Do saw palmetto extracts block human?1-adrenoceptor subtypes in vivo?

Goepel, Μ.; Dinh, Lin; Mitchell, Anna; Schäfers, Rainhild; Rübben, H.; Michel, Martin C.

doi:10.1002/1097-0045(20010215)46:3<226::aid-pros1027>3.0.co;2-r

Cited by 20 publications

(11 citation statements)

References 24 publications

(28 reference statements)

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“…Obviously, because of the vegetal nature of the extract, it is necessary to have substances that have fixed and constant concentration (18). From the patient's point of view, Serenoa repens is a noninvasive approach to AGA, with no side effects.…”

Section: Discussionmentioning

confidence: 99%

Comparitive Effectiveness and Finasteride Vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

Rossi

Mari

Scarnò³

et al. 2012

Int J Immunopathol Pharmacol

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The objective of this open label study is to determine the effectiveness of Serenoa repens in treating male androgenetic alopecia (AGA), by comparing its results with finasteride. For this purpose, we enrolled 100 male patients with clinically diagnosed mild to moderate AGA. One group received Serenoa repens 320 mg every day for 24 months, while the other received finasteride 1 mg every day for the same period. In order to assess the efficacy of the treatments, a score index based on the comparison of the global photos taken at the beginning (TO) and at the end (T24) of the treatment, was used. The results showed that only 38% of patients treated with Serenoa repens had an increase in hair growth, while 68% of those treated with finasteride noted an improvement. Moreover finasteride was more effective for more than half of the patients (33 of 50, i.e, 66%), with level II and III alopecia. We can summarize our results by observing that Serenoa repens could lead to an improvement of androgenetic alopecia, while finasteride confirmed its efficacy. We also clinically observed, that finasteride acts in both the front area and the vertex, while Serenoa repens prevalently in the vertex. Obviously other studies will be necessary to clarify the mechanisms that cause the different responses of these two treatments.Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 80% of elderly males (mostly over 60 years old). The onset ofAGA is extremely variable and the physical aspect is characterized by progressive miniaturization of scalp hair follicles (1, 2). Even though this condition is not considered a serious pathology, it is well known that loss of hair leads to stressful events for patients, often with considerable psychosocial consequences. Genetic factors and androgens playa major role in the pathogenesis of the disease. Polymorphism of the androgen receptor genes was first identified in association with androgenetic alopecia. These facts lead to different kinds of AGA patterns that often occur in members of the same families.Anamnesis and clinical examination can lead to the correct diagnosis of AGA, as well as a dermoscopy that can evidence the beginning of the miniaturization of the scalp hair follicles. The presence of more than 20% vellus-like hair in the androgen dependent areas can also lead to diagnosis of initial AGA (3-6).Minoxidil and finasteride are commonly used in treating AGA, both of which have FDA approval; dutasteride, a type I and II 5-alpha-reductase inhibitor, should also be considered and is currently in Phase

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Section: Discussionmentioning

confidence: 99%

Comparitive Effectiveness and Finasteride Vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

Rossi

Mari

Scarnò³

et al. 2012

Int J Immunopathol Pharmacol

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“…Für viele der beschriebenen In-vitro-Wirkungen ist unklar, ob diese auch unter therapeutischer Dosierung in vivo auftreten. So hat unsere Arbeitsgruppe berichtet,dass verschiedene Extrakte aus Sägepalmenfrüchten in vitro eine α 1 -Adrenozeptoren hemmende Wirkung haben, aber diese ließ sich in vivo in Studien an gesunden Probanden nicht belegen [11,12].…”

Section: Extract Of Stinging Nettle Roots (Bazoton ® -Uno) In Long-teunclassified

“…Es wurde daher eine randomisierte,doppelblinde,placebokontrollierte Multicenterstudie bei Patienten mit leichter bis mäßiger obstruktiver und irritativer Symptomatik bei BPS (BPHStadium I und II nach Alken) über einen Behandlungszeitraum von 12 In die Auswertung konnten 226 Patienten des "Intent-to-treat-Kollektivs" (itt) einbezogen werden. Die ±-Angaben im Ergebnisteil beinhalten bezüglich des IPSS den SEM bei Mittelwertangaben, bei Angaben zu maximalen Harnfluss (Q-max) und Restharnbildung (RH) (Median bei nicht normalverteilten Daten) jeweils den SEMD.…”

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Brennnesseltrockenextrakt (Bazoton � -uno) in der Langzeittherapie des benignen Prostatasyndroms (BPS)

Schneider

Rübben

2004

Der Urologe A

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Phytotherapy of BPS has a long tradition in Germany; nevertheless, data referring to single phytotherapeutic agents are rare. We therefore performed a randomized, double-blind, placebo-controlled multicenter study for 1 year with Bazoton uno (459 mg dry extract of stinging nettle roots) with 246 patients. The IPSS decreased on average from 18.7+/-0.3 to 13.0+/-0.5 with a statistically significant difference compared to placebo (18.5+/-0.3 to 13.8+/-0.5; p=0.0233). The median Q(max) increased by 3.0+/-0.4 ml/s in comparison to 2.9+/-0.4 ml/s (placebo), thus not statistically significantly different, as well as the median volume of residual urine, which changed from 35.5+/-3.4 ml before therapy to 20.0+/-2.8 ml and from 40.0+/-4.0 ml to 21.0+/-2.9 ml under placebo application. The number of adverse events (29/38) as well as urinary infections etc. (3/10 events) was smaller under Bazoton uno therapy compared to placebo. Treatment with Bazoton uno can therefore be considered a safe therapeutic option for BPS, especially for reducing irritative symptoms and BPS-associated complications due to the postulated antiphlogistic and antiproliferative effects of the stinging nettle extract. A strong increase of Q(max) or reduction of residual urine are not to be expected.

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“…These may substantially contribute to its therapeutic effect on BPH. Although it inhibits the a 1 -adrenoceptor in vitro, regular doses do not cause a 1 -adrenoceptor antagonism in man in vivo 73 .…”

Section: Saw Palmettomentioning

confidence: 93%

Phytotherapy for prostatism

Xiao

Zhou

2001

The Aging Male

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Phytotherapy has won popular appreciation world-wide in the last few years with advocates proposing that herbs have the advantage of being reasonably effective, of producing fewer side-effects, and of being less costly compared with standard pharmaceutical therapies. PC-SPES is a combination of eight herbs effective for the treatment of prostate cancer patients, including androgen-dependent and androgen-independent cancers, with an overall improvement of morbidity and immune status, even in those in whom conventional therapy has failed. The preparation is estrogenic; however, its therapeutic activity is not only due to its estrogenicity, and the mechanism of action seems to be complicated. The constituent herbs of the preparation possess antitumor, antioxidant, immunomodulatory and anti-inflammatory activities, all of which may contribute to the therapeutic action of PC-SPES on prostate cancer. Further studies are needed to ascertain its long-term effect and safety, and to identify the active compounds and clarify their mechanisms of action.Saw palmetto may have a significant effect on urinary flow rates and symptom scores compared to placebo in men with benign prostatic hyperplasia (BPH) mainly as a result of its 5 -reductase inhibitory activity. Compared with finasteride, saw palmetto produces similar improvement in urinary tract symptoms and urinary flow and is associated with fewer adverse events. Hypoxis rooperi, Secale cereale and Pygeum africanum also appear to somewhat improve BPH symptoms, but the evidence seems less convincing for the use of Urtica dioica or Curcubita pepo alone in the treatment of BPH. The view, that the effects of all the plant products are no better than those of placebo, seems to be a little dogmatic. However, large-scale, placebo-controlled trials using standardized preparations with longer study durations are needed to determine their long-term effectiveness and safety.

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Do saw palmetto extracts block human?1-adrenoceptor subtypes in vivo?

Cited by 20 publications

References 24 publications

Comparitive Effectiveness and Finasteride Vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

Comparitive Effectiveness and Finasteride Vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

Brennnesseltrockenextrakt (Bazoton � -uno) in der Langzeittherapie des benignen Prostatasyndroms (BPS)

Phytotherapy for prostatism

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