Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?

Martyniak, Kari; Wei, Fei; Ballesteros, Amelia; Meckmongkol, Teerin; Calder, Ashley; Gilbertson, Timothy A.; Orlovskaya, Nina; Coathup, Melanie

doi:10.1016/j.bone.2020.115736

Cited by 32 publications

(22 citation statements)

References 202 publications

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“…Soybean food is the main source of essential omega-3 fatty acids, which have been shown to enhance bone health by diminishing osteoporosis [36]. 1 Adjusted for age, sex/menopausal status, race/ethnicity; 2 further adjusted for education, marital status, PIR, BMI, smoking status, status of hypertension, status of diabetes, taken prednisone or cortisone, history of fracture A diet rich in saturated fatty acids can seriously damage bone regeneration and repair, thereby increasing the risk of osteoporosis [37]. This is different from our conclusion.…”

Section: Discussionmentioning

confidence: 99%

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

Fan

Zhang

2021

Osteoporos Int

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We used NHANES data to explore the association between dietary quality estimated by the HEI-2015 and osteoporosis in middle-aged and elderly US adults. We found that higher dietary quality is significantly associated with a reduced risk of osteoporosis among middle-aged and elderly Americans. Introduction Through this research, we assess whether increasing the overall dietary quality reduces the risk of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

Fan

Zhang

2021

Osteoporos Int

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“…Osteoporosis (OP) is a chronic, systemic endocrine and metabolic disorder, whether it is primary osteoporosis due to aging or sex hormone deficiency or secondary osteoporosis due to hyperthyroidism, diabetes, obesity, Cushing's syndrome, anorexia, rheumatoid arthritis and drug effects. The underlying mechanism is the imbalance of bone remodeling in which the loss of bone mass occurs faster than bone production (5)(6)(7)(8)(9)(10)(11). Osteoporosis and related fractures have become a major public health problem and have substantially increased health care costs.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the pathogenesis and treatment of various diseases in the body based on energy metabolism, such as tumors, cardiovascular diseases and nervous system diseases (12)(13)(14)(15), has been a hot topic. Osteoporosis is also a disorder of systemic energy metabolism and glucose and lipid metabolism characterized by an abnormal fatty acid distribution and amino acid content, all of which are closely related to the occurrence and development of osteoporosis (8,(16)(17)(18). Focusing on the bone micro environment, the specific energy metabolism disorder of osteoblasts and osteoclasts is the key to pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis

Lin

Zhu

2021

Front. Endocrinol.

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In recent decades, the mechanism underlying bone metabolic disorders based on energy metabolism has been heavily researched. Bone resorption by osteoclasts plays an important role in the occurrence and development of osteoporosis. However, the mechanism underlying the osteoclast energy metabolism disorder that interferes with bone homeostasis has not been determined. Bone resorption by osteoclasts is a process that consumes large amounts of adenosine triphosphate (ATP) produced by glycolysis and oxidative phosphorylation. In addition to glucose, fatty acids and amino acids can also be used as substrates to produce energy through oxidative phosphorylation. In this review, we summarize and analyze the energy-based phenotypic changes, epigenetic regulation, and coupling with systemic energy metabolism of osteoclasts during the development and progression of osteoporosis. At the same time, we propose a hypothesis, the compensatory recovery mechanism (involving the balance between osteoclast survival and functional activation), which may provide a new approach for the treatment of osteoporosis.

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“…There are other potential mechanisms associated with inflammation that can be boosted by the inflammatory effect of a diet that can be related to bone metabolism. Pro-inflammatory diets might promote glucose and insulin secretion homeostasis disruption, and assist in the chronic activation of pro-inflammatory pathways that benefit the osteoclastogenesis, bone resorption processes, and the disruption of the normal function of osteoblasts [49][50][51]. In the same way, oxidative stress, as an exacerbating circumstance of the inflammatory process, may also have a key role in bone deterioration [52].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

et al. 2021

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Purpose Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55–75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) − 0.02 (− 0.04, − 0.01)], trochanter areas [β (95% CI) − 0.03 (− 0.05, − 0.01)] and lumbar spine area [β (95% CI) − 0.03 (− 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome.

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Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?

Cited by 32 publications

References 202 publications

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis

Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

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