Does anxiety underly imidazole-induced behavioural effects in the rat?

Ferrari, Francesca; Tartoni, Pier Luigi; Monti, Alessio; Mangiafico, V.

doi:10.1007/bf00445555

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…However, as opposed to aggression and impulsivity, irritability – in humans – is not just behaviorally defined, but involves subjective state changes (147); therefore, the modeling of irritability in rodents is conceptually complicated. A variety of drugs such as parachlorophenylalanine (148) and trimethyltin (149), and imidazole (150) can provoke this state. Likewise, psychoactive drug withdrawal, especially for opiate drugs, reportedly most robustly elicits this state (151, 152).…”

Section: Post Injury Symptoms In Animal Models Of Tbimentioning

confidence: 99%

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Malkesman¹,

Tucker²,

Ozl³

et al. 2013

Front. Neurol.

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Each year in the US, ∼1.5 million people sustain a traumatic brain injury (TBI). Victims of TBI can suffer from chronic post-TBI symptoms, such as sensory and motor deficits, cognitive impairments including problems with memory, learning, and attention, and neuropsychiatric symptoms such as depression, anxiety, irritability, aggression, and suicidal rumination. Although partially associated with the site and severity of injury, the biological mechanisms associated with many of these symptoms – and why some patients experience differing assortments of persistent maladies – are largely unknown. The use of animal models is a promising strategy for elucidation of the mechanisms of impairment and treatment, and learning, memory, sensory, and motor tests have widespread utility in rodent models of TBI and psychopharmacology. Comparatively, behavioral tests for the evaluation of neuropsychiatric symptomatology are rarely employed in animal models of TBI and, as determined in this review, the results have been inconsistent. Animal behavioral studies contribute to the understanding of the biological mechanisms by which TBI is associated with neurobehavioral symptoms and offer a powerful means for pre-clinical treatment validation. Therefore, further exploration of the utility of animal behavioral tests for the study of injury mechanisms and therapeutic strategies for the alleviation of emotional symptoms are relevant and essential.

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Section: Post Injury Symptoms In Animal Models Of Tbimentioning

confidence: 99%

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Malkesman¹,

Tucker²,

Ozl³

et al. 2013

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Several paradigms are used to measure irritability in laboratory animals (see Table 1, Figure 3), and a variety of drugs can induce irritability in rodents including para-chlorophenylalanine (PCPA) [50], trimethyltin [51], midazole [51], etc. However, irritable behavior in rodents appears to occur most robustly and frequently during periods of psychoactive drug withdrawal, especially for opiate drugs [52, 53].…”

Section: Introductionmentioning

confidence: 99%

Animal models of suicide-trait-related behaviors

Malkesman

Pine

Tragon

et al. 2009

Trends in Pharmacological Sciences

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Although antidepressants are at least moderately effective in treating major depressive disorder (MDD), concerns have arisen that selective serotonin reuptake inhibitors (SSRIs) are associated with suicidal thinking and behavior, especially in children, adolescents, and young adults. Virtually no experimental research in model systems has considered the mechanisms by which SSRIs may be associated with this potential side effect in some susceptible individuals. Suicide is a complex behavior that is, at best, complicated to study in humans and impossible to fully reproduce in an animal model. However, by investigating traits that show strong cross-species parallels as well as associations with suicide in humans, animal models may elucidate the mechanisms by which SSRIs are associated with suicidal thinking and behavior in the young. Traits linked with suicide in humans that can be successfully modeled in rodents include aggression, impulsivity, irritability, and hopelessness/helplessness. Differences in animal response to particular paradigms and to SSRIs across the lifespan are also discussed. Modeling these relevant traits in animals can help clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population.

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Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against α2-adrenoceptor mediation

et al. 1995

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The influence of alpha 2-adrenoceptor antagonists in animal models of anxiety is quite inconsistent, with results spanning the full range of effect from anxiogenesis to anxiolysis. In the present study, an ethological technique was used to examine the effects of yohimbine (0.5-4.0 mg/kg) on plus-maze behaviour in DBA/2 mice. Results indicated significant anxiolytic-like effects on standard spatiotemporal measures at 2.0-4.0 mg/kg, and on risk assessment measures across the entire dose range. Full-scale follow-up studies with T1 and BALB/c strains confirmed that this action of yohimbine in the murine plus-maze is not peculiar to DBA/2 mice. The more selective alpha 2-adrenoceptor antagonist, idazoxan (0.63-5.0 mg/kg), exerted much weaker behavioural effects in the maze while the alpha 2-adrenoceptor agonist, clonidine (0.01-0.1 mg/kg), produced a profile consistent with non-specific behavioural disruption. Data are discussed in relation to the possible involvement of 5-HT1A receptor mechanisms in the observed anxiolytic-like effects of yohimbine in the murine plus-maze.

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Does anxiety underly imidazole-induced behavioural effects in the rat?

Cited by 7 publications

References 33 publications

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Animal models of suicide-trait-related behaviors

Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against α2-adrenoceptor mediation

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