Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Abstract

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Clinical Features and Outcomes of Patients With Human Immunodeficiency Virus With COVID-19

“…5 The difference in age between HIV-positive and HIV-negative patients with COVID-19 may possibly be explained by the general belief that HIV infection can add nearly 10 years to the chronological age. 11,12 This is indirectly supported by the fact that, although they are about 50 years old, the large majority of our patients have at least one co-morbidity, a picture that is more frequently observed in patients aged >60 years in the general population.…”

“…A c c e p t e d M a n u s c r i p t 10 A c c e p t e d M a n u s c r i p t 11 A c c e p t e d M a n u s c r i p t 13…”

Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults

“…It is also a protein that fluctuates with various biological states and is not specific to HIV or age. In addition, we know that chronic inflammation and immune activation typically observed in older adults can be observed much earlier in PWH, and this concept of "inflammaging" is critical to address as it significantly affect quality of life (De Francesco et al, 2019;Nasi et al, 2017). Therefore, inclusion of additional chronicillness, inflammatory, and age-related biomarkers, as well as HIV disease characteristics as indicators of physical health may strengthen findings and should be considered for future directions.…”

Acute Myeloid Leukemia in Patients Living with HIV Infection: Several Questions, Fewer Answers

“…For instance, therapy-related myeloid neoplasms (t-MN) account for nearly 10%-20% of all MDS or AML cases in the general population, and they could potentially become more frequent in HIV-positive patients, who can actually achieve long-term disease-free survival after having received effective anti-tumor treatment in combination with ART for primary malignancy [22,48]. In addition to these leukemogenic mechanisms, it has long been hypothesized that patients with HIV infection exhibit a global accelerated aging, therefore resulting in development of age-related comorbidities earlier than expected for their age [23,49]. Relevant to this, despite a younger age at presentation, a higher proportion of clonal-hematopoiesis related mutations, mainly ASXL1 and DNMT3A gene mutations, and higher risk cytogenetics have recently been found in HIV-positive MDS individuals, compared with HIV-negative counterparts [23].…”