Background: The aim of this cross-sectional study was to test the hypothesis that children diagnosed with nephroblastoma experience increased disturbance in renal filtration even after prompt treatment compared to patients treated for other neoplastic childhood diseases. Procedures: Our study included 127 children and young adults, who were successfully treated for nephroblastoma (n = 34), oncohaematological childhood diseases (n = 58), and other solid tumours (n = 35). In each patient, serum levels of cystatin C, microalbuminuria, and C-reactive protein, and serum and urine levels of creatinine were examined, along with a urine analysis. The estimated glomerular filtration rate (eGFR) was assessed using the Schwartz formula and Filler’s formula. Results: Our studies show that patients who were successfully treated for nephroblastoma and other solid tumours have lower GFR (GFR_Sch 118 ± 20, p = 0.00006, and 117 ± 22, p = 0.00003; GFR_Filler 99 ± 17, p = 0.0001, and 104 ± 21 ml/min/1.73 m², p = 0.0002) than children treated for oncohaematological diseases (GFR_Sch 137 ± 19, GFR_Filler 121 ± 18 ml/min/1.73 m²). Conclusions: Patients diagnosed with nephroblastoma and other solid tumours have lower eGFR than children with oncohaematological childhood diseases and are at higher risk for developing CKD. This study demonstrates the necessity of nephrological monitoring.

CysC levels may be elevated in people with normal GFR. Hypertrophy of a single kidney increases with deteriorating kidney function. PT/KL should be verified in future studies as a sonographic marker of kidney impairment.

STS in NF1 seem to display poor prognosis in spite of combined therapy; thus, children with NF1 should remain under detailed control of the oncologist.

PS-011 Figure 1Poster symposium Arch Dis Child 2014;99(Suppl 2):A1-A620 A115

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