Does aging influence pancreatic response in the ultrasound secretin test by impairing hydrokinetic exocrine function or sphincter of Oddi motor function?

Glaser, Joachim; Stienecker, Klaus

doi:10.1016/s1590-8658(00)80040-7

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…Data on the effect of ageing on the secretory capacity of the exocrine pancreas are inconsistent ( Table 2). In a first study, the response to secretin stimulation in terms of hydrokinetic pancreatic function, sphincter of Oddi motor function and extensibility of Wirsung's duct was investigated, and none of the parameters proved to be affected by age [63]. The fluorescein dilaurate test reported no decrease in exocrine pancreatic function measured in individuals aged 66-88 years [64]; however, this test is notoriously inconsistent and therefore no longer available [65,66].…”

Section: Age-related Changes In Pancreatic Functionmentioning

confidence: 99%

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

et al. 2018

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Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20 and 60 years, and declines thereafter. This decline involves the pancreatic parenchyma and is associated with decreased perfusion, fibrosis and atrophy. As a consequence of these changes, pancreatic exocrine function is impaired in healthy older individuals without any gastrointestinal disease. Five per cent of people older than 70 years and ten per cent older than 80 years have pancreatic exocrine insufficiency (PEI) with a faecal elastase-1 below 200 μg g stool, and 5% have severe PEI with faecal elastase-1 below 100 μg g stool. This may lead to maldigestion and malnutrition. Patients may have few symptoms, for example steatorrhoea, diarrhoea, abdominal pain and weight loss. Malnutrition consists of deficits of fat-soluble vitamins and is affecting both patients with PEI and the elderly. Secondary consequences may include decreased bone mineral density and results from impaired absorption of fat-soluble vitamin D due to impaired pancreatic exocrine function. The unanswered question is whether this age-related decrease in pancreatic function warrants therapy. Therapeutic intervention, which may consist of supplementation of pancreatic enzymes and/or vitamins in aged individuals with proven exocrine pancreas insufficiency, could contribute to healthy ageing.

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Section: Age-related Changes In Pancreatic Functionmentioning

confidence: 99%

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

et al. 2018

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“…51 Parenchymal perfusion of the normal human pancreas can be evaluated using dynamic computed tomography. 54 Neither the relative weight of the lobe rich in pancreatic polypeptide cells (PP) nor the volume density of polypeptide cells varies significantly with aging. In this study, pancreatic parenchymal density was not correlated with perfusion nor with age.…”

Section: Morphological and Functional Changesmentioning

confidence: 99%

Age-related changes in liver, gall bladder and pancreas

Wynne

2002

Rev. Clin. Gerontol.

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Although a reduced liver size in elderly people has long been recognized from post-mortem studies, these studies do not allow the separation of true ‘age-related’ differences from the effects of premorbid illness, and death. An age-related effect was confirmed however by an in vivo study which measured liver size by ultrasound scanning of healthy individuals. This demonstrated a significant negative correlation between age and liver volume, with volumes being 28% lower in individuals above the age of 65 compared with those under 40 years of age.

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Pancreas

Amin¹

2011

Clinical Ultrasound

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Does aging influence pancreatic response in the ultrasound secretin test by impairing hydrokinetic exocrine function or sphincter of Oddi motor function?

Cited by 9 publications

References 18 publications

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

Age-related changes in liver, gall bladder and pancreas

Pancreas

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