convergente 94,4% dos itens apresentaram correlações moderadas ou muito fortes; na validade de construto divergente os domínios do instrumento apresentaram ajuste de 100% com exceção do domínio 5 que foi de 98,0%. Conclusão...

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Do different treatment strategies influence women’s level of psychosexual distress? Observational cohort study of women with premalignant HPV-associated genital lesions

Cited by 8 publications

References 26 publications

Emotional response to testing positive for human papillomavirus at cervical cancer screening: a mixed method systematic review with meta-analysis

Emotional response to testing positive for human papillomavirus at cervical cancer screening: a mixed method systematic review with meta-analysis

Aesthetic Outcome and Psychosexual Distress After Treatment for Vulvar High-Grade Squamous Intraepithelial Lesions

Escala para avaliação da qualidade de vida de mulheres com infecção pelo Papilomavírus Humano - EQUALI-HPV (fase 2)

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