Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer

Manni, Andrea; El‐Bayoumy, Karam; Thompson, Henry J.

doi:10.3390/ijms19010028

Cited by 14 publications

(8 citation statements)

References 75 publications

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“…However, a diet rich in added sugars (sucrose and fructose) induces a reduction of ω-3 PUFA neuroprotective activity, resulting in increased neuroinflammation, reduced neurogenesis and cognitive deficits [117]. Finally, by combining DHA supplementation with dietary energy restriction, BC-related obesity can be counteracted, for the dual effect on fatty acid metabolism and cell growth pathways, leading to inhibition of cell proliferation and induction of apoptosis; however, the effects in humans have to be proven [118]. Thus, for improvement of patient quality of life, it is possible that EPA and/or DHA will soon be recommended as adjuvants for chemotherapy and radiotherapy in BC patients.…”

Section: Nutritional Interventions During Bc Treatmentmentioning

confidence: 99%

Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence

et al. 2019

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Breast cancer (BC) is the second most common cancer worldwide and the most commonly occurring malignancy in women. There is growing evidence that lifestyle factors, including diet, body weight and physical activity, may be associated with higher BC risk. However, the effect of dietary factors on BC recurrence and mortality is not clearly understood. Here, we provide an overview of the current evidence obtained from the PubMed databases in the last decade, assessing dietary patterns, as well as the consumption of specific food-stuffs/food-nutrients, in relation to BC incidence, recurrence and survival. Data from the published literature suggest that a healthy dietary pattern characterized by high intake of unrefined cereals, vegetables, fruit, nuts and olive oil, and a moderate/low consumption of saturated fatty acids and red meat, might improve overall survival after diagnosis of BC. BC patients undergoing chemotherapy and/or radiotherapy experience a variety of symptoms that worsen patient quality of life. Studies investigating nutritional interventions during BC treatment have shown that nutritional counselling and supplementation with some dietary constituents, such as EPA and/or DHA, might be useful in limiting drug-induced side effects, as well as in enhancing therapeutic efficacy. Therefore, nutritional intervention in BC patients may be considered an integral part of the multimodal therapeutic approach. However, further research utilizing dietary interventions in large clinical trials is required to definitively establish effective interventions in these patients, to improve long-term survival and quality of life.

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Section: Nutritional Interventions During Bc Treatmentmentioning

confidence: 99%

Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence

et al. 2019

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“…Therefore, DHA appears as a safe, natural compound that can greatly improve the anticancer properties of anticancer drugs by additive or synergistic interactions [14,45,46]. In addition, n-3 PUFA reduced the risk of obesity-related breast cancer [47] and had protective effects towards the cardiotoxicity of anthracyclines, the most extensively used chemotherapeutics [48,49]. Thus, current results of cohort studies and investigations in cell lines or animal models demonstrated that DHA could reduce tumor cell number by acting as soon as the cell begins its neoplastic transformation through a decrease in proliferation and an increase in apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Response of Breast Cancer Cells MDA-MB-231 to Docosahexaenoic Acid: Downregulation of Lipid and Cholesterol Metabolism Genes and Upregulation of Genes of the Pro-Apoptotic ER-Stress Pathway

Chénais

Cornec

Dumont

et al. 2020

IJERPH

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Despite considerable efforts in prevention and therapy, breast cancer remains a major public health concern worldwide. Numerous studies using breast cancer cell lines have shown the antiproliferative and pro-apoptotic effects of docosahexaenoic acid (DHA). Some studies have also demonstrated the inhibitory effect of DHA on the migration and invasion of breast cancer cells, making DHA a potential anti-metastatic agent. Thus, DHA has shown its potential as a chemotherapeutic adjuvant. However, the molecular mechanisms triggering DHA effects remain unclear, and the aim of this study was to provide a transcriptomic basis for further cellular and molecular investigations. Therefore, MDA-MB-231 cells were treated with 100 µM DHA for 12 h or 24 h before RNA-seq analysis. The results show the great impact of DHA-treatment on the transcriptome, especially after 24 h of treatment. The impact of DHA is particularly visible in genes involved in the cholesterol biosynthesis pathway that is strongly downregulated, and the endoplasmic reticulum (ER)-stress response that is, conversely, upregulated. This ER-stress and unfolded protein response could explain the pro-apoptotic effect of DHA. The expression of genes related to migration and invasion (especially SERPINE1, PLAT, and MMP11) is also impacted by DHA. In conclusion, this transcriptomic analysis supports the antiproliferative, pro-apoptotic and anti-invasive effects of DHA, and provides new avenues for understanding its molecular mechanisms.

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“…Docosahexaenoic acid (DHA) has a high medical and nutritional value; it promotes visual acuity and neural development (Boelen et al 2013 ), and reduces the risk of some diseases such as cardiovascular, arthritis, diabetes, and obesity related breast cancer (Biscione et al 2007 ; Lee et al 2012 ; Manni et al 2017 ). As a result, DHA has received worldwide attention in past decades.…”

Section: Introductionmentioning

confidence: 99%

Effect of cultivation mode on the production of docosahexaenoic acid by Tisochrysis lutea

Shen

et al. 2018

AMB Expr

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In this study, Tisochrysis lutea was cultivated in mixotrophic and heterotrophic cultures with glycerol as a carbon source and with glucose and acetate for comparison; autotrophic cultivation was the control group without a carbon source. It was found that T. lutea used glycerol and did not use glucose and acetate under mixotrophy. Mixotrophy slightly elevated the docosahexaenoic acid (DHA) and total fatty acids (TFA) content in the dry-weight and enhanced the DHA and TFA production in medium (41.3 and 31.9% respectively) at the end of a 16-day cultivation, while heterotrophy reduced the DHA content and TFA production. Under the mixotrophy, the glycerol contribution to the DHA production (16.19 mg/L) and the TFA production (97.8 mg/L) was not very high and the DHA yield [2.63% chemical oxygen demand (COD)] and TFA yield (13.1% COD) were also very low. Furthermore, T. lutea using glycerol had a period of adaptation, indicating that T. lutea was not an ideal microalga for organic carbon utilization.Electronic supplementary materialThe online version of this article (10.1186/s13568-018-0580-9) contains supplementary material, which is available to authorized users.

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Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer

Cited by 14 publications

References 75 publications

Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence

Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence

Transcriptomic Response of Breast Cancer Cells MDA-MB-231 to Docosahexaenoic Acid: Downregulation of Lipid and Cholesterol Metabolism Genes and Upregulation of Genes of the Pro-Apoptotic ER-Stress Pathway

Effect of cultivation mode on the production of docosahexaenoic acid by Tisochrysis lutea

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