Does adding endometrial scratching to diagnostic hysteroscopy improve pregnancy rates in women with recurrent in-vitro fertilization failure?

Seval, Mehmet Murat; Şükür, Yavuz Emre; Özmen, Batuhan; Kan, Özgür; Sönmezer, Murat; Berker, Bülent

doi:10.1080/09513590.2016.1190818

Cited by 28 publications

(18 citation statements)

References 27 publications

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“…Shohayeb et al [8] reported that a single endometrial biopsy (endometrial scratching) during HSC was associated with a significantly higher implantation rate, clinical pregnancy rate, and live birth rate after ICSI than if a biopsy was not performed. Similarly, Seval et al [40] reported that “endometrial scratching” during HSC improved the implantation and pregnancy rates in women with RIF as compared to HSC alone. Recently, a Cochrane review also recommend the beneficial effects of scratching.…”

Section: Discussionmentioning

confidence: 99%

Effect of hysteroscopy before starting in-vitro fertilization for women with recurrent implantation failure

Mao

Chen

et al. 2019

Medicine

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Objective: To study if hysteroscopy (HSC) before starting an in-vitro fertilization (IVF) cycle improves IVF outcomes in women with recurrent implantation failure (RIF). Methods: The Medline, Cochrane, EMBASE, and Google Scholar databases were searched using the following keywords until March 31, 2017: in-vitro fertilization; infertility; hysteroscopy; recurrence; embryo implantation; and pregnancy. Randomized controlled trials (RCTs), two-arm prospective studies, and retrospective studies were included. Results: Three RCTs, 3 nonrandomized prospective studies, and 2 retrospective cohort studies were included. The eligible studies included 3932 women with RIF: 1841 in the HSC group and 2091 in the control group. The clinical pregnancy rate and implantation rate was significantly higher in the HSC group compared with the control group (for clinical pregnancy rate, pooled odds ratio [OR] = 1.64, 95% confidence intervals [CI]: 1.30–2.07, P < 0.001; for implantation rate, pooled OR = 1.22, 95% CI: 1.02–1.45, P = 0.025). The live birth rate (pooled OR = 1.30, 95% CI: 0.90–1.88, P = 0.168) and the miscarriage rate (pooled OR = 0.94, 95% CI: 0.66–1.35, P = 0.744) of the 2 groups were not statistically significantly. Conclusions: HSC improved the implantation rate and clinical pregnancy rates, but failed to improve live birth rate and did not affect the miscarriage rate in women with RIF undergoing IVF. Since HSC plays a significant role in pregnancy and birth outcomes of women with RIF, further studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Effect of hysteroscopy before starting in-vitro fertilization for women with recurrent implantation failure

Mao

Chen

et al. 2019

Medicine

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“…This will permit the monitoring of the microbiota and endometrial tissue responses during assisted reproductive treatment cycles. There is already a common practice of endometrial scratching (reviewed,) during the menstrual cycle prior to embryo transfer. We propose scratching material could be harvested and tested for the endometrial microbiota and expression of select endometrial genes to optimise embryo transfer timing.…”

Section: Discussionmentioning

confidence: 99%

A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women

Wee

Thomas

Sweeney

et al. 2017

Aust NZ J Obst Gynaeco

126

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“…Three latest studies which compared hysteroscopical groups with and without endometrial lesion, produced opposing results. Seval et al 14 stated significantly higher rates of implantation and rates of pregnancy with the LEI groups, before IVF whereas El-Khayat et al 13 and Shokeir et al 12 , examining the natural cycle and cycles with artificial insemination, did not find any justification to perform endometrial lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have tried to show that local endometrial injury (LEI) prior to IVF leads to an inflammatory response causing an increased endometrial receptivity and bigger IVF success rate [3][4][5] . In the majority of studies, LEI was made on the front or the back of uterus wall 6 , using Pippele biopsy catheter [7][8][9] , Novak biopsy catheter 10 or endometrial cell sampler 11 ; in smaller number of studies, LEI was made during hysteroscopy using grasping forceps 12,13 or monopolar electrode 14 .…”

Section: Introductionmentioning

confidence: 99%

The effects of local endometrial injury by hysteroscopy on in vitro fertilization outcome

et al. 2018

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Bacngraund/Aim. Regardless of embryos quality, an appropriate endometrial thickness and a successful embryo transfer (ET), implantation remains a difficulty for a favorable outcome of an in vitro fertilization (IVF). Numerous studies with the aim of increasing implantation rate and pregnancy rate suggest local endometrial injury (LEI) prior to the IVF procedure. Hysteroscopy is a method becoming more widely used both with patients after a failed IVF cycle and with patients before the first IVF, considering the large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. However, there is still no consensus reached over LEI, the way and time of its performing or its impact. The aim of this research was to determine the effect of hysteroscopically made local endometrial lesion on the IVF procedure outcome, both in the first and in the next IVF cycle and also to examine if the new method of LEI provoking using bipolare electrode has a favorable impact on post IVF pregnancy success. Methods. Total of 81 patients had hysteroscopy performed 30-50 days prior to IVF, 40 of which had LEI made during hysteroscopy (the LEI group) using bipolar electrode in a way not described in any available literature. Remaning his-teroscopically treated patients (n = 41) had no LEI (the non-LEI group). The control group included 151 patient who had IVF performed with no prior hysteroscopy and LEI. Results. The rate of clinical pregnancies after LEI was statistically more significant in comparison to the control group (52.50% vs 34.44%, p < 0.05) and it meant 2.1 time bigger chance to conceive (OR=2.10; 95% CI: 1.04-4.26; p < 0.05). We noticed differences in the implantation rate between the LEI group and the non-LEI group on one side and the control group on the other, in favor of the two groups subjected to hysteroscopy (23.89%, 25.47% vs 18.18%, respectively), but they were not of any statistical significance. Not significantly higher rate of pregnancy was present, after the first and the next IVF, both in the LEI and the non-LEI group when compared to the control one. Conclusion. New method of LEI provoking by bipolar electrode in the process of hysteroscopy is a simple and safe method allowing higher rate of clinical pregnancies and doubling the probabilty of the positive IVF outcome.

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Does adding endometrial scratching to diagnostic hysteroscopy improve pregnancy rates in women with recurrent in-vitro fertilization failure?

Abstract: Endometrial scratching during diagnostic hysteroscopy seems to enhance implantation and as well pregnancy rates in comparison to diagnostic hysteroscopy alone.

Cited by 28 publications

References 27 publications

Effect of hysteroscopy before starting in-vitro fertilization for women with recurrent implantation failure

Effect of hysteroscopy before starting in-vitro fertilization for women with recurrent implantation failure

A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women

The effects of local endometrial injury by hysteroscopy on in vitro fertilization outcome

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