Do we need elastography for EUS?

Dietrich, Christoph F.; Burmeister, S.; Hollerbach, Stephan; Arcidiacono, Paolo Giorgio; Braden, Barbara; Fusaroli, Pietro; Hocke, Michael; Iglesias‐García, Julio; Kitano, Masayuki; Larghi, Alberto; Napoléon, Bertrand; Oppong, Kofi; Rimbaș, Mihai; Săftoiu, Adrian; Sahai, Anand V.; Sun, Siyu; Ye, Dong; Carrara, Sandro; Hwang, Joo Ha; Jenssen, Christian

doi:10.4103/eus.eus_25_20

Cited by 33 publications

(23 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, early diagnosis and the follow-up monitoring of COAD/READ remains a challenge due to the lack of early specific symptoms ( 26 ). Colonoscopy is considered the gold standard for detecting and monitoring COAD/READ, but it is an invasive procedure that often causes discomfort and cannot detect metastases early ( 27 , 28 ). Therefore, it is crucial to find new prognostic and therapeutic targets to improve the clinical strategies and outcomes of COAD/READ.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Predicted Significance of FENDRR in Colon and Rectum Adenocarcinoma

2021

Self Cite

View full text Add to dashboard Cite

BackgroundThe role of fetal-lethal non-coding developmental regulatory RNA (FENDRR) has been explored in various cancers; however, its relationship with colon adenocarcinoma/rectum adenocarcinoma (COAD/READ) remains unclear. The objectives of this study were to identify and assess any associations between FENDRR and COAD/READ using The Cancer Genome Atlas (TCGA) database and the Genetic Data Commons (GDC) Data Portal.MethodsThe records of patients with COAD/READ were collected from the GDC Data Portal. After comparing the expression level of FENDRR in COAD/READ and healthy tissues, we evaluated the association of FENDRR with clinicopathological characters and the survival rate, the impact of FENDRR on prognosis, the biological function of FENDRR, and the relative abundance of tumor-infiltrating immune cells in patients with COAD/READ. Moreover, we aimed to construct a protein-protein interaction (PPI) network for selecting genes and a ceRNA network for presenting mRNA-miRNA-lncRNA interactions.ResultsIn patients with COAD/READ, FENDRR expression could differentiate tumor tissues from the adjacent healthy tissues since it was significantly lower in the former than in the latter. High FENDRR expression was correlated with poorer survival and higher tumor stage, current tumor stage, and metastasis stage, and also exhibited high scores for apoptosis, autophagy, and senescence. Immune cell infiltration analysis showed that the high expression group had significantly lower immune and stromal scores. Low FENDRR expression was correlated with poor overall survival (OS), and thus, it could serve as an independent risk factor. The prognostic models constructed in the study performed well for the prediction of OS and disease-specific survival (DFS) using FENDRR expression. Gene set enrichment analysis revealed that vascular smooth muscle contraction, melanogenesis, basal cell carcinoma, and Hedgehog signaling pathways were significantly enriched in patients with high FENDRR expression. Eight hub genes, namely, PKM, ALDOA, PFKP, ALDOC, PYGL, CTNNB1, PSMA5, and WNT5A, were selected from the PPI network, and a ceRNA network was constructed based on the differentially expressed mRNAs, miRNAs, and lncRNAs to illustrate their regulatory relationships.ConclusionFENDRR may serve as a potential biomarker for the diagnosis and prognosis of COAD/READ.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic and Predicted Significance of FENDRR in Colon and Rectum Adenocarcinoma

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…SWE is able to assess the biomechanical properties of tissue; generally, malignant lesions are stiffer than the healthy parenchyma [12][13][14][15][16][17][18][19][20][21][22][23]. Principal applications are: assessment of diffuse pancreatic diseases, e.g., to determine fibrosis and autoimmune diseases [24,25]; characterization of pancreatic lesions as stiff, therefore suspected for pancreatic cancer; guiding biopsy in the stiff part of a focal area; characterization of pancreatic gland stiffness in suspected chronic pancreatitis; evaluation of the pancreatic gland stiffness before surgical resection to predict fistula complication; assessment of the response to treatment of autoimmune pancreatitis.…”

Section: Main Objective Clinical Valuementioning

confidence: 99%

How to perform shear wave elastography. Part II

et al. 2022

Self Cite

View full text Add to dashboard Cite

Recently a series of papers was introduced describing on “how to do” certain techniques. More specifically we published on how to perform strain imaging using the transcutaneous and endoscopic ultrasound approach and shear wave elastography (SWE). In the first part we describe how to optimize the examination technique, discussing normal values, pitfalls, artefacts and specific tips for applying SWE to specific organs (liver, breast, thyroid, salivary glands) as part of a diagnostic US examination. In part II, the use of SWE in the pancreas, spleen, kidney, prostate, scrotum, musculoskeletal system, lymph nodes and future developments are discussed.

show abstract

“…Fibrosis in CP generally results in increased stiffness of the pancreatic parenchyma or ducts, which can be qualitatively or quantitatively evaluated based on strain or shear wave speed using elastography[ 56 , 57 ]. Together, EUS and elastography have been used to quantitatively measure the severity of pathological changes in CP, including parenchymal fibrosis[ 58 ]. EUS elastography (EUS-EG) involves the compression of a target tissue with an echo-endoscopic probe.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

Comprehensive review of diagnostic modalities for early chronic pancreatitis

Ge¹,

Dietrich²,

Bhutani³

et al. 2021

WJG

View full text Add to dashboard Cite

Chronic pancreatitis (CP) is a progressive condition caused by several factors and characterised by pancreatic fibrosis and dysfunction. However, CP is difficult to diagnose at an early stage. Various advanced methods including endoscopic ultrasound based elastography and confocal laser endomicroscopy have been used to diagnose early CP, although no unified diagnostic standards have been established. In the past, the diagnosis was mainly based on imaging, and no comprehensive evaluations were performed. This review describes and compares the advantages and limitations of the traditional and latest diagnostic modalities and suggests guidelines for the standardisation of the methods used to diagnose early CP.

show abstract

Do we need elastography for EUS?

Cited by 33 publications

References 54 publications

Prognostic and Predicted Significance of FENDRR in Colon and Rectum Adenocarcinoma

Prognostic and Predicted Significance of FENDRR in Colon and Rectum Adenocarcinoma

How to perform shear wave elastography. Part II

Comprehensive review of diagnostic modalities for early chronic pancreatitis

Contact Info

Product

Resources

About