Do long‐chain omega‐3 fatty acids protect from atopic dermatitis?

Reese, Imke; Werfel, Thomas

doi:10.1111/ddg.12780

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…Supplementation with n-3 PUFAs during pregnancy leads to a decrease in incidence and intensity of AD in children [259,260]. In addition, infants with higher plasma levels of n-3 PUFAs have significantly reduced the prevalence of eczema [261]. In contrast, a diet low in n-3 PUFA intake is associated with an increased risk of AD development [262][263][264][265].…”

Section: Atopic Dermatitismentioning

confidence: 99%

“…↓ Frequency of eczema [261] Adulthood ↓ Severity and symptoms [271,272,275] ↑ SCORing Atopic Dermatitis (SCORAD) after 4, 8 and 16 weeks of treatment [273] Food Allergy Pregnancy and lactation ↓ Allergic sensitization to food proteins (antigen-dependent effect) [196,260,[277][278][279][280]289] Infancy and childhood ↓ Odds ratio for food allergy and ↓ risk for sensitization (antigen-dependent effect) [259,277,281,282,287] Autoimmune Diseases Effects of n-3 PUFAs Ref.…”

Section: Infancy and Childhoodmentioning

confidence: 99%

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The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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Section: Atopic Dermatitismentioning

confidence: 99%

Section: Infancy and Childhoodmentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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“…Thus, this may predispose individuals to allergic disorders (via effects on T and B cells) and also enhances allergic inflammatory mechanisms. Therefore, the effects of excess omega-6 fatty acids on the immune system could be detrimental [51].…”

Section: Effect Of Molecule Break Up/degradation On Immunitymentioning

confidence: 99%

“…Findings of two large studies (Sydney Diet Heart Study (1966)(1967)(1968)(1969)(1970)(1971)(1972)(1973) and Minnesota Coronary Experiment (1968)(1969)(1970)(1971)(1972)(1973) indicated that replacement of naturally evolved dietary saturated fats with oils rich in linoleic acid (omega-6 fatty acid) increased the chance of mortality from coronary heart disease [53]. This may well have resulted from an increase in linoleic acid in cells of the body, which leads to the afore-mentioned increasing production of linoleic acid oxidized derivatives and pro-inflammatory prostaglandins and leukotrienes [32] [51]. The increase in pro-inflammatory mediators promotes chronic inflammation of the body, particularly endothelial cells of the arteries leads to coronary heart disease and stroke.…”

Section: Rise Of Non-communicable Diseasesmentioning

confidence: 99%

Dietary Fats and Oils: Some Evolutionary and Historical Perspectives Concerning Edible Lipids for Human Consumption

Roccisano¹,

Kumaratilake²,

Saniotis³

et al. 2016

FNS

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Consumption of fats and oils in the ancient world was examined as a window to human nutritional needs and compared with lipid usage in the modern world, post-1900. In earlier periods, the natural and only source of edible fats and oils came from both animals and plants. These fats and oils played a vital role in the evolution of the human body structure, supporting many biochemical functions. Artifacts from prehistoric periods and the ancient world had indicated that humans were evolutionarily adapted to consume saturated lipids. They also consumed unsaturated fats and oils extracted from animals and plants, now identified as omega-3 to omega-6 in the fatty acid ratio of 1:1, commonly derived from naturally consumed unprocessed products and food sources. These fats and oils assisted in providing the ingredients for the building up of cells and maintaining their structural integrity in tissues, including the brain and other important internal organs, as well as providing energy for many biochemical processes in the body. The double bonds distributed throughout fatty acid carbon chains are a characteristic of unsaturated vegetable oils. They are more structurally diverse in polyunsaturated fats and oils with the greater preponderance for carbon-to-carbon double bonds distributed in the carbon chains. These double bonds are susceptible to generating free radicals. This article considers potential problems that proponents of the prevailing diet-heart cholesterol paradigm of the past 60 years may have neglected. It also presents the possible consequences of abandoning the evolutionarily inherited foods containing extracted natural saturated and monounsaturated fats and oils. Furthermore, the article addresses the contribution of docosahexaenoic and eicosapentaenoic acids to immunity and the possible * Corresponding author. D. Roccisano et al. 690 connection of excess consumption of omega-6 fatty acid to the marked rise in obesity and other non-communicable diseases in modern civilization.

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“…Supplementation of long-chain omega-3 fatty acids, the essential human nutrition, was reported to be a promising way in the prevention of AD since the antiinflammatory effect. However, this concept still cannot be confirmed and needs more randomized controlled intervention studies [48,49]. MicroRNAs (miRNA) are a class of non-coding RNA molecules that modulate gene expression post-transcriptionally.…”

Section: Decrease Skin Inflammationmentioning

confidence: 99%

Potential Treatments for Atopic Dermatitis

Kao¹,

Shieh²,

Lee³

et al. 2016

J immuno Biol

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Atopic Dermatitis (AD) is the most common pruritic inflammatory skin disease which causes economic and social burden. AD is not curable and therapeutic options are limited. Currently, the therapeutic approaches to AD include topical treatment, phototherapy, and systemic treatment. Although traditional therapeutic strategies are efficacious in ameliorating the symptoms of AD in most patients, sometimes it is a tough challenge for physicians as AD is catastrophic and difficult to treat. Several potential treatments for AD are being studied owing to a clearer understanding of its pathogenesis. Additionally, animal models of AD allow comprehensive and thorough investigation of pathogenesis and provide more options of therapeutic interventions. The purpose of non-classical treatment strategies for AD is to decrease skin inflammation, re-direct the imbalanced immune polarization, and induce immune tolerance to allergens. Generally, the intervention for mouse model of AD can be classified into 1) monoclonal antibodies, 2) anti-oxidants, 3) allergen-specific immunotherapy, 4) herbal medicine, 5) treatment with materials extracted from food or micronutrients, 6) microbiota/probiotics, 7) bio-composites films, and 8) others. Since half of the patients with AD lack specific immunoglobulin E against allergens, the pathogenesis of different phenotypes still needs to be clarified. Through novel therapies such as cytokine-targeting therapy, miRNA or suppression of thymic stromal lymphopoietin, patients with AD could have better quality of life with less morbidity.

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Do long‐chain omega‐3 fatty acids protect from atopic dermatitis?

Cited by 7 publications

References 41 publications

The Influence of Dietary Fatty Acids on Immune Responses

The Influence of Dietary Fatty Acids on Immune Responses

Dietary Fats and Oils: Some Evolutionary and Historical Perspectives Concerning Edible Lipids for Human Consumption

Potential Treatments for Atopic Dermatitis

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