Do Nasal Ciliary Changes Reflect Bronchial Changes?: An Ultrastructural Study

Verra, F.; Fleury‐Feith, Jocelyne; Boucherat, M.; Pinchon, M. C.; Bignon, J; Escudier, Estelle

doi:10.1164/ajrccm/147.4.908

Cited by 46 publications

(31 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reported results include the type of defect (dynein defects are most specific), the percentage of cilia having the defect, the distribution of the defect (bronchial versus nasal if both areas are assessed), and the number of cilia present. 107,108 Because acquired ciliary defects can sometimes mimic primary ciliary dyskinesia in the presence of chronic inflammation, tracheal biopsy is frequently required for confirmation of this diagnosis. Immunodeficiency tests.…”

Section: Summary Statementsmentioning

confidence: 99%

The diagnosis and management of sinusitis: A practice parameter update

Slavin

Spector

Bernstein

et al. 2005

Journal of Allergy and Clinical Immunology

333

369

View full text Add to dashboard Cite

Section: Summary Statementsmentioning

confidence: 99%

The diagnosis and management of sinusitis: A practice parameter update

Slavin

Spector

Bernstein

et al. 2005

Journal of Allergy and Clinical Immunology

333

369

View full text Add to dashboard Cite

“…Airway biopsies were immersed in 2.5% glutaraldehyde and processed as usual for ultrastructural analysis [8]. Ultrathin sections were examined at a final magnification of 660,000 without knowledge of the clinical data.…”

Section: Ciliary Ultrastructurementioning

confidence: 99%

A 20-year experience of electron microscopy in the diagnosis of primary ciliary dyskinesia

Papon¹,

Coste²,

et al. 2009

View full text Add to dashboard Cite

Transmission electron microscopy (TEM) analysis of ciliary ultrastructure is classically used for the diagnosis of primary ciliary dyskinesia (PCD). We report our extensive experience of TEM analysis in a large series of patients in order to evaluate its feasibility and results.TEM analysis performed in 1,149 patients with suspected PCD was retrospectively reviewed. Biopsies (1,450) were obtained from nasal (44%) or bronchial (56%) mucosa in children (66.5%) and adults (33.5%).TEM analysis was feasible in 71.4% of patients and showed a main defect suggestive of PCD in 29.9%. TEM was more feasible in adults than in children, regardless of the biopsy site. Main defects suggestive of PCD were found in 76.9% of patients with sinopulmonary symptoms and in only 0.4% of patients with isolated upper and 0.4% with isolated lower respiratory tract infections. The defect pattern was similar in children and adults, involving dynein arms (81.2%) or central complex (CC) (18.8%). Situs inversus was never observed in PCD patients with CC defect. Kartagener syndrome with normal ciliary ultrastructure was not an exceptional condition (10.2% of PCD).In conclusion, TEM analysis is feasible in most patients and is particularly useful for PCD diagnosis in cases of sinopulmonary syndrome of unknown origin.

show abstract

“…There do not appear to be any significant ultrastructural differences between bronchial and nasal cilia [33], or age-related changes [34]. Ciliary disorientation was recently described as a possible variant of PCD [35,36].…”

Section: -Diagnostic Algorithm For Primary Ciliary Dyskinesia (Pcd)mentioning

confidence: 99%

Primary ciliary dyskinesia: diagnosis and standards of care

Bush¹,

Cole²,

Hariri³

et al. 1998

Eur Respir J

347

285

View full text Add to dashboard Cite

Primary ciliary dyskinesia (PCD) is characterized by disease of the upper and lower respiratory tract, in association with visceral mirror image arrangement in 50% of cases, due to abnormal structure and/or function of cilia. The purpose of this paper is to review the clinical features, diagnosis and management of PCD. Presentations include neonatal respiratory distress, recurrent lower respiratory tract infection, chronic rhinosinusitis and male infertility. PCD enters the differential diagnosis of bronchiectasis, atypical asthma, and unusually severe upper airway disease. Diagnosis is by a cascade of investigations, starting with the saccharin test in patients older than 10 yrs; ciliary beat frequency and pattern on light microscopy; and electron microscopy to assess ciliary morphology and orientation. It is important not to confuse primary and secondary ciliary abnormalities. Nasal nitric oxide is low in PCD, and this measurement shows promise as a screening test for PCD. Diagnosis is important, in order to prevent the development of bronchiectasis and to avoid any unnecessary otorhinolaryngological procedures. Regular follow-up is essential, and management should be multidisciplinary, with input from centres with a special interest in PCD, having access to paediatric and adult chest physicians, otolaryngologists and audiological physicians, physiotherapists, counselling services and fertility clinics. The prognosis is good, but morbidity can be considerable if PCD is incorrectly managed.

show abstract

Do Nasal Ciliary Changes Reflect Bronchial Changes?: An Ultrastructural Study

Cited by 46 publications

References 11 publications

The diagnosis and management of sinusitis: A practice parameter update

The diagnosis and management of sinusitis: A practice parameter update

A 20-year experience of electron microscopy in the diagnosis of primary ciliary dyskinesia

Primary ciliary dyskinesia: diagnosis and standards of care

Contact Info

Product

Resources

About