Does covid-19 impair endogenous neurogenesis?

Kumaria, Ashwin; Noah, Moronke A.; Kirkman, Matthew A.

doi:10.1016/j.jocn.2022.09.006

Cited by 7 publications

(5 citation statements)

References 120 publications

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“…Inflammation after SARS-CoV-2 infection have also been implicated in attenuating neurogenesis [ 95 , 96 ••]. It is now considered that sustentacular cells may be the main source of cytokines or may contribute among various other cellular sources [ 83 , 84 ].…”

Section: Neurogenesis Vs Immune Response In Type 2 and Non-type 2 Inf...mentioning

confidence: 99%

“…Interestingly, the authors associate this deficit with regenerative failure of dopaminergic neurons replenishment in bulbs and OE [ 102 ], which are relevant for the maintenance of olfactory function [ 103 ]. The impaired olfactory neurogenesis may prevent recovery in the subset of COVID-19 patients with persisting LoS [ 54 ••, 96 ••].…”

Section: Neurogenesis Vs Immune Response In Type 2 and Non-type 2 Inf...mentioning

confidence: 99%

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Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations

Marin,

Alobid,

López-Chacón

et al. 2024

Curr Allergy Asthma Rep

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Purpose of Review Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this review, we describe the neurobiology of olfaction and the olfactory alterations in chronic rhinosinusitis with nasal polyps (type 2 inflammation) and post-viral acute rhinosinusitis (non-type 2 inflammation), highlighting the role of immune response attenuating olfactory neurogenesis as a possibly mechanism for the loss of smell in these diseases. Recent Findings Several studies have provided relevant insights into the role of basal stem cells as direct participants in the progression of chronic inflammation identifying a functional switch away from a neuro-regenerative phenotype to one contributing to immune defense, a process that induces a deficient replacement of olfactory neurons. The interaction between olfactory stem cells and immune system might critically underlie ongoing loss of smell in type 2 and non-type 2 inflammatory upper airway diseases. Summary In this review, we describe the neurobiology of olfaction and the olfactory alterations in type 2 and non-type 2 inflammatory upper airway diseases, highlighting the role of immune response attenuating olfactory neurogenesis, as a possibly mechanism for the lack of loss of smell recovery.

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Section: Neurogenesis Vs Immune Response In Type 2 and Non-type 2 Inf...mentioning

confidence: 99%

Section: Neurogenesis Vs Immune Response In Type 2 and Non-type 2 Inf...mentioning

confidence: 99%

Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations

Marin,

Alobid,

López-Chacón

et al. 2024

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

show abstract

“…An increasing body of data indicated that SARS-CoV-2 could invade the central nervous system (CNS) and cause neurological and neuropsychiatric complications [65][66][67][68] . Patients who had Covid-19 infection were more likely to have impairment in neurogenesis [68][69][70] and cognitive decline 71 72 . However, this data's involvement with pregnant women has been limited thus far, since the safety of maternal vaccination is more worthy of attention.…”

Section: Maternal Sars-cov-2 Vaccination Increased Hippocampal Neurog...mentioning

confidence: 99%

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring through IFN-gamma and CX3CR1-dependent mechanisms

Qi,

Yao

2024

Preprint

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The worldwide Coronavirus disease 2019 (COVID-19) pandemic affects the world, and prenatal COVID-19 infection is associated with severe adverse outcomes. Thus, both for safety and immunogenicity, the COVID-19 vaccination is strongly recommended for pregnant women. Specifically, this study examines how maternal COVID-19 vaccination affects postnatal physical development, neurogenesis, and behavior in pups. We successfully detected a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody in the plasma of vaccinated dams and their pups when inactivated COVID-19 vaccine (Vero Cell) was administered at gestational day 14.5. At the age of 1 month, pups from pregnant mice receiving the SARS-CoV-2 vaccine displayed increased proliferation, neuroblasts, neuronal stem cells, and mature neurons in the dentate gyrus (DG) and enhanced working memory. Luminex multiplex assay showed that elevated levels of hippocampal cytokines/chemokines, including interferon-γ (IFN-γ) and CX3C motif chemokine ligand 1 (CX3CL1), which are crucial for neurogenesis and memory function. Mechanistically, using conditional knockout technology, we identify microglial IFN-γ receptor 1 (IFNγR1) and CX3C motif chemokine receptor 1 (CX3CR1), as crucial intercellular participants, in the neuronal developmental process via regulating microglial activation and microglial chemotaxis, respectively. We propose that maternal SARS-CoV-2 vaccination appears to enhance hippocampal neurogenesis and working memory in offspring underlying the mechanism of microglia-proliferating neuron interaction.

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“…The SARS-CoV-2 virus is known to invade the central nervous system (CNS) and cause neurological and neuropsychiatric complications [66][67][68][69] . Patients who have experienced COVID-19 infection are more likely to have impaired neurogenesis [69][70][71] and cognitive decline 72 73 . However, these data were not focused on pregnant women, which is the focus of our study.…”

Section: Maternal Sars-cov-2 Vaccination Increased Hippocampal Neurog...mentioning

confidence: 99%

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring via IFN-gamma responsive microglia

Liu,

Tang,

Zou

et al. 2024

Preprint

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In the face of severe adverse outcomes of pandemic Coronavirus disease 2019 (COVID-19) infection, vaccines proved potently immunogenic and safe in humans and are today strongly recommended in pregnancy. This study investigates, in offspring mice, the effect of maternal COVID-19 vaccination on postnatal physical development, behavior and neurogenesis. After inoculation with inactivated COVID-19 vaccine (Vero Cell) at gestational day 14.5, antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were detected in serum of both dams and pups. At one month of age, pups born to vaccinated dams, but not the offspring of non-vaccinated dams, exhibited greater working memory and more neural cell proliferation, neuroblast formation, neuronal stem cell activity and larger numbers of mature neurons within the dentate gyrus (DG). Luminex multiplex assay revealed elevated levels of hippocampal cytokines/chemokines critical to neurogenesis and memory function, namely interferon-γ [IFN-γ] and CX3C motif chemokine ligand 1 [CX3CL1]. Conditional knockout technology implicated microglial IFN-γ receptor 1 (IFNγR1) and CX3C motif chemokine receptor 1 (CX3CR1) as crucial intercellular participants in the neuronal developmental process, via regulating microglial activation and chemotaxis, respectively. We propose that, rather than posing risk for neurodevelopmental abnormalities, maternal SARS-CoV-2 vaccination transiently enhances hippocampal neurogenesis and working memory in offspring.

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Does covid-19 impair endogenous neurogenesis?

Cited by 7 publications

References 120 publications

Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations

Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring through IFN-gamma and CX3CR1-dependent mechanisms

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring via IFN-gamma responsive microglia

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