Does Antineoplasm Treatment Decrease the Glomerular Filtration Rate in Children?

Abstract

Background: The aim of this cross-sectional study was to test the hypothesis that children diagnosed with nephroblastoma experience increased disturbance in renal filtration even after prompt treatment compared to patients treated for other neoplastic childhood diseases. Procedures: Our study included 127 children and young adults, who were successfully treated for nephroblastoma (n = 34), oncohaematological childhood diseases (n = 58), and other solid tumours (n = 35). In each patient, serum levels of cystatin C, microalbuminuria, and C-reactive protein, and serum and urine levels of creatinine were examined, along with a urine analysis. The estimated glomerular filtration rate (eGFR) was assessed using the Schwartz formula and Filler’s formula. Results: Our studies show that patients who were successfully treated for nephroblastoma and other solid tumours have lower GFR (GFR_Sch 118 ± 20, p = 0.00006, and 117 ± 22, p = 0.00003; GFR_Filler 99 ± 17, p = 0.0001, and 104 ± 21 ml/min/1.73 m², p = 0.0002) than children treated for oncohaematological diseases (GFR_Sch 137 ± 19, GFR_Filler 121 ± 18 ml/min/1.73 m²). Conclusions: Patients diagnosed with nephroblastoma and other solid tumours have lower eGFR than children with oncohaematological childhood diseases and are at higher risk for developing CKD. This study demonstrates the necessity of nephrological monitoring.

Serum levels of salusin β in acute lymphoblastic leukaemia and Wilms’ tumour survivors – preliminary report

“…Such results were confirmed by previous studies. Poor renal function in WTs was also observed in our previous studies [25,26].…”

Serum level of salusin β as an indicator of metabolic disorders in Acute Lymphoblastic Leucaemia and Wilms Tumour survivors

“…The explanation for this may be associated with the worse renal function expressed by the higher levels of cystatin c and lower cystatin-based eGFR in the WTs than in the ALLs. Poor renal function in WTs was also observed in our previous studies (21) (22). Research performed by Kołakowska et al revealed a higher level of serum salusin β among patients with hypertension than in the reference group (the subjects diagnosed with white-coat hypertension).…”

Screening of renal dysfunction among Burkitt lymphoma survivors by novel markers

“…Cystatin-C has been proved to be superior to s.cr as marker of kidney filtration function as it is not influenced by non-renal factors such as muscle mass, diet, and drugs, and is independent of age, sex, weight, and bilirubin level [15,16,34]. It is a good screening for reduced GFR in children with neoplastic diseases [9,35] and in pediatric kidney, liver, and heart transplant recipients [11,[36][37][38][39]. Lankisch and colleague documented the diagnostic value of s.Cys-C especially among young (<3 years) cancer survivors, they described s.Cys-C as hopeful accurate modality for renal function monitoring in these at-risk patients [9].…”