Does Aging Affect the Response of Vitamin E Status to Vitamin E Depletion and Supplementation?

Winklhofer‐Roob, Brigitte M.; Roob, Johannes M.; Maritschnegg, M; Sprinz, Grete; Hiller, D.; Marktfelder, E.; Preinsberger, M.; Wuga, Sandra; Sundl, Isabella; Tiran, Beate; Cardinault, Nicolas; Ribalta, Josep; Rock, Edmond

doi:10.1196/annals.1331.050

Cited by 4 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to vitamin C, linear age is an independent positive determinant of both plasma α-tocopherol and α-tocopherol/cholesterol ratio along the course of ageing, which is in line with results from several previous studies reporting an increase of plasma α-tocopherol with increasing age [ 44 , 45 , 46 , 47 , 48 , 49 ]. However, none of these studies used multiple follow-ups and allowed to investigate non-linear trajectories of plasma α-tocopherol and/or α-tocopherol/cholesterol ratio in the course of ageing.…”

Section: Discussionsupporting

confidence: 90%

Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades

Jungert

Neuhäuser‐Berthold

2020

Nutrients

View full text Add to dashboard Cite

Although the interrelation between vitamins C and E has been demonstrated on an experimental level, its impact on biomarkers in community-dwelling subjects along the trajectory of ageing has not yet been shown. The present longitudinal study investigates the determinants and interrelation of vitamins C and E plasma concentrations in 399 subjects aged ≥60 years with a median follow-up time of 12 years. Linear mixed-effects models were used to analyze the influence of age, sex, body composition, dietary intake, physical activity, smoking and supplement/drug use on plasma vitamin C, plasma α-tocopherol and α-tocopherol/total cholesterol ratio. At baseline, median plasma concentrations of vitamin C and α-tocopherol were 74 and 35 µmol/L. Absolute fat-free mass, physical activity, use of supplements, and plasma α-tocopherol were main determinants of plasma vitamin C in the course of ageing. For the α-tocopherol/total cholesterol ratio, age, use of supplements, use of lipid-modifying drugs, and plasma vitamin C were main determinants. The results reveal a stable positive interrelation between plasma concentrations of vitamins C and E along the trajectory of ageing independent of the other identified determinants. The possible regulatory mechanisms that could explain this robust positive interrelation remain to be elucidated.

show abstract

Section: Discussionsupporting

confidence: 90%

Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades

Jungert

Neuhäuser‐Berthold

2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Different aged individuals respond differently to various food and vitamin supplementation [25]. Needs for supplement may be different with the different age where older people may benefit from supplementation as they were reported to have lower antioxidant levels [26].…”

Section: Introductionmentioning

confidence: 99%

Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

et al. 2011

View full text Add to dashboard Cite

BackgroundVitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.MethodsSixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3rd and 6th months.ResultsHDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the > 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the > 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the > 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).ConclusionThe observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.

show abstract

Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects

Borel

Dangles

Kopec

2023

Progress in Lipid Research

View full text Add to dashboard Cite

Does Aging Affect the Response of Vitamin E Status to Vitamin E Depletion and Supplementation?

Cited by 4 publications

References 10 publications

Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades

Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades

Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects

Contact Info

Product

Resources

About