Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity?

Peixoto-Silva, Nayara; Conceição, Ellen Paula Santos da; Carvalho, Janaíne Cavalcanti; Lima, Natália S.; Nogueira-Neto, José Firmino; Oliveira, Elaine de; Moura, Egberto Gaspar de; Lisboa, Patrícia Cristina

doi:10.1016/j.lfs.2013.12.013

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…At adulthood, we observed higher visceral fat mass, hyperinsulinemia, increase of blood glucose and triglycerides, leptin resistance, hypothyroidism, hypoprolactinemia, increased catecholamine adrenal content and serum corticosterone Moura et al, 2009). Also, we found higher neuropeptide Y (NPY) and lower cocaine-and amphetamine-regulated transcript (CART) (Younes-Rapozo et al, 2012), adipocyte hypertrophy and higher liver oxidative stress (Peixoto-Silva et al, 2014), as well as higher levels of anxiety-like behavior, impaired learning and memory performance (Fraga et al, 2011). It is conceivable that the metabolic and hormonal changes previously observed when BRO was administered in lactating dams are associated with either an increase in the leptin milk transfer (Bonomo et al, 2005) or in BRO milk transfer, since it was demonstrated that, in humans, BRO can be transferred via breast milk (Kulski et al, 1978;Katz et al, 1985).…”

Section: Introductionmentioning

confidence: 72%

“…Frozen coronal brain sections were cut using a cryostat (Hyrax C25, Zeiss, Germany) and punches of the hypothalamic paraventricular nucleus (PVN; bregma 0.6 to to 2.1 mm) and the hypothalamic arcuate nucleus (ARC; bregma 2.1 to 3.6 mm) were extracted from the brains using the anatomical references indicated in the Paxinos & Watson (1998) stereotaxic coordinates atlas. The samples were maintained in liquid nitrogen and stored at −80°C for determination of protein content by Western blotting.…”

Section: Methodsmentioning

confidence: 99%

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Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

et al. 2016

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Section: Introductionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

et al. 2016

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“…Additionally, the higher triglyceride content in the liver of the NPEW offspring was improved by BRO treatment at end of lactation, suggesting a protection against hepatic fat accumulation. A previous study demonstrated that EW promotes deleterious effects in the liver as microesteatosis and increased oxidative stress 14 and that BRO transfer through breast milk is able to prevent such damage to the liver tissue. 15 Currently, we confirm that direct BRO treatment in the pups had a positive influence on the hepatic fat accumulation associated with an improvement in adiposity.…”

Section: Discussionmentioning

confidence: 99%

“…However, different hepatic responses were identified in these models because the non‐pharmacological model promotes an increase in liver triglycerides and microsteatosis, associated with increased oxidative stress . These hepatic injuries were not observed in the pharmacological model, possibly because of the transference of the BRO in the breast milk attenuating the dysfunctions in the redox state and preventing the hepatic steatosis in the offspring at adulthood …”

Section: Introductionmentioning

confidence: 99%

Bromocriptine treatment at the end of lactation prevents hyperphagia, higher visceral fat and liver triglycerides in early‐weaned rats at adulthood

Peixoto-Silva

Moura

Carvalho

et al. 2017

Clin Exp Pharma Physio

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Non-pharmacological early weaning (NPEW) leads offspring to obesity, higher liver oxidative stress and microsteatosis in adulthood. Pharmacological EW (PEW) by maternal treatment with bromocriptine (BRO) causes obesity in the adult progeny but precludes hepatic injury. To test the hypothesis that BRO prevents the deleterious changes of NPEW, we injected BRO into the pups from the NPEW model in late lactation. Lactating rats were divided into two groups: dams with an adhesive bandage around the body to prevent breastfeeding on the last 3 days of lactation and dams whose pups had free suckling (C). Offspring from both groups were subdivided into two groups: pups treated with BRO (intraperitoneal (i.p.) 4 mg/kg per day) on the last 3 days of lactation (NPEW/BRO and C/BRO) or pups treated with the vehicle (NPEW and C). At PN120, offspring were challenged with a high fat diet (HFD), and food intake was recorded after 30 minutes and 12 hours. Rats were killed at PN120 and PN200. At PN120, adipocyte size was greater in the NPEW group but was normal in the NPEW/BRO group. At PN200, the NPEW group presented hyperphagia, higher adiposity, adipocyte hypertrophy, hyperleptinaemia, glucose intolerance and increased hepatic triglycerides. These parameters were normalized in the NPEW/BRO group. In the feeding test, BRO groups showed lower HFD intake at 30 minutes than did their controls; however, at 12 hours, the NPEW group ate more HFD. The treatment with BRO can preclude some deleterious effects of the NPEW model, which prevented the development of overweight and its comorbidities.

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“…Both models of EW promote reduction of body weight and total fat at 21 days old [21,24] with late effects such as overweight, increased adiposity, hyperleptinemia, and increased vitamin D at 180 days old [19][20][21], 23]. In addition, hypertrophy of epididymal and retroperitoneal adipocytes was found [25,26]. However, only animals of NPEW model present hyperphagia [2,21], and only animals of PEW model show hypothyroidism [27,28].…”

Section: Introductionmentioning

confidence: 99%

Body Adiposity and Endocrine Profile of Female Wistar Rats of Distinct Ages that were Early Weaned

et al. 2019

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Early weaning (EW) is a risk factor for metabolic syndrome. Male rats that were precociously weaned present neonatal malnutrition and, in adulthood, developed overweight, accumulation of body fat, dyslipidemia, changes in glycemic homeostasis, hyperleptinemia, and increase of vitamin D. As metabolic profile of early-weaned females is not known, we investigated the endocrine-metabolic parameters in adolescence and adult female rats of 2 different EW models. Wistar lactating rats and pups from both sexes were separated into 3 groups: non-pharmacological EW (NPEW), dams were involved with a bandage interrupting suckling in the last 3 days of lactation; pharmacological EW (PEW), dams were bromocriptine-treated (0.5 mg/twice a day via intraperitoneal injection) for 3 days before weaning; and control, dams whose pups ate milk throughout lactation. At 21 days-old, NPEW and PEW females had lower body weight. At 180 days-old, NPEW and PEW females showed higher feed efficiency, weight gain, body fat percentage, and greater accumulation of gonadal and retroperitoneal fat depots associated with adipocyte hypertrophy. NPEW females also showed hyperphagia. Only NPEW females presented hyperleptinemia. Plasma thyroid hormones and vitamin D were unchanged among EW females. Regarding sex hormones, at 45 days-old, no change was found in EW females, while at 180 days-old, PEW females had hypoestrogenemia. EW increases the risk for obesity in female rats in adulthood, as already demonstrated for males, although through distinct mechanisms involving some hormones.

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Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity?

Cited by 14 publications

References 27 publications

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

Bromocriptine treatment at the end of lactation prevents hyperphagia, higher visceral fat and liver triglycerides in early‐weaned rats at adulthood

Body Adiposity and Endocrine Profile of Female Wistar Rats of Distinct Ages that were Early Weaned

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