Following the European guidelines, research in the architecture sector has been committed to seeking open systems, which can be implemented in stages for structuring methodological protocols applicable to digitization to enhance Cultural Heritage. The H2020-RISE-PROMETHEUS project, coordinated by the University of Pavia, aims to define a multi-scalar digital information system to safeguard the historical memory of the heritage and promote Cultural Heritage Routes. That allows the dissemination of the heritage architectural diffuse of the European Cultural Heritage Routes, starting from the pilot case of the Upper Kama territory (Russia). The languages of representation and the analysis processes of the elements result from an international collaboration between universities and companies in a critical, shared process of evaluating the criteria for optimizing infographic languages. The research results are explained in the information modeling protocol, structured based on an analytical approach of morphological, technological, and typological semantization, from the territorial level to the architectural scale, for the combined management of historical memory, information, and intervention on the work.