Do lipids shape the eukaryotic cell cycle?

Abstract

Successful passage through the cell cycle presents a number of structural challenges to the cell. Inceptive studies carried out in the last five years have produced clear evidence of modulations in the lipid profile (sometimes referred to as the lipidome) of eukaryotes as a function of the cell cycle. This mounting body of evidence indicates that lipids play key roles in the structural transformations seen across the cycle. The accumulation of this evidence coincides with a revolution in our understanding of how lipid composition regulates a plethora of biological processes ranging from protein activity through to cellular signalling and membrane compartmentalisation. In this review, we discuss evidence from biological, chemical and physical studies of the lipid fraction across the cell cycle that demonstrate that lipids are well-developed cellular components at the heart of the biological machinery responsible for managing progress through the cell cycle. Furthermore, we discuss the mechanisms by which this careful control is exercised.

Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism

“…The lipid content must accommodate dynamic changes in membrane curvature. For example, during cytokinesis, it is thought that lipids that confer negative curvature must be deposited on the outer leaflet of the bilayer ( Furse and Shearman, 2018 ). In yeast and human cells, inhibition of de novo fatty acid biosynthesis arrests cells in mitosis ( Hasslacher et al , 1993 ; Schneiter et al , 1996 ; Al-Feel et al , 2003 ; Scaglia et al , 2014 ).…”

Lipid Biosynthesis as an Antifungal Target

“…The composition and localization of lipids are remodulated during the cell cycle. Therefore, the lipid composition of the cell membrane structure itself is very important to the cell [ 12 , 13 ].…”

SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy

“…Lipids form the basic structures for the plasma membrane and for membranes of all cellular organelles. In addition, lipids serve as energy resources and function as important signaling molecules, regulating various cellular functions, such as migration, cell cycle, cell division and differentiation [2–7]. Markedly increased lipid requirement is associated with the rapid growth and proliferation of tumor cells [8–12].…”