Do preoperative chlorhexidine baths reduce the risk of infection after vascular reconstruction?

Earnshaw, J. J.; Berridge, David; Slack, R. C. B.; Makin, G. S.; Hopkinson, Brian R.

doi:10.1016/s0950-821x(89)80068-4

Cited by 48 publications

(59 citation statements)

References 13 publications

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“…To prevent this, the elimination of bacterial contamination of the operative site at the time of surgery remains a key factor [4,5]. A wide variety of active chemical agents are found in these products, many of which have been used for hundreds of years, including alcohols, phenols, iodine, and chlorine [6].…”

Section: Introductionmentioning

confidence: 99%

Ototoxicity of Different Concentrations Povidone-Iodine Solution Applied to the Middle Ear Cavity of Rats

Özkırış

Kapusuz

Saydam

2013

Indian J Otolaryngol Head Neck Surg

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To investigate the ototoxic effects of different concentrations of povidone-iodine solutions applied to the middle ear cavity of rats using distortion product otoacoustic emissions. 24 healthy 3-3.5-month-old adult female Sprague-Dawley rats were randomly divided into three groups. The group A (n = 8 ears) received 5 % povidone-iodine solution to the right ear, the group B (n = 8 ears) received 7.5 % povidone-iodine solution to the right ear and the group C (n = 8 ears) received 10 % povidone-iodine solution to the right ear. All animals received saline solution to the left ear as a control (n = 24 ears). The animals were tested before, 1 and 10 days after solutions administration to the middle ear. The resulting distortion product otoacoustic emissions were evaluated at 1.5, 2, 3, 4, 5, 6, 7, 8, 10 and 12 kHz. Statistically significant reductions in DP-gram amplitudes were noted at high frequencies (7,8,10, 12 kHz) in the group A at day 1 but this effect return at day 10. In group B and group C statistically significant differences were recorded for low and high frequencies (1.5,2,7,8,10, 12 kHz) according to the control group at day 1 and 10. 7.5 and 10 % povidoneiodine showed a significant ototoxic effect on day 1 and 10. But this toxic effect could not be elicited in 5 % povidoneiodine group on day 10. The present study revealed that commercially available high concentration povidoneiodine solution may cause significant ototoxic effects when applied topically through a perforated ear drum in rats. Based on results of this experiment, high concentration povidone-iodine solutions should not be used for preoperative surgical site cleansing for otologic surgery.

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Section: Introductionmentioning

confidence: 99%

Ototoxicity of Different Concentrations Povidone-Iodine Solution Applied to the Middle Ear Cavity of Rats

Özkırış

Kapusuz

Saydam

2013

Indian J Otolaryngol Head Neck Surg

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“…1,7,8 Preoperative showering with antiseptic agents is practiced routinely to reduce skin colonization at the site of the surgical incision. 5,6,14 The expected outcome from this added effort is a reduction in the transient and normal flora of the skin surrounding the operative site, which contributes to surgical infections.…”

Section: Discussionmentioning

confidence: 99%

“…6,14 -16,20 However, other trials have reported that antiseptic preoperative showers failed to influence the incidence of postoperative infection. 5,7,17 Given that the expected infection rates following clean elective procedures are 2 percent or less, possibly because of perioperative antibiotic prophylaxis, advantages attributable exclusively to preoperative showering are difficult to determine. 14,[21][22][23] The most frequently isolated pathogens from surgical site infections are S. aureus and coagulasenegative staphylococci.…”

Section: Discussionmentioning

confidence: 99%

“…6 Thus, a key factor in preventing infection is the elimination of bacterial contamination of the operative site at the time of surgery. 1,[5][6][7][8] Reducing skin flora preoperatively with appropriate antiseptic agents might be beneficial. 7 Povidone-iodine was introduced into AngloAmerican countries toward the end of the 1960s.…”

mentioning

confidence: 99%

“…1,[5][6][7][8] Reducing skin flora preoperatively with appropriate antiseptic agents might be beneficial. 7 Povidone-iodine was introduced into AngloAmerican countries toward the end of the 1960s. 9 This substance has a broad antimicrobial spectrum, and it is widely used in the preparation of the surgical site.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Influence of Povidone-Iodine Preoperative Showers on Skin Colonization in Elective Plastic Surgery Procedures

Veiga

Damasceno

Filho

et al. 2008

Plastic and Reconstructive Surgery

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Evidence for a Standardized Preadmission Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of Chlorhexidine Gluconate, 4%, in Surgical Patients

et al. 2015

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A standardized preadmission shower regimen that includes 118 mL of aqueous chlorhexidine gluconate, 4%, per shower; a minimum of 2 sequential showers; and a 1-minute pause before rinsing results in maximal skin surface (16.5 µg/cm2) concentrations of chlorhexidine gluconate that are sufficient to inhibit or kill gram-positive or gram-negative surgical wound pathogens. This showering regimen corrects deficiencies present in current nonstandardized preadmission shower protocols for patients undergoing elective surgery.

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Do preoperative chlorhexidine baths reduce the risk of infection after vascular reconstruction?

Cited by 48 publications

References 13 publications

Ototoxicity of Different Concentrations Povidone-Iodine Solution Applied to the Middle Ear Cavity of Rats

Ototoxicity of Different Concentrations Povidone-Iodine Solution Applied to the Middle Ear Cavity of Rats

Influence of Povidone-Iodine Preoperative Showers on Skin Colonization in Elective Plastic Surgery Procedures

Evidence for a Standardized Preadmission Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of Chlorhexidine Gluconate, 4%, in Surgical Patients

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