Does baseline Hp status impact erosive esophagitis (EE) healing rates?

Vakil, Nimish B.; Kahrilas, PJ; Magner, David J.; Skammer, Wendy; Levine, Jeremiah

doi:10.1016/s0002-9270(00)01246-6

Cited by 4 publications

(5 citation statements)

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“…A lack of significant differences in endoscopic healing between the two groups using different PPIs has also been reported in the literature (33)(34)(35). On the other hand, some other studies have postulated a higher healing rate associated with the presence of HP when treating patients with pantoprazole (31,32).…”

Section: Discussionmentioning

confidence: 78%

“…There have been some investigations with different PPIs such as omeprazole, pan- toprazole, lansoprazole, and esomeprazole reporting no differences in terms of symptom relief and/or endoscopic healing regarding HP status (33,34,43,44). Nevertheless, we should point out that many of these studies have been published as abstracts.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are some studies that have failed to demonstrate such an effect using different PPIs such as omeprazole, esomeprazole, and lansoprazole (33)(34)(35).…”

mentioning

confidence: 99%

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Helicobacter pylori Infection in Patients with Erosive Esophagitis Is Associated with Rapid Heartburn Relief and Lack of Relapse After Treatment with Pantoprazole

Calleja¹,

Suarez

Tejada³

et al. 2005

Dig Dis Sci

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Previous studies have shown an increased effect of proton pump inhibitors on intragastric pH in Helicobacter pylori (HP)-infected patients suffering from gastroesophageal reflux disease (GERD). We evaluated the effect of HP infection on healing and symptom relief in GERD patients with erosive esophagitis treated with pantoprazole. Two hundred twenty-seven patients with endoscopically proven reflux esophagitis were treated for 8 weeks with pantoprazole, 40 mg daily. Patients achieving endoscopic healing at that time were treated for 16 weeks more with pantoprazole, 20 mg daily. Healing and symptom relief rates for HP infection were compared. We found complete relief of heartburn in 72.3% of the HP-positive versus 58.8% of the HP-negative group (P < 0.05). Overall prevalence of heartburn at 8 weeks was higher in the HP-negative group (40.3 vs. 25.8%; P < 0.05), with no significant differences in endoscopic healing (overall 80.4%). At 24 weeks of treatment, the symptomatic relapse rate was higher in the HP-negative group (25.9 vs. 10.2%; P < 0.020). At 8 weeks, patients with erosive esophagitis and HP infection exhibited a significantly better response to pantoprazole through complete heartburn relief, with no differences in endoscopic healing rates between the groups. After 24 weeks, the relapse rate was significantly higher in the HP-negative group.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori Infection in Patients with Erosive Esophagitis Is Associated with Rapid Heartburn Relief and Lack of Relapse After Treatment with Pantoprazole

Calleja¹,

Suarez

Tejada³

et al. 2005

Dig Dis Sci

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“…It would be reasonable to assume that such an effect would also be observed among esomeprazole‐treated individuals and that this would result in higher healing rates for H. pylori ‐positive EE patients treated with esomeprazole. However, in a post‐hoc analysis of randomized controlled trials to evaluate the effects of H. pylori on healing of EE by esomeprazole, no effect was found of H. pylori status on healing rates with esomeprazole treatment 23 …”

Section: Discussionmentioning

confidence: 96%

A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study

Labenz

Armstrong

Lauritsen

et al. 2005

Aliment Pharmacol Ther

142

113

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SUMMARYAim: To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study. Methods: Patients had a history of gastro-oesophageal reflux disease symptoms ( ‡6 months) and had suffered heartburn on at least 4 of the 7 days preceding enrolment. Endoscopies were performed to grade EE severity using the Los Angeles (LA) classification system at baseline, 4 and 8 weeks (if unhealed at 4 weeks). Heartburn severity was recorded by patients on diary cards. The primary end point was healing of EE by week 8 of treatment.Results: Of 3170 patients randomized, the intentto-treat population consisted of 3151 patients (63% male, mean age: 50.6 years, 27% Helicobacter pyloripositive). Esomeprazole 40 mg healed a significantly greater proportion of EE patients than pantoprazole 40 mg at both 4 weeks (life table estimates: esomeprazole 81%, pantoprazole 75%, P < 0.001) and 8 weeks (life table estimates: esomeprazole 96%, pantoprazole 92%, P < 0.001). The median time to reach sustained heartburn resolution was 6 days in patients receiving esomeprazole and 8 days with pantoprazole (P < 0.001). Conclusion: Esomeprazole 40 mg is more effective than pantoprazole 40 mg for healing EE and providing resolution of associated heartburn.

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“…Several other studies also showed no difference in H. pylori-positive and H. pylori-negative subjects in terms healing of reflux oesophagitis with esomeprazole. 14,38 Similarly, H. pylori status had no significant effect on the rate of healing provided by esomeprazole 40 mg q.d. in our study.…”

Section: Discussionmentioning

confidence: 97%

Esomeprazole in acute and maintenance treatment of reflux oesophagitis: a multicentre prospective study

et al. 2008

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Does baseline Hp status impact erosive esophagitis (EE) healing rates?

Cited by 4 publications

References 0 publications

Helicobacter pylori Infection in Patients with Erosive Esophagitis Is Associated with Rapid Heartburn Relief and Lack of Relapse After Treatment with Pantoprazole

Helicobacter pylori Infection in Patients with Erosive Esophagitis Is Associated with Rapid Heartburn Relief and Lack of Relapse After Treatment with Pantoprazole

A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study

Esomeprazole in acute and maintenance treatment of reflux oesophagitis: a multicentre prospective study

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