Does coronal oblique length of spleen on CT reflect splenic index?

Indiran, Venkatraman; Singh, Naorem Vinod; Prasad, T. Ramachandra; Maduraimuthu, Prabakaran

doi:10.1007/s00261-017-1055-1

Cited by 19 publications

(14 citation statements)

References 23 publications

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“…In fact, ideally, splenic index calculated for the splenic volume, using the craniocaudal dimension, width, and thickness, would be the most reliable measurement for diagnosing splenomegaly. However, according to literature [18][19][20]31 , a single measurement, for example the craniocaudal length, is not different to emphasise the splenic index from the one calculated for the splenic volume.…”

Section: ■ Discussionmentioning

confidence: 99%

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

et al. 2018

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Purpose: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly. Methods: Sixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. All patients underwent abdominal ultrasound to measure the spleen. The hematological test results were compared to the size of the spleen. Results: The size of the spleen varied from 14.0 to 28.4 (19.9 ± 3.7) cm according to the ultrasound image. Thrombocytopenia was observed 58 (95%) patients, leukopenia in 55 (90%) patients, and anemia in 32 (52.4%) patients. Leukopenia was proportional to splenomegaly. Conclusion: Schistosomal splenomegaly leads to leukopenia in direct proportion to the size of the spleen.

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Section: ■ Discussionmentioning

confidence: 99%

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

et al. 2018

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“…Out of 105 patients, 85 of them underwent endoscopic evaluation for varices prior to AB treatment. To assess splenomegaly, we calculated the splenic index based on the formula (craniocaudal dimension × width × thickness) and defined patients with splenomegaly as having a splenic index > 480 (12).…”

Section: Methodsmentioning

confidence: 99%

Case Report: Exacerbation of varices following atezolizumab plus bevacizumab treatment of hepatocellular carcinoma: A case series and literature review

et al. 2022

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Recently, a combined regimen of atezolizumab and bevacizumab (AB) treatment has been approved as a first-line treatment in patients with advanced hepatocellular carcinoma (HCC), contributing to prolonged survival. However, we often encounter cases where treatment must be discontinued due to the occurrence of adverse events. One of these events, which is often fatal, is gastrointestinal bleeding. To clarify the clinical effects of gastrointestinal bleeding after AB treatment, we evaluated patients with HCC who were treated with AB at our institution. Of the 105 patients, five treated with AB developed gastrointestinal bleeding, necessitating treatment discontinuation. Additionally, we encountered two cases where exacerbation of varicose veins was observed, and AB therapy could be continued by preventive treatment of varices. In conclusion, an appropriate follow-up is required during treatment with AB to prevent possible exacerbation of varicose veins.

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“…Participants were excluded from this study if they had white blood cell (WBC) count, mean corpuscular volume, hemoglobin level, platelets count, lactic acid dehydrogenase, creatinine, aspartate aminotransferase, alanine aminotransferase, and total bilirubin levels in their blood data that are not in the normal range (Table 1). No participant had splenomegaly on CT [18]. All the participants were considered healthy without clinical suspicion of malignancy or a severe inflammatory condition based on the diagnosis by experienced physicians who performed medical interviews and physical examinations, and imaging diagnostic radiologists who diagnosed them comprehensively.…”

Section: Participant Enrollmentmentioning

confidence: 99%

“…All the patients fasted for at least 6 h before 18 F-FDG (3 MBq/kg) administration. Whole-body PET/CT scans were performed at 60-min post injection using a Biograph Horizon TrueV FDG-PET/CT system (Siemens Medical Solutions, Knoxville, TN, USA).…”

Section: Imaging Protocolmentioning

confidence: 99%

“…Whole-body 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a glucose metabolism-based imaging technique that is currently used for staging, restaging, and therapeutic evaluation of malignant tumors. PET is a diagnostic imaging modality with excellent quantitative properties and the various quantitative values that are calculated based on the standardized uptake value (SUV), which is a semi-quantitative value of FDG accumulation, are useful for distinguishing benign and malignant tumors and predicting their prognosis [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Semi-automated histogram analysis of normal bone marrow using 18F-FDG PET/CT: correlation with clinical indicators

et al. 2022

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Background 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is increasingly applied to the diagnosis of bone marrow failure such as myeloproliferative neoplasm, aplastic anemia, and myelodysplastic syndrome, as well as malignant lymphoma and multiple myeloma. However, few studies have shown a normal FDG uptake pattern. This study aimed to establish a standard of bone marrow FDG uptake by a reproducible quantitative method with fewer steps using deep learning-based organ segmentation. Methods Bone marrow PET images were obtained using segmented whole-spine and pelvic bone marrow cavity CT as mask images using a commercially available imaging workstation that implemented an automatic organ segmentation algorithm based on deep learning. The correlation between clinical indicators and quantitative PET parameters, including histogram features, was evaluated. Results A total of 98 healthy adults were analyzed. The volume of bone marrow PET extracted in men was significantly higher than that in women (p < 0.0001). Univariate and multivariate regression analyses showed that mean of standardized uptake value corrected by lean body mass (SULmean) and entropy in both men and women were inversely correlated with age (all p < 0.0001), and SULmax in women were also inversely correlated with age (p = 0.011). Conclusion A normal FDG uptake pattern was demonstrated by simplified FDG PET/CT bone marrow quantification.

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Does coronal oblique length of spleen on CT reflect splenic index?

Cited by 19 publications

References 23 publications

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

Case Report: Exacerbation of varices following atezolizumab plus bevacizumab treatment of hepatocellular carcinoma: A case series and literature review

Semi-automated histogram analysis of normal bone marrow using 18F-FDG PET/CT: correlation with clinical indicators

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