Across the literature, the interest in the phenomenon of intolerance of uncertainty (IU) and worry has increased exponentially. However, limited empirical studies exist about the factors that affect IU and worry among older people. The purpose of the study was to examine the impact of spirituality, selfefficacy, and knowledge about aging on IU and worry. A total of 219 Filipino elderly were recruited from institutionalized and hospital care settings. A multiaspect questionnaire was utilized to measure spirituality, self-efficacy, knowledge, intolerance uncertainty, and worry. Exploratory factor analysis (EFA) was used to explore the dimensions of IU and worry. Moreover, structural equation modelling was used to test the hypothesized model. Results of EFA identified four factor dimensions of uncertainty, namely: perfection-driven uncertainty, apprehension-driven uncertainty, avoidance-driven uncertainty, negativism-driven uncertainty. Further, three factor dimensions of worry were also distinguished: constant worriers, obsessive-compulsive worriers, and happy-go-lucky worriers. Moreover, results of structural equation modeling (SEM) showed interaction among the variables presented. Additionally, spirituality showed a positive effect on self-efficacy. However, self-efficacy does not have an effect on IU and worry. Nevertheless, an emerging path between knowledge and IU supported the claim of Nuevo, Wetherell, Montorio, Ruiz, and Cabrera (2009). The study was able to determine the positive effect of spirituality to self-efficacy and its existing correlation with knowledge about aging in relation to elderly's IU and worry. The emerging model can serve as a reference for nurses to address the sociopsychological needs of the geriatric clients employing spirituality and psychiatric nursing.Intolerance of uncertainty is defined as a cognitive bias that affects how a person perceives, interprets, and responds to uncertain situations on a cognitive, emotional, and behavioral level