Documenta Geigy

In the ovariectomized rat, the adrenal gland secretes progesterone. Adrenocorticotropin treatment elevates concentrations of this steroid in plasma, and inhibitors of adrenocorticotropin or progesterone biosynthesis lower the concentration. Adrenocorticotropin controls progesterone secretion by the adrenal but not by the ovary. Adrenal progesterone and its mode of control may have important influences on reproductive processes.

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Growth Inhibition Among Strains of Neisseria gonorrhoeae due to Production of Inhibitory Free Fatty Acids and Lysophosphatidylethanolamine: Absence of Bacteriocins

Walstad

Reitz

Sparling

1974

Infect Immun

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Each of 50 tested strains of Neisseria gonorrhoeae produced growth-inhibitory substances that were active against most strains of gonococci or meningococci, but not against species other than the Neisseria. There were quantitative differences among different strains in production of the inhibitor and sensitivity to it, but not of sufficient magnitude to permit routine strain typing. The inhibitor was associated with the cell pellet (crude cell envelope) and was not inducible with mitomycin C. Inhibitory activity was thermostable and resisted alkali and proteolytic enzymes. The inhibitor was quantitatively recovered from whole cells by chloroform-methanol extraction. Separation of total gonococcal lipids by silica gel chromatography revealed inhibitory activity in both the free fatty acid and the phospholipid fractions. The major phospholipid, phosphatidylethanolamine, had no inhibitory activity, but monoacyl phosphatidylethanolamine, a minor phospholipid, was quite inhibitory. It is likely that the “bacteriocin” of N. gonorrhoeae strains results from the degradation of phosphatidylethanolamine to inhibitory long-chain free fatty acids and monoacyl phosphatidylethanolamine.

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Documenta Geigy

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De l'effet sur la kátine de la laine, de certaines matiès ajoutś dans les detergents

De l'effet sur la kátine de la laine, de certaines matiès ajoutś dans les detergents

Endocrine Control of Adrenal Progesterone Secretion in the Ovariectomized Rat

Growth Inhibition Among Strains of Neisseria gonorrhoeae due to Production of Inhibitory Free Fatty Acids and Lysophosphatidylethanolamine: Absence of Bacteriocins

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