“…The BMRC also evaluates strategic preclinical research questions that, if resolved, would facilitate research on important clinical research questions. Some examples of potential SPRQs include needs for refined phenotypes or endophenotypes in research on behavioral and psychosocial risk factors (e.g., Brody, Yu, Barton, Miller, & Chen, 2017; Cuthbert, 2014; Huppertz et al, 2016), questions about biobehavioral mechanisms linking risk factors to medical outcomes (e.g., Cole et al, 2015; Lutgendorf & Andersen, 2015; Miller, Chen, & Parker, 2011; Suls, Green, & Davidson, 2016; Wirtz & von Kanel, 2017), and questions about behavior change processes as applied to behavioral or psychosocial risk factors for chronic medical illnesses (e.g., Brown, Smith, Epton, & Armitage, 2018; Epton, Currie, & Armitage, 2017; E. James et al, 2016; Larsen et al, 2017; Nielsen et al, 2018; Tate et al, 2016; Whelan, Morgan, Sherar, Orme, & Esliger, 2017; Winter, Sheats, & King, 2016).…”