The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder

Yim, Christina Y.; Soczynska, Joanna K.; Kennedy, Sidney H.; Woldeyohannes, Hanna O.; Brietzke, Elisa; McIntyre, Roger S.

doi:10.1016/j.eurpsy.2011.02.004

Cited by 96 publications

(64 citation statements)

References 42 publications

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“…Long-term use of high fat diet or high energy diet could induce obesity and affect serum lipid levels and oxidative stress, which in turn affect learning and memory functions [37,38,39]. The traditional Mediterranean-style diet has fewer meats and carbohydrates and more plant-based foods and monounsaturated fat than a typical American diet.…”

Section: Discussionmentioning

confidence: 99%

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Shi¹,

Chen²,

Zhao³

et al. 2014

JFNR

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Evidence suggests that dietary walnuts are able to induce improvements in memory and learning functions. In addition, polyphenols have been shown to modulate critical neuronal signalling pathways involved in processes of learning and memory. The aim of our present work was to study the effect of polyphenol extracts from walnut testa (42%) on learning and memory functions in hypercholesterolemia mice based on obesity, hypercholesterolemia and oxidative stress. At the beginning of the experiment, mice were divided into 3 groups, one of them served as normol control group (NCG), the second as hypercholesterolemia control group (HCG), the last as walnut polyphenol-treated group (WTG). After 8 weeks of treatment, we investigated the performance of C57BL/6J mice in Morris water maze test. The results showed that the escape latency was significant increase in HCG, when compared to NCG and WTG. In addition, the number of crossings was significant decrease in HCG, when compared to NCG and WTG (-47.35% and -43.35%, respectively, P < 0.01). The swimming distance was longer in HCG than NCG and WTG [F (2,96) = 44.45, P < 0.001]. However, there was no significant difference in swimming speed among NCG, HCG and WTG [F (2, 96) = 0.167, P > 0.05]. On the other hand, walnut polyphenol (WP) significantly decreased serum total triglycerides, cholesterol and malondialdehyde (MDA) level (-36.31%, -31.48% and -21.51%, respectively, P < 0.01) and increased superoxide dismutase (SOD) activity (+48.39%, P < 0.01). Administration of WP significantly decreased MDA level (-36.86%, P < 0.01) and increased SOD activity (+17.08%, P < 0.01) in brain tissues. In conclusion, walnut polyphenol was able to improve learning and memory functions.

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Section: Discussionmentioning

confidence: 99%

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Shi¹,

Chen²,

Zhao³

et al. 2014

JFNR

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“…Over-weight ⁄ obesity has also been shown to have a negative impact on long-term treatment response (283,289) and on cognitive function in euthymic patients with BD (292).…”

Section: Prevalence and Impactmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

et al. 2012

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Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O’Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher B, Ha K, Nolen WA, Berk M.  Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013.  Bipolar Disord 2012: 00: 000–000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd.The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009. This third update, in conjunction with the International Society for Bipolar Disorders, reviews new evidence and is designed to be used in conjunction with the previous publications.The recommendations for the management of acute mania remain largely unchanged. Lithium, valproate, and several atypical antipsychotic agents continue to be first‐line treatments for acute mania. Monotherapy with asenapine, paliperidone extended release (ER), and divalproex ER, as well as adjunctive asenapine, have been added as first‐line options.For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, as well as olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. Lurasidone monotherapy and the combination of lurasidone or lamotrigine plus lithium or divalproex have been added as a second‐line options. Ziprasidone alone or as adjunctive therapy, and adjunctive levetiracetam have been added as not‐recommended options for the treatment of bipolar depression. Lithium, lamotrigine, valproate, olanzapine, quetiapine, aripiprazole, risperidone long‐acting injection, and adjunctive ziprasidone continue to be first‐line options for maintenance treatment of bipolar disorder. Asenapine alone or as adjunctive therapy have been added as third‐line options.

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“…However, to date, only one study has shown that overweight patients with BD performed poorly on tasks assessing processing speed and attention when compared with normal weight patients with BD. 13 Participants in our study had an average duration of illness of 15 years and a mean of 7 episodes of both depression and mania, which indicates that obesity may negatively impact cognition in patients with established illness. However, the impact of overweight and obesity on cognitive functioning in patients early in the course of BD is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…To date, such predictors include medications, namely, mood stabilizers and atypical antipsychotics, 1,[6][7][8][9] substance abuse or dependence, 10 duration of illness and number of episodes, 1,6,11 childhood trauma, 12 and possibly obesity. 13 The deficits in the broad domains of attention, learning-memory, and executive function are also present even in patients with first-episode mania, where the variables associated with the progression of BD are fewer. [14][15][16] Overweight and (or) obesity have been reported to have a significant impact on the clinical course of BD, and potentially on cognitive functioning.…”

Section: Limitationsmentioning

confidence: 99%

Neurocognitive Functioning in Overweight and Obese Patients with Bipolar Disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

et al. 2014

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Objective: Obesity is frequent in people with bipolar I disorder (BD I) and has a major impact on the course of the illness. Although obesity negatively influences cognitive function in patients with BD, its impact in the early phase of the disorder is unknown. We investigated the impact of overweight and obesity on cognitive functioning in clinically stable patients with BD recently recovered from their first manic episode. Method: Sixty-five patients with BD (25 overweight or obese and 40 normal weight) recently remitted from a first episode of mania and 37 age- and sex-matched healthy control subjects (9 overweight or obese and 28 normal weight) were included in this analysis from the Systematic Treatment Optimization Program for Early Mania (commonly referred to as STOP-EM). All subjects had their cognitive function assessed using a standard neurocognitive battery. We compared cognitive function between normal weight patients, overweight-obese patients, and normal weight healthy control subjects. Results: There was a negative affect of BD diagnosis on the domains of attention, verbal memory, nonverbal memory, working memory, and executive function, but we were unable to find an additional effect of weight on cognitive functioning in patients. There was a trend for a negative correlation between body mass index and nonverbal memory in the patient group. Conclusions: These data suggest that overweight-obesity does not negatively influence cognitive function early in the course of BD. Given that there is evidence for a negative impact of obesity later in the course of illness, there may be an opportunity to address obesity early in the course of BD.

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The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder

Cited by 96 publications

References 42 publications

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

Neurocognitive Functioning in Overweight and Obese Patients with Bipolar Disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

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