Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study

Smith, Vanessa; Decuman, Saskia; Sulli, Alberto; Bonroy, Carolien; Piettte, Yves; Deschepper, Ellen; Keyser, Filip De; Cutolo, Maurizio

doi:10.1136/annrheumdis-2011-200780

Cited by 152 publications

(143 citation statements)

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“…These observations confirm the results of a recent longitudinal study that reported a dynamic transition of microvascular damage through different capillaroscopy patterns in nearly 50% of SSc patients (Smith et al, 2012;Sulli et al, 2012).…”

Section: Discussionsupporting

confidence: 91%

“…In order to clarify with further aspects the reported associations between nailfold capillary abnormalities and clinical and/or laboratory features (Bredemeier et al, 2004;Caramaschi et al, 2007;Chen et al, 1984;Cutolo et al, 2004;Hofstee et al, 2009;Lovy et al, 1985;Smith et al, 2012;Sulli et al, 2012) it was decided to evaluate a large multinational group of patients with SSc such as the international multicenter cohort of the EULAR Scleroderma Trials And Research (EUSTAR) registry.…”

Section: Introductionmentioning

confidence: 99%

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Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Ingegnoli

Ardoino

Boracchi

et al. 2013

Microvascular Research

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104

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Ingegnoli

Ardoino

Boracchi

et al. 2013

Microvascular Research

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104

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“…We considered an organ system to be involved if the corresponding disease severity score was Ն1 (16). Severe organ involvement was defined as a disease severity score of Ն2 (17). Lung involvement was assessed by high-resolution computed tomography (HRCT) and pulmonary function testing.…”

Section: Methodsmentioning

confidence: 99%

Growth Differentiation Factor 15, a Marker of Lung Involvement in Systemic Sclerosis, Is Involved in Fibrosis Development but Is not Indispensable for Fibrosis Development

Lambrecht

Smith

Wilde

et al. 2014

Arthritis & Rheumatology

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ObjectiveTransforming growth factor β superfamily members are involved in the pathogenesis of systemic sclerosis (SSc). Growth differentiation factor 15 (GDF‐15) is a distant member of this family. We undertook this study to evaluate the role of GDF‐15 in SSc pathogenesis.MethodsA longitudinal prospective cohort of SSc patients was screened for serum GDF‐15 levels using enzyme‐linked immunosorbent assay, and associations with clinical data were analyzed. In vitro stimulation experiments were performed on lung fibroblasts. The role of GDF‐15 in fibrosis development in vivo was evaluated in the bleomycin lung fibrosis model in GDF‐15–deficient mice.ResultsGDF‐15 was measured at baseline in serum samples from 119 SSc patients. An increase in GDF‐15 levels was observed in patients classified as having no skin involvement, those with limited cutaneous SSc, and those with diffuse cutaneous SSc. Moreover, baseline serum GDF‐15 levels correlated strongly with disease activity and extent of organ involvement, particularly clinical symptoms of lung fibrosis, including impact on lung function at prospective followup. This was mimicked in the bleomycin model of SSc, in which animals exposed to bleomycin had elevated expression levels of GDF‐15 in lung tissue. Lung fibroblasts isolated from GDF‐15–deficient mice showed reduced induction of interleukin‐6 and CCL2 upon bleomycin stimulation. Surprisingly, no differences in fibrosis development were observed between wild‐type and GDF‐15–deficient animals.ConclusionAn intriguing profile of serum GDF‐15 levels was found in SSc patients. GDF‐15 expression is induced during fibrosis development and markedly correlates with lung function impairment in this disease. The protein may participate in fibrosis initiation, but is not indispensable in the course of fibrosis development in vivo.

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“…It has been reported that the decreased number of capillaries is associated with clinical subsets and the severity of SSc clinical complications 2,3,4,5 .…”

Section: To the Editormentioning

confidence: 99%

Progression of Organ Involvement in Systemic Sclerosis Patients with Persistent “Late” Nailfold Capillaroscopic Pattern of Microangiopathy: A Prospective Study

et al. 2017

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Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study

Abstract: This pilot study is the first demonstrating an association between baseline NVC patterns and future severe, peripheral vascular and lung involvement with stronger odds according to worsening scleroderma patterns. This may indicate a putative role of capillaroscopy as a biomarker.

Cited by 152 publications

References 12 publications

Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Growth Differentiation Factor 15, a Marker of Lung Involvement in Systemic Sclerosis, Is Involved in Fibrosis Development but Is not Indispensable for Fibrosis Development

Progression of Organ Involvement in Systemic Sclerosis Patients with Persistent “Late” Nailfold Capillaroscopic Pattern of Microangiopathy: A Prospective Study

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