Do patients with high-functioning autism have similar social cognitive deficits as patients with a chronic cause of schizophrenia?

Veddum, Lotte; Pedersen, Heine Lund; Landert, Anna-Sofie Lose; Bliksted, Vibeke

doi:10.1080/08039488.2018.1554697

Cited by 16 publications

(21 citation statements)

References 43 publications

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“…Inconsistencies in prior findings have been posited to be due to the utilization of different social cognition tasks across studies (55,58), which also likely measure other aspects of social cognition compared to the task used in our current study. Only two studies have examined social cognition performance in ASD and psychosis using the TASIT, with both finding no significant differences between these clinical groups on TASIT performance consistent with our current findings (54,56).…”

Section: Discussionsupporting

confidence: 88%

“…While some studies have similarly found comparable social cognitive abilities in individuals with psychosis and ASD (54-56), others have found a trend towards poorer performance on emotion recognition tasks in individuals with ASD compared to psychosis (55,57). One study found that while there were no group differences in overall social cognition performance between ASD and psychosis, individuals with ASD showed significant deficits only on the social perception task (TASIT) compared to healthy controls, while individuals with psychosis showed deficits on both the social perception task (TASIT) and the ToM task (anthropomorphic animations) compared to healthy controls (54). A meta-analytic review of social cognition in ASD and psychosis concluded that both groups perform poorly on ToM tasks using anthropomorphic animations, but with subtle differences: individuals with ASD performed more poorly than those with psychosis on appropriate descriptions of these animations, whereas individuals with psychosis perform more poorly than those with ASD on ascribing intentions to such animations (58).…”

Section: Discussionmentioning

confidence: 99%

“…Our results are consistent with previous findings (59-61), wherein ASD individuals consistently performed better on untimed motor-free nonverbal tasks (relative to tasks that were timed and/or had a motor component). In comparing patients with (idiopathic) psychosis and ASD to healthy controls, Veddum et al (2019) recently found that deficits across multiple neurocognitive domains were more evident in those with psychosis, despite similar social impairments between the two groups. Notably though, while we found significant positive correlations between verbal skills and social cognition performance in ASD youth, this relationship was not observed for nonverbal skills.…”

Section: Discussionmentioning

confidence: 99%

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Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Jalal

Nair

Lin

et al. 2020

Preprint

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KEYWORDS 2 22q11.2 deletion, social cognition, neurocognition, psychosis, autism spectrum disorder 3 Abstract Background 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities.Finally, we examined the relationship between social cognitive abilities and real-world social behavior. MethodsWe examined social cognition and intellectual functioning in 306 participants (mean age = 16.63+/-4.59; % female = 44.8%): sixty-eight with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 117 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS).Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. ResultsThe 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. ConclusionsOur findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. the most common recurrent contiguous gene deletion syndrome, estimated to occur in about 1 in 4000 live births (2). It typically results from a de novo deletion, although 10% of cases are familial (3,4). 22q11DS is associated with a range of developmental anomalies (5). The most frequently associated medical comorbidities include congenital heart defects, facial dysmorphology such as palatal defects, immunodeficiency, velopharyngeal insufficiency, and hypocalcemia (2, 6).Individuals with 22q11DS often present with developmental delays, as well as broad cognitive impairment (6). In most individuals with 22q11DS, Full Scale IQ falls within the borderline to low average range (M = 72.41, SD = ± 13.72; 7). A range of associated cognitive deficits have also been noted in individuals with 22q11...

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Jalal

Nair

Lin

et al. 2020

Preprint

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“…Measures of ever yday functioning were also rare (k = 5). 29,60,[62][63][64] Ten articles 28,30,50,53-57,60,62 reported neuroimaging data in conjunction with performance-based social cognition.…”

Section: Social Cognitive and Additional Measuresmentioning

confidence: 99%

Social Cognitive Performance in Schizophrenia Spectrum Disorders Compared With Autism Spectrum Disorder

et al. 2021

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IMPORTANCE Schizophrenia spectrum disorders (SSDs) and autism spectrum disorder (ASD) both feature social cognitive deficits; however, these disorders historically have been examined separately using a range of tests and subdomain focus and at different time points in the life span. Moving beyond diagnostic categories and characterizing social cognitive deficits can enhance understanding of shared pathways across these disorders.OBJECTIVE To investigate how deficits in social cognitive domains diverge or overlap between SSDs and ASD based on the extant literature.

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“…There are few empirical data directly comparing both populations to test this hypothesis. This phenomenon is partly due to differences inherent to both disorders that make comparisons between both populations particularly challenging, e.g., differences in prevalence with respect to sex (female-male ratio: 0.92:1 for SSD and 1:4 for ASD, (CDC 2007;Aleman et al 2003;Lugnegard et al 2013), the mean intelligence quotient (IQ) score in representative samples of each disorder (Goldstein et al 2002;Fernandes et al 2018;Veddum et al 2019) and typically different exposure to interventions (such as pharmacotherapy or psychological interventions). In addition, most instruments used to assess social cognition have been developed, and their psychometric properties have been tested in one population or the other.…”

Section: Introductionmentioning

confidence: 99%

Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different?

Boada

Lahera

Pina‐Camacho

et al. 2020

J Autism Dev Disord

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Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Only performance on the Movie for the Assessment of Social Cognition (MASC) test was independent of age and intelligence. Proportionately, individuals in the control group made significantly more overmentalization errors than both patients group did and made fewer undermentalization errors than patients with SSD did. AUC analyses showed that the MASC was the instrument that best discriminated between the clinical and control groups. Multivariate analysis showed negative symptom severity as a potential mediator of the association between social cognition deficit and poor global functioning.

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Do patients with high-functioning autism have similar social cognitive deficits as patients with a chronic cause of schizophrenia?

Abstract: Do patients with high-functioning autism have similar social cognitive deficits as patients with a chronic cause of schizophrenia?

Cited by 16 publications

References 43 publications

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Social Cognitive Performance in Schizophrenia Spectrum Disorders Compared With Autism Spectrum Disorder

Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different?

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