Does alcohol have any effect on male reproductive function? A review of literature

Vignera, Sandro La; Condorelli, Rosita A.; Balercia, Giancarlo; Vicari, Enzo; Calogero, Aldo E.

doi:10.1038/aja.2012.118

Cited by 148 publications

(96 citation statements)

References 34 publications

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“…It is reported that 75% of children with fetal alcohol syndrome have fathers who were alcoholics [120]. Alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation [121]. Although, paternal alcohol consumption has been shown to affect the growth and behavior of the offspring, the mechanisms underlying these effects still remain to be elucidated.…”

Section: Consumption Of Alcoholmentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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Infertility has become ominous problem. On an average, about 10% of all couples face difficulty in starting a family and this creates a feeling of great personal failure, particularly in India where religious and socio-economic traditions have made it almost imperative for everyone to have children. A significant association had been found between impaired semen quality including sperm count, motility and morphology. In this review, the various contributory etiological factors i.e., exposure to heavy metals, pesticides, industrial chemicals, endocrine factors, genetics causes and modern life style had been discussed which have a serious impact on male infertility. In this article we analyzed data from different sources and present evidences of the possible etiology and risk factors for male infertility. There is a need to emerge at the indiscriminate use and disposal of environmental chemicals. Especially pesticides and industrial chemicals as the chemicals enter the food chain, surface and ground water which had potential for exposure during the critical period of development further avoiding tobacco smoking, excessive alcoholism, excessive heat exposure to the testes can help in improving the semen quality.

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Section: Consumption Of Alcoholmentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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“…Further, caffeine intake in women prior to pregnancy has not been conclusively shown to affect fertility; however, it may increase their risk for spontaneous abortion in the first trimester (29)(30)(31). Even though there is conflicting evidence in the literature about the effects of substance use and fertility, it is recommended that men and women cease use of these substances for fertility, preconception health, and overall good health (6,17,18,21,23,24,32).…”

Section: Effects Of Substance Use On Reproductive Healthmentioning

confidence: 99%

“…Much like male fertility, evidence is not conclusive as to whether alcohol consumption has an impact on female fertility (21,22). There is evidence, however, that excessive alcohol intake in males is associated with testicular atrophy, decreased libido, erectile dysfunction, and reduced effectiveness of assisted reproductive technology (ART) procedures (17,23,24). Although the evidence was minimal, anabolic steroids and recreational drugs can cause damage to sperm, but the sperm may recover with discontinuation of use of steroids and drugs (17).…”

Section: Effects Of Substance Use On Reproductive Healthmentioning

confidence: 99%

Substance Use and Preconception Care: A Review of the Literature

Ricks¹,

Comer²,

Liu³

et al. 2017

IJWHR

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“…A complete medical history was collected and all of them underwent a careful physical examination and laboratory and ultrasound instrumental evaluation. Men with male accessory gland infection (4), systemic diseases (5, 6), microorchidism (testicular volume <12 ml) (7), history positive for cryptorchidism (8) or varicocele (9), drug and/or alcohol use/abuse (10), and recent «12 months) hormonal treatments were excluded. The protocol was approved by the internal Institutional Review Board and an informed written consent was obtained from each patient.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Effects of Nicotine on Sperm Motility and Bio-Functional Flow Cytometry Sperm Parameters

Condorelli

Vignera

Giacone

et al. 2013

Int J Immunopathol Pharmacol

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The aim of this experimental study was to evaluate the effects of nicotine on sperm motility and on nonconventional sperm parameters in vitro. Capacitated spermatozoa isolated from 10 normozoospermic, healthy, non-smoker men were evaluated. Spermatozoa were exposed to increasing concentrations of nicotine (0, 1, 10, and 100 nglml) for 3 and 24 hours. Progressive motility and the following nonconventional sperm parameters, evaluated by flow cytometry, were assessed: mitochondrial membrane potential, viability, phosphatidylserine externalization, late apoptosis, degree of chromatin compactness, and DNA fragmentation. Nicotine suppressed, in a concentration-dependent manner, sperm progressive motility starting from the lowest concentration used (1 ng/ml), Similarly, it reduced the percentage of viable spermatozoa and increased the number of spermatozoa in late apoptosis, with altered chromatin compactness, or DNA fragmentation already after 3 hours of incubation. These effects were observed at a concentration similar (100 nglml) to that found in the seminal plasma of smokers (70 ng/ml), with the exception of the effects on sperm DNA fragmentation whose significant effect was detected also at a lower concentration (10 ng/ml), Nicotine may be regarded as a noxious component of cigarette smoke on the male reproductive function.Cigarette smoking is a risk factor for the onset of male sexual and reproductive diseases even today despite this topic bring highly controversial. In particular, it seems to alter sperm function though the mechanism(s) are still not entirely clear. Indeed, the combustion of tobacco releases more than 4,000 chemicals; some of them in the gaseous phase (carbon monoxide, nitric oxide, ammonia, hydrocarbons, etc.), others, such as nicotine, in the particulate phase.Nicotine is an alkaloid, and in nature is found in a non-ionized form (lipophilic) in an alkaline environment and in an ionized form (hydrophilic) in an acid environment. Under physiological conditions (pH 7.3-7.5) because of its lipophilic form (31%), nicotine crosses the biological membranes and is absorbed by the mucous membranes and skin and more than 80% is metabolized in the liver, kidney, and lung. CYP2A6 is the main cytochrome involved in its metabolism and thus in its oxidation. Nicotine concentration in the saliva of a subject, who has just finished smoking a cigarette, is about 1.56 mg/ml, 100,000 times higher than concentration in the peripheral blood, while the concentration of nicotine absorbed is about 1 mg/cigarette. From the bloodstream, nicotine and its metabolites go into

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Does alcohol have any effect on male reproductive function? A review of literature

Cited by 148 publications

References 34 publications

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Substance Use and Preconception Care: A Review of the Literature

In Vitro Effects of Nicotine on Sperm Motility and Bio-Functional Flow Cytometry Sperm Parameters

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