Prognostic and Predicted Significance of FENDRR in Colon and Rectum Adenocarcinoma

Abstract

BackgroundThe role of fetal-lethal non-coding developmental regulatory RNA (FENDRR) has been explored in various cancers; however, its relationship with colon adenocarcinoma/rectum adenocarcinoma (COAD/READ) remains unclear. The objectives of this study were to identify and assess any associations between FENDRR and COAD/READ using The Cancer Genome Atlas (TCGA) database and the Genetic Data Commons (GDC) Data Portal.MethodsThe records of patients with COAD/READ were collected from the GDC Data Portal. After comparing the expression level of FENDRR in COAD/READ and healthy tissues, we evaluated the association of FENDRR with clinicopathological characters and the survival rate, the impact of FENDRR on prognosis, the biological function of FENDRR, and the relative abundance of tumor-infiltrating immune cells in patients with COAD/READ. Moreover, we aimed to construct a protein-protein interaction (PPI) network for selecting genes and a ceRNA network for presenting mRNA-miRNA-lncRNA interactions.ResultsIn patients with COAD/READ, FENDRR expression could differentiate tumor tissues from the adjacent healthy tissues since it was significantly lower in the former than in the latter. High FENDRR expression was correlated with poorer survival and higher tumor stage, current tumor stage, and metastasis stage, and also exhibited high scores for apoptosis, autophagy, and senescence. Immune cell infiltration analysis showed that the high expression group had significantly lower immune and stromal scores. Low FENDRR expression was correlated with poor overall survival (OS), and thus, it could serve as an independent risk factor. The prognostic models constructed in the study performed well for the prediction of OS and disease-specific survival (DFS) using FENDRR expression. Gene set enrichment analysis revealed that vascular smooth muscle contraction, melanogenesis, basal cell carcinoma, and Hedgehog signaling pathways were significantly enriched in patients with high FENDRR expression. Eight hub genes, namely, PKM, ALDOA, PFKP, ALDOC, PYGL, CTNNB1, PSMA5, and WNT5A, were selected from the PPI network, and a ceRNA network was constructed based on the differentially expressed mRNAs, miRNAs, and lncRNAs to illustrate their regulatory relationships.ConclusionFENDRR may serve as a potential biomarker for the diagnosis and prognosis of COAD/READ.

Analysis of disulfidptosis‐ and cuproptosis‐related LncRNAs in modulating the immune microenvironment and chemosensitivity in colon adenocarcinoma

“…For example, SNHG7 has been shown to enhance the invasiveness and migratory abilities of gastric cancer cells by inhibiting the miR-34a-Snail-EMT axis [20]. FENDRR, on the other hand, has demonstrated associations with various clinical characteristics in different cancers and has exhibited potential as a novel diagnostic and prognostic biomarker [21,22]. Further evidence suggests that FENDRR acts as a miRNA sponge for miR-214-3p, thereby suppressing the progression of gastric cancer [23].…”

Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA

“…In breast cancer, FENDRR inhibits cell proliferation and is associated with a good prognosis [ 35 ]. In colorectal adenocarcinoma, the high FENDRR expression indicates a poor survival rate and promotes autophagy, apoptosis, and aging [ 36 ]. LINC02381 can be used as an oncogenic lncRNA and a tumor suppressor in cancer.…”

Low Expression of AGPAT5 Is Associated With Clinical Stage and Poor Prognosis in Colorectal Cancer and Contributes to Tumour Progression

“…8 Foetal-lethal noncoding developmental regulatory RNA (FENDRR) has been reported as a potential biomarker for the diagnosis and prognosis of CRC. 9 However, these biomarkers have not been identified for their potential clinical significance in CRC.…”