1995
DOI: 10.1002/1097-0142(19950701)76:1<110::aid-cncr2820760117>3.0.co;2-9
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Docetaxel (Taxotere) associated scleroderma-like changes of the lower extremities. A report of three cases

Abstract: Background. Docetaxel (Taxotere) is a microtubule‐stabilizing agent that is potentially important in chemotherapy for a variety of malignancies. Methods. A clinical study of the cutaneous reactions experienced by a group of patients receiving docetaxel chemotherapy was undertaken. Patients were examined before initiation of therapy, before and after each cycle of therapy, and were followed subsequent to the completion of docetaxel chemotherapy. Results. Three patients developed diffuse lower extremity edema (3… Show more

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Cited by 72 publications
(75 citation statements)
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“…Histology evidenced scleroderma-like changes but no biological features of systemic scleroderma were observed. Resolution of both the edema and the cutaneous alterations was observed after the discontinuation of docetaxel [1]. Scleroderma-like cutaneous changes have already been reported after exposure to various organic solvents (polyvinyl chloride, benzene, toluene), drugs (bleomycin, carbidopa, pentazocine, isoniazid, valproic acid, bromocriptine, nitrofurantoin, penicillamine, diltiazem, fosinopril, cocaine) and miscellaneous substances (rapeseed oil/aniline, silicon dioxide, L-tryptophan, taxanes, topotecan) [17].…”
Section: Discussionmentioning
confidence: 92%
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“…Histology evidenced scleroderma-like changes but no biological features of systemic scleroderma were observed. Resolution of both the edema and the cutaneous alterations was observed after the discontinuation of docetaxel [1]. Scleroderma-like cutaneous changes have already been reported after exposure to various organic solvents (polyvinyl chloride, benzene, toluene), drugs (bleomycin, carbidopa, pentazocine, isoniazid, valproic acid, bromocriptine, nitrofurantoin, penicillamine, diltiazem, fosinopril, cocaine) and miscellaneous substances (rapeseed oil/aniline, silicon dioxide, L-tryptophan, taxanes, topotecan) [17].…”
Section: Discussionmentioning
confidence: 92%
“…Scleroderma-like skin changes were first reported in patients treated by docetaxel who developed a lower limbs or a generalized edema followed by a thickening of the skin [1]. Histology evidenced scleroderma-like changes but no biological features of systemic scleroderma were observed.…”
Section: Discussionmentioning
confidence: 96%
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“…Rubin et al [26] Extremitäten lokalisiert wurde beschrieben [1]. Zunächst entsteht ein Ödem, anschließend eine Induration, die sich nach Therapieende innerhalb 1 Jahres zurückbildet.…”
Section: Introductionunclassified
“…zum Abbruch der zytostatischen Behandlung führten. Erythematöse Veränderungen traten bei 60-70% der Patienten auf[1,13,15,21,34]. Die maximale Ausprägung des Erythems zeigte sich 2-4 Tage nach Gabe von Docetaxel.…”
unclassified