Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort

Archer, Hilary; MacFarlane, F.; Price, Shona L.; Moore, Elizabeth; Pepple, Tracey; Cutler, Dawn; Frost, Chris; Fox, Nick C.; Rossor, Martin N.

doi:10.1002/gps.1644

Cited by 21 publications

(11 citation statements)

References 27 publications

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“…SMC might not only to inform the current well‐being of an individual, but also potentially predict future cognitive trajectory . To date, some groups have found low correlation with objective tests while others have found a significant relationship . To some extent, this could be due to methodological issues, for example, with cross‐sectional designs.…”

Section: Introductionmentioning

confidence: 99%

Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis

Mitchell

Beaumont

Ferguson

et al. 2014

Acta Psychiatr Scand

905

699

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ObjectiveTo investigate if people with subjective memory complaints (SMC) but no objective deficits are at increased risk of developing mild cognitive impairment (MCI) and dementia. MethodsMajor electronic databases were searched till 03/2014 and a meta-analysis was conducted using inception cohort studies. ResultsAcross 28 studies there were 29,723 unique individuals (14,714 with SMC and 15,009 without SMC) (mean 71.6 years) followed on average for 4.8 years through to dementia. The annual conversion rate (ACR) of SMC to dementia was 2.33% (95% CI = 1.93% -2.78%) a relative risk (RR) of 2.07 (95% CI = 1.76 to 2.44) compared to those without SMC (n=15,009). From 11 studies the ACR of developing MCI was 6.67% (95% CI = 4.70 -8.95%).In long-term studies over 5 years, 14.5% (9.67 -19.1%) of people with SMC developed dementia and 26.6% (95% CI =15.3-39.7) went on to develop MCI. The ACR from SMC to dementia and MCI were comparable in community and non-community settings. ConclusionOlder people with SMC but no objective complaints are twice as likely to develop dementia as individuals without SMC. Approximately 2.3% and 6.6% of older people with SMC will progress to dementia and MCI per year. Summations •Among people with SMC but without objective complaints, the annual conversion rate (ACR) to MCI is 6.6%, whilst it is 2.3% to dementia, compared to 1% in those without SMC• Over about 5 years, 24.4% of those with SMC will develop MCI, whilst 10.9% will convert to dementia, compared to 4.6% in those without SMC. 4• Overall, the risk of developing dementia is double in those with SMC compared to those without SMC.• Considerations• It was not possible to stratify the results according to type of dementia or the diagnosis method.• A wide range of definitions were used to capture SMC and it was not possible to conduct subgroup analysis to determine if this influenced the results.• Most of the analysis had high heterogeneity and there was evidence of publication bias in some of the analyses.

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Section: Introductionmentioning

confidence: 99%

Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis

Mitchell

Beaumont

Ferguson

et al. 2014

Acta Psychiatr Scand

905

699

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“…Most studies have attempted to address whether SMC are predictive of future development of dementia rather than associated with current dementia (Jonker et al, 2000). There is uncertainty regarding the relationship between subjective and objective cognitive complaints (Bolla et al, 1991;Taylor et al, 1992;Riedel-Heller et al, 1999Archer et al, 2006;Jama et al, 2006;Reid and MacLullich, 2006). Yet it may be possible to use SMC as a form of initial screening for individuals suffering MCI or dementia.…”

Section: Introductionmentioning

confidence: 99%

The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta‐analysis

Mitchell

2008

Int J Geriat Psychiatry

223

175

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When assessed by simple questions, SMC appear to be present in the minority of those with mild cognitive impairment and dementia. In cross-sectional community settings, even when people agree that they have SMC there is only a 20% or 30% chance that dementia or MCI are present, respectively. Despite this, the absence of SMC may be a reasonable method of excluding dementia and MCI and could be incorporated into short screening programs for dementia and MCI but replication is required in clinical settings.

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“…Studies that have compared the neurocognitive test performances of individuals with SCC relative to controls have most often found numerically lower, although intact, scores (e.g., Nutter-Upham et al, 2008; Peter et al, 2014; Reisberg, Shulman, Torossian, Leng, & Zhu, 2010). Although less frequent, a few studies have found statistically significant differences in cognition between SCC and control groups (e.g., Amariglio et al, 2012; Archer et al, 2006; Buelow, Tremont, Frakey, Grace, & Ott, 2014; Caselli et al, 2014; Dik et al, 2001; Rabin et al, 2006). …”

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confidence: 99%

Everyday functioning and cognitive correlates in healthy older adults with subjective cognitive concerns

McAlister

Schmitter‐Edgecombe

2016

The Clinical Neuropsychologist

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Objective Few studies have examined functional abilities and complaints in healthy older adults with subjective cognitive concerns (SCC). The aims of this study were to assess everyday functioning in healthy older adults reporting high and low amounts of SCC, and examine cognitive correlates of functional abilities. Method Twenty-six healthy older adults with high SCC, and 25 healthy older adults with low SCC, as well as their knowledgeable informants completed the Instrumental Activities of Daily Living-Compensation (IADL-C), a questionnaire measure of everyday functioning. Results After controlling for depression, the high SCC group self-reported significantly more everyday difficulties on the IADL-C, including all subdomains. Compared to the low SCC group, informants for the high SCC group endorsed more difficulties on the IADL-C and specifically the social skills subdomain. For the high SCC group, poorer self-report of everyday functioning was related to poorer executive functioning and temporal order memory. Conclusions These findings indicate that there may be subtle functional changes that occur early in the spectrum of cognitive decline in individuals with high SCC, and these functional changes are evident to informants. Further work is needed to investigate whether individuals with both SCC and functional difficulties are at an even higher risk for progression to mild cognitive impairment.

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Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort

Abstract: The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits.

Cited by 21 publications

References 27 publications

Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis

Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis

The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta‐analysis

Everyday functioning and cognitive correlates in healthy older adults with subjective cognitive concerns

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