Does body height reduction influence interpretation of lung function in COPD patients?

Kjensli, A.; Ryg, Morten; Falch, Jan A.; Armbrecht, Gabriele; Diep, Lien My; Eriksen, Erik Fink; Ellingsen, Ivar

doi:10.1183/09031936.00148609

Cited by 13 publications

(8 citation statements)

References 24 publications

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“…The number of subjects both in the COPD and control groups is low however it was possible to demonstrate the impact of height loss across the cohort. Furthermore, historical heights were measured by the clinical staff in their local clinical settings in contrast to the work of Kjensli and colleagues [21]. Kjensli and colleagues reviewed whether height reduction influences interpretation of lung function in COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Precision in Diagnosing and Classifying COPD: Comparison of Historical Height with Current Height and Arm Span to Predict FEV1

Ansari

Keaney²,

Price³

et al. 2012

TORMJ

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Background: Measured reductions in lung function, as a result of COPD, use a measured current value and make comparisons to a determined ‘normal’ value arrived at using a regression equation based upon a patients height. Osteoporosis is a recognised co-morbidity in patients with chronic obstructive pulmonary disease (COPD) and may cause excessive height loss resulting in the ‘normal’ values and disease progression being under-estimated.Purpose: The aim of the study was to examine the height variation in a cohort of COPD patients and controls over a 7-8 years period and evaluate its impact on estimates of lung function and hence COPD progression.Methods: In 1999-2002 we studied a cohort of primary care patients in Sunderland, UK with and without COPD and reexamined 104 (56 male) during 2007-2009. We calculated FEV1% predicted for actual and estimated height (armspan/1.03 and armspan/1.01 in males and females respectively).Results: In 1999-2002 the subjects were aged 62.6 ± 9.4 years, BMI was 26.4± 4.7 kg/m2, predicted FEV1 was 59.0 ±16.0, and mean actual height was 167.3±8.9cm. The actual height changed significantly (p<0.001) by 2cms over time in both genders. Whilst the overall classifications of the cohort did not change significantly when armspan was used to determine height and hence normal lung volume, individual cases did move to a classification of higher severity.Conclusions: The study suggests that current measured height may underestimate the degree of impairment of FEV1 and hence progression of COPD. The use of height, derived from armspan, may give a more accurate measure of ‘normal’ lung volumes and hence the degree of impairment.

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Section: Discussionmentioning

confidence: 99%

Precision in Diagnosing and Classifying COPD: Comparison of Historical Height with Current Height and Arm Span to Predict FEV1

Ansari

Keaney²,

Price³

et al. 2012

TORMJ

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“…Larger than normal height reduction, frequently presented in subjects with vertebral fracture, may overestimate lung function (in % of predicted) with adjustments for current height instead of previous height or arm-span [28]. We therefore performed analyses based on previous height measures from 14 years earlier in a subsample of the population, but we still found no associations between pulmonary function and vertebral fracture, as opposed to the associations found by Leech et al [14] and Schlaich et al [17].…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional associations between prevalent vertebral fracture and pulmonary function in the sixth Tromsø study

et al. 2013

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BackgroundPersons with vertebral fracture may have reduced pulmonary function, but this association has not been much studied. The aim of this cross-sectional study was therefore to examine the relationship between vertebral fracture and pulmonary function in a general, elderly population.MethodsVertebral morphometry was used for vertebral fracture assessment in 2132 elderly men (n = 892) and women (n = 1240) aged 55 to 87 years in the population-based Tromsø Study 2007–08. Pulmonary function was examined by spirometry. Pulmonary function was expressed as FVC% predicted, FEV1% predicted, and FEV1/FVC% predicted values, adjusted FVC, FEV1, and FEV1/FVC, and obstructive and restrictive ventilatory impairment. Vertebral fracture was classified according to appearance, number, severity, and location of fractures. Associations were analyzed using general linear and logistic models.ResultsFVC% predicted and FEV1% predicted values were not associated with vertebral fracture (P > 0.05), whereas FEV1/FVC% predicted ratio was associated with both prevalent fracture, number of fractures, severity of fractures, and fracture site in men (P < 0.05), but not in women. When FVC, FEV1, and FEV1/FVC values were adjusted for multiple covariates, we found no significant association with vertebral fracture. Obstructive and restrictive ventilatory impairment was not associated with prevalent vertebral fracture.ConclusionsIn conclusion, this study did not confirm any clinically relevant associations between prevalent vertebral fracture and ventilatory impairment in elderly individuals.

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“…Regarding body height, several studies have provided evidence that a decrease in body height over time can reflect osteoporosis and other diseases, such as impaired lung function [44,45]. Therefore, we intend to investigate the relationship between decreases in body height and various diseases or disorders.…”

Section: Obesity Underweight and Malnutritionmentioning

confidence: 99%

Design of the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS): A Multidisciplinary Observational Epidemiological Study

Muneyuki¹,

Suwa²,

Oshida³

et al. 2013

OJEMD

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Background:In the past few decades, the incidence of cardiometabolic diseases and disorders of the liver, kidney, pancreas, heart, and lung, have been increasing in Western and Asian countries, including Japan. Numerous factors, including abnormal body weight (obesity, overweight, or underweight), infrequent exercise, and other unfavorable lifestyle factors (e.g., smoking and heavy alcohol drinking) have been proposed as risk factors for the development and the progression of diseases, such as type 2 diabetes, hypertension, and dyslipidemia, which ultimately lead to impaired organ function and possibly death. However, the mechanisms that link these risk factors with diseases are still poorly understood, and the potential treatments, including pharmacotherapy and diet, have not been fully evaluated. Methods: In 2011, we established a new collaborative research program, the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS). This multidisciplinary observational epidemiological research study was designed to cover several high-profile diseases and some traditional fields of internal medicine, as well as apparently unrelated fields and particular lifestyle factors, such as unhealthy eating behaviors. In a series of studies, apparently healthy subjects who underwent a regular medical checkup were retrospectively identified based on the results of their medical checkups. In this way, the incidence, prevalence, causality, and clinical relevance of specific conditions and diseases have been investigated in cross-sectional analyses of 100,000 -200,000 adults, and in longitudinal studies of several thousand subjects who underwent medical checkups multiple times. Discussion: This article describes the background, rationale, purpose, and methods of the SCDOIS. Using data obtained from annual medical checkups, our goals are to 1) establish criteria or identify clinical features that would enable clinicians to detect the presence of abnormal conditions associated with cardiometabolic diseases and/or organ impairment much earlier in the disease course; and 2) determine the potential mechanisms and therapies for these conditions.

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Does body height reduction influence interpretation of lung function in COPD patients?

Cited by 13 publications

References 24 publications

Precision in Diagnosing and Classifying COPD: Comparison of Historical Height with Current Height and Arm Span to Predict FEV1

Precision in Diagnosing and Classifying COPD: Comparison of Historical Height with Current Height and Arm Span to Predict FEV1

Cross-sectional associations between prevalent vertebral fracture and pulmonary function in the sixth Tromsø study

Design of the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS): A Multidisciplinary Observational Epidemiological Study

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