Do mast cells play a pathogenetic role in neurofibromatosis type 1 and ulcerative colitis?

Baratelli, Felicita; Le, Michael; Gershman, George; French, Samuel W.

doi:10.1016/j.yexmp.2014.02.006

Cited by 18 publications

(20 citation statements)

References 17 publications

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“…MC interaction with nerve cells is mediated by substance P, a neuropeptide known to enhance mucosal MC activity also in chronic inflammation of IBD. This suggests that interaction between neuronal fibers and MCs may lead to amplification and perpetuation of inflammatory damage in IBD [61].…”

Section: Poormentioning

confidence: 98%

The Role of Mast Cells in Molding the Tumor Microenvironment

Rigoni

Colombo

Pucillo

2014

Cancer Microenvironment

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Mast cells (MCs) are granulocytic immune cells that reside in tissues exposed to the external environment. MCs are best known for their activity in allergic reactions, but they have been involved in different physiological and pathological conditions. In particular, MC infiltration has been shown in several types of human tumors and in animal cancer models. Nevertheless, the role of MCs in the tumor microenvironment is still debated because they have been associated either to good or poor prognosis depending on tumor type and tissue localization. This dichotomous role relies on MC capacity to secrete a broad spectrum of molecules with modulatory functions, which may condition the final tumor outcome also promoting angiogenesis and tissue remodeling. In this review, we analyze the multifaceted role of mast cell in tumor progression and inhibition considering their ability to interact with: i) immune cells, ii) tumor cells and iii) the extracellular matrix. Eventually, the current MC targeting strategies to treat cancer patients are discussed. Deciphering the actual role of MCs in tumor onset and progression is crucial to identify MC-targeted treatments aimed at killing cancer cells or at making the tumor vulnerable to selected anti-cancer drugs.

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Section: Poormentioning

confidence: 98%

The Role of Mast Cells in Molding the Tumor Microenvironment

Rigoni

Colombo

Pucillo

2014

Cancer Microenvironment

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“…In general, neurofibromas are usually treated by surgical excision and recurrence is not common; however, all patients presenting neurofibroma should be clinically evaluated for the possibility of neurofibromatosis . Malignant transformation of solitary neurofibromas may occur, although the risk appears to be very low, especially compared to that in patients presenting neurofibromatosis, of 5% to 15% …”

Section: Discussionmentioning

confidence: 99%

Neurofibromas of the oral and maxillofacial complex: A 48‐year retrospective study

et al. 2019

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Neurofibromas are benign neoplasms of the peripheral nerve sheath, characterized by the proliferation of Schwann cells, perineural cells and endoneural fibroblasts.Their occurrence in the oral and maxillofacial complex is uncommon. This study aimed to evaluate the clinical and histopathological characteristics of neurofibromas of the oral and maxillofacial complex excised at our institution over a 48-year period.Using light microscopy, two previously trained oral pathologists re-evaluated all hematoxylin and eosin slides. From a total of 15,375 cases diagnosed at a referred Oral Pathology Service, 24 cases were diagnosed as neurofibromas. Eighteen neurofibroma patients were female, with a mean age of 39.1 years. Three patients presenting neurofibromas exhibited neurofibromatosis type I. Clinically, most of the lesions presented as asymptomatic nodules, and the most frequent sites were the tongue (n = 6; 25.0%), gingiva (n = 6; 25.0%) and intraosseous maxillary bone region (n = 3; 12.5%). Histopathologically, the lesions were predominantly well delimited, exhibiting interlocking bundles of spindle-shaped cells that usually displayed wavy nuclei, associated with delicate collagen fibers. Thus, knowledge of their clinical and histopathological features by dentists and oral pathologists is essential for the correct diagnosis of these lesions. K E Y W O R D Sdiagnosis, mouth neoplasms, nerve sheath neoplasms, pathology

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“…Since the pathogenesis of IBD is also associated with genetic make-up, these two entities may be associated with a genetic factor. However, any genetic association between IBD and NF1 remains to be elucidated, and only four reports of UC with NF1 and one report of Crohn's disease with NF1 are available [2][3][4][5]. It will be necessary to accumulate more cases of IBD with NF1 to clarify this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Ulcerative Colitis with Neurofibromatosis Type 1

Fukunaga

Takedatsu²,

Mitsuyama

et al. 2017

Kurume Med. J.

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Concomitant association of histologically proven inflammatory bowel disease (IBD) and neurofibromatosis type 1 (NF1) is a rare finding documented in only 5 adult clinical cases. A 34-year-old woman with known neurofibromatosis was admitted to our department with a 6-month history of intractable bloody diarrhea and abdominal pain. After a thorough clinical examination and paraclinical assessments, including colonoscopy and biopsy, ulcerative colitis (UC) was confirmed as the cause of gastrointestinal bleeding. NF1 is considered an autosomal dominant condition caused by mutations in the NF1 gene, which is located on chromosome 17q11.2 [1]. A wide variety of NF1 mutations have been found in patients with NF1, but no frequently recurring mutation has been identified. Since the pathogenesis of IBD is also associated with genetic make-up, these two entities may be associated with a genetic factor.

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Do mast cells play a pathogenetic role in neurofibromatosis type 1 and ulcerative colitis?

Cited by 18 publications

References 17 publications

The Role of Mast Cells in Molding the Tumor Microenvironment

The Role of Mast Cells in Molding the Tumor Microenvironment

Neurofibromas of the oral and maxillofacial complex: A 48‐year retrospective study

A Rare Case of Ulcerative Colitis with Neurofibromatosis Type 1

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