Does atopy affect the course of viral pneumonia?

Erdem, Semiha Bahçeci; Can, Demet; Girit, Saniye; Çatal, Ferhat; Şen, Velat; Pekcan, Sevgi; Yüksel, Hasan; Bingöl, Ayşe; Bostancı, İlknur; Erge, Duygu; Ersu, Refika

doi:10.1016/j.aller.2017.04.003

Cited by 6 publications

(9 citation statements)

References 40 publications

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“…On the other hand, it is also worth thinking whether allergic diseases could affect respiratory virus infections. A multicenter prospective study examined the effects of the presence of atopy, which was defined as positive skin prick tests to one or more allergens, on the course of disease in children hospitalized with viral pneumonia. In that study, atopy was found in 21.4% patients, while it showed there was no effect of atopic sensitization on the severity of viral pneumonia in children.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Zhang

Dong

Cao

et al. 2020

Allergy

3,570

318

3,180

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Background: Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. Methods:Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed.Results: An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were communityacquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients.Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001). Conclusion:Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Zhang

Dong

Cao

et al. 2020

Allergy

3,570

318

3,180

View full text Add to dashboard Cite

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“…An association between childhood pneumonia and asthma has been noticed for long (29–31). Parental asthma, earlier wheezing, and exposure to tobacco smoke are associated with more severe clinical course of pneumonia (32). In our study, asthma was slightly more common in RV-positive patients than others, but, contrary to our expectation, wheezing in auscultation of lungs was not more prevalent among RV-positive than RV-negative CAP patients.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Hospitalized Rhinovirus-Associated Community-Acquired Pneumonia in Children, Finland, 2003–2014

et al. 2019

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Background: Rhinovirus (RV) is the most common cause of respiratory tract infections in children but, still, the clinical characteristics of RV-associated pneumonia have not been sufficiently investigated.Methods: We identified children and adolescents younger than 18 years of age treated for community-acquired pneumonia as inpatients at the Turku University Hospital from 2003 to 2014 and analyzed for RV by PCR of a respiratory tract specimen. We collected the data from medical records and compared RV-positive children with RV-negative children.Results: Of the study population of 313 children with pneumonia who were studied for RV, it was detected in 82 (26%). RV-positive children were younger (median age 2.6 years, interquartile range [IQR] 1.1–4.6 vs. 3.5 years, IQR 1.7–8.3, p = 0.002) and they had more often a history of preterm birth (16% vs. 5%, adjusted odds ratio 2.89, 95% confidence interval 1.21–6.92, p = 0.017) than RV-negative children. RV-positive children had a higher median white blood cell count than RV-negative children at presentation with pneumonia. The signs, symptoms, and severity of pneumonia were mostly similar in RV-positive and RV-negative children.Conclusions: RV was frequently detected in young children hospitalized with community-acquired pneumonia. We identified premature birth as a factor associated with RV-positive pneumonia. The clinical features of pneumonia did not clearly differ between RV-positive and RV-negative children. Further studies are needed to clarify the clinical significance of detection of RV in children with pneumonia.

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“…20 On the other hand, atopic sensitization had no effect on the severity of viral pneumonia in children, as shown in a multi-center prospective study, but the history of allergic diseases such as atopic dermatitis, food allergy and drug allergy were associated with severe pneumonia. 21 In a previous study on 140 adult COVID-19 cases, allergic diseases and asthma showed much less prevalence compared to population levels, suggesting that allergy is not a predisposing factor for SARS-CoV-2 infection. 22 This study aims to investigate the clinical and laboratory characteristics of hospitalized COVID-19 pediatric patients, and to reveal the relationship between SARS-CoV-2 infection, immune response and allergic status, with a special focus on disease severity and allergy in patients.…”

Section: Introductionmentioning

confidence: 91%

Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status

Zhang

Cao

et al. 2020

Preprint

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The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has made widespread impact recently. We aim to investigate the clinical characteristics of COVID-19 children with different severities and allergic status. Pediatric COVID-19 patients tended to have a mild clinical course. Patients with pneumonia had higher proportion of fever and cough and increased inflammatory biomarkers than those without pneumonia. There was no difference between allergic and non-allergic COVID-19 children in aspects of incidence, clinical features, laboratory and immunological findings. Allergy was not a risk factor for developing and severity of SARS-CoV-2 infection and hardly influenced the disease course of COVID-19 in children.

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Does atopy affect the course of viral pneumonia?

Abstract: When patients with mild-moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children.

Cited by 6 publications

References 40 publications

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Characteristics of Hospitalized Rhinovirus-Associated Community-Acquired Pneumonia in Children, Finland, 2003–2014

Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status

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