2001
DOI: 10.1016/s0268-0033(01)00080-8
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Do the intervertebral disc cells respond to different levels of hydrostatic pressure?

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Cited by 64 publications
(64 citation statements)
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“…The application of a constant hydrostatic pressure has been shown to affect disc cell metabolism in a magnitude-and durationdependent manner. A constant hydrostatic pressure of 0.3-1 MPa increased matrix synthesis in bovine caudal disc tissue, dog IVD cells in alginate and even human pathological disc tissue but hydrostatic pressure higher than 3 MPa was found to induce a catabolic response of the disc cells [36,42,43,46,65].…”
Section: In Vitro Organ Culturementioning
confidence: 94%
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“…The application of a constant hydrostatic pressure has been shown to affect disc cell metabolism in a magnitude-and durationdependent manner. A constant hydrostatic pressure of 0.3-1 MPa increased matrix synthesis in bovine caudal disc tissue, dog IVD cells in alginate and even human pathological disc tissue but hydrostatic pressure higher than 3 MPa was found to induce a catabolic response of the disc cells [36,42,43,46,65].…”
Section: In Vitro Organ Culturementioning
confidence: 94%
“…The influence of static hydrostatic pressure has been studied on isolated human and animal disc cells [42,43,65] (Table 3). The application of a constant hydrostatic pressure has been shown to affect disc cell metabolism in a magnitude-and durationdependent manner.…”
Section: In Vitro Organ Culturementioning
confidence: 99%
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“…For example, 4 h of loading is required to up-regulate aggrecan and collagen I1 levels in the annulus fibrosus, but our results do not indicate whether four 1 h loadings applied over four days would have the same effect. Additionally, while changes in matrix gene expression have been found to correlate well to synthesis levels and protein concentration [8,15,37], mechanical loading has been shown to increase the amount of active enzyme (MMP-2) without affecting mRNA or protein concentrations [13]. Since matrix remodeling is a synergistic relationship between anabolic and catabolic processes, the added effect of enzyme activation makes it difficult to predict the long-term effects of our loading conditions with gene expression alone, and highlights the need for additional long-term studies capable of detecting changes in protein composition.…”
Section: Discussionmentioning
confidence: 99%
“…To elucidate the mechanism by which such degeneration occurs and progresses, several studies have been performed, including in vitro experiments on cultured disc cells [11][12][13] and tissues [17,18,41] under mechanical stresses. The murine tail disc model has been frequently adopted in animal model studies for producing disc degeneration-like changes by the application of artificial mechanical loading because it is inexpensive and convenient to perform.…”
Section: Introductionmentioning
confidence: 99%