Do euthymic bipolar patients have normal cognitive functioning?

Jamrozinski, Katja

doi:10.1097/yco.0b013e328338620a

Cited by 16 publications

(14 citation statements)

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“…Severe impairment is evident in those who have an early onset of illness and particularly the onset during childhood or adolescence. 17 We also observed no significant correlation between numbers of depressive episode and neurocognitive decline. Concurrent to present findings, in the systematic treatment optimization programme for early mania (STOP-EM) study, depressive episodes did not impart any additional burden on cognitive function.…”

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confidence: 55%

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

et al. 2017

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Background: Bipolar patients often suffer from debilitating cognitive impairment in different stages of the disease (manic, depressive or euthymic states). We assessed and compared the frequency of neurocognitive deficit among individual with bipolar I disorder but currently in euthymic state, their first-degree blood relatives and healthy controls. In addition, we also probed further into the type of neurocognitive deficit that can be seen among them and observed the influence of sociodemographic characteristics with the occurrence of neurocognitive deficit in individual with bipolar I disorder patient.Methods: Patients (N=30) who fulfilled the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV TR) criteria for bipolar I disorder but currently in remission were assessed for any neurological deficits using the standard instruments. In this study, 30 first-degree blood relatives of bipolar I disorder patients and selected 30 hospital staff as healthy controls were also assessed for neurological deficits.Results: We did not find any significant frontal dysfunction among first-degree blood relatives of bipolar I disorder patient when compared with euthymic bipolar I disorder patients. Factor that significantly affected neurocognitive performance in the bipolar patients who were in euthymic state included age, total duration of illness and number of manic episode.Conclusions: As neurocognitive impairment is associated with number of manic episode and total duration of illness; the objective of treatment should be to prolong remission and impart psychoeducation regarding nature of illness. On the contrary, anticipating definite cognitive impairment in first-degree blood relatives of bipolar I disorder patient when compared to healthy control warrants periodic neurocognitive testing and psychoeducation about deficit and medical intervention, if required.

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confidence: 55%

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

et al. 2017

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“…Based on these previous findings, it may be inferred that BMI contributes to decreased cognitive functioning in euthymic individuals with BD. It is well established that impairments in executive function are apparent in mixed populations of individuals with BD as well as obese individuals without psychiatric disorders [7,10,16,19,22,26,27,28,41,45]. It could be hypothesized that obesity and BD are associated with common central nervous system structural and/ or functional changes in brain regions that subserve cognitive functioning.…”

Section: Discussionmentioning

confidence: 99%

“…Fourthly, there was no attempt to ''enrich'' the sample for individuals who have cognitive deficits. As a result, considerable heterogeneity in cognitive profiles was observed, which may have also decreased the likelihood of detecting an association [22] Fifthly, we did not have detailed information regarding the duration of overweight/obesity. Studies in non-psychiatric populations indicate that the adverse effect of overweight/obesity may be duration-dependent [19].…”

Section: Discussionmentioning

confidence: 99%

The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder

et al. 2012

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BackgroundPersistent impairment in cognitive function has been described in euthymic individuals with bipolar disorder. Collective work indicates that obesity is associated with reduced cognitive function in otherwise healthy individuals. This sub-group post-hoc analysis preliminarily explores and examines the association between overweight/obesity and cognitive function in euthymic individuals with bipolar disorder.MethodsEuthymic adults with DSM-IV-TR-defined bipolar I or II disorder were enrolled. Subjects included in this post-hoc analysis (n = 67) were divided into two groups (normal weight, body mass index [BMI] of 18.5–24.9kg/m2; overweight/obese, BMI≥25.0kg/m2). Demographic and clinical information were obtained at screening. At baseline, study participants completed a comprehensive cognitive battery to assess premorbid IQ, verbal learning and memory, attention and psychomotor processing speed, executive function, general intellectual abilities, recollection and habit memory, as well as self-perceptions of cognitive failures.ResultsBMI was negatively correlated with attention and psychomotor processing speed as measured by the Digit Symbol Substitution Test (P<0.01). Overweight and obese bipolar individuals had a significantly lower score on the Verbal Fluency Test when compared to normal weight subjects (P<0.05). For all other measures of cognitive function, non-significant trends suggesting a negative association with BMI were observed, with the exception of measures of executive function (i.e. Trail Making Test B) and recollection memory (i.e. process-dissociation task).ConclusionNotwithstanding the post-hoc methodology and relatively small sample size, the results of this study suggest a possible negative effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder. Taken together, these data provide the impetus for more rigorous evaluation of the mediational role of overweight/obesity (and other medical co-morbidity) on cognitive function in psychiatric populations.

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“…A number of research studies and meta-analyses suggest that signifi cant neurocognitive impairment is present during remission in many domains Bora et al 2009aBora et al , 2010aArts et al 2008 ;Jamrozinski 2010 ), in spite of some reservations (Gruber et al 2007 ;Kerr et al 2003 ). A meta-analysis reported that the illness phase had no effect on the short-term memory impairment (Goodwin and Jamison 2007 ), but some authors suggest that the impairment observed during the euthymic phase might be a consequence of antipsychotic medication alone (Jamrozinski et al 2009 ).…”

Section: The Effect Of Mood Symptomsmentioning

confidence: 96%

“…Overall, the severity of the disease is strongly related to neurocognitive function (Yates et al 2011 ). Onset in childhood or adolescence is related to more severe impairment (Jamrozinski 2010 ). In paediatric BD patients, a neurocognitive impairment is observed which is similar to adult patients (Dickstein et al 2004 ).…”

Section: The Effect Of Age and Age At Onset And Personal Psychiatric mentioning

confidence: 96%

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Fountoulakis

2014

Bipolar Disorder

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Do euthymic bipolar patients have normal cognitive functioning?

Cited by 16 publications

References 50 publications

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls

The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

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