Does Dehydroepiandrosterone supplementation improve reproductive outcomes in patients with normal ovarian reserve undergoing in vitro fertilization? A systematic review and meta-analysis

Perelló, Maria Antonia; Moreno, José María Villagrán; Crespo, M.; Espinós, Juan José; Checa, Miguel Ángel

doi:10.1016/j.medre.2022.100120

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, Zhang et al (2023) reported increased clinical pregnancy rates, live birth rates, and ovarian reserve in poor ovarian response patients with DHEA supplementation [ 17 ]. Our current investigation contributes to the literature by demonstrating a significant increase in the number of retrieved oocytes, metaphase II (MII) oocytes, fertilized oocytes, day 3 embryos, and top-quality embryos at day 3 with DHEA pretreatment [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 94%

Investigation of the Effect of Dehydroepiandrosterone (DHEA) on In Vitro Fertilization (IVF) Outcomes in a Patient With Poor Ovarian Reserve: A Case Report

Rao,

More,

Shrivastava

2024

Cureus

View full text Add to dashboard Cite

This study represents a case of a 42-year-old female patient who had a history of infertility, undergoing treatment at the in vitro fertilization (IVF) centre in Sawangi, India. The patient presented with a medical history marked by recurrent medical termination of pregnancies, a small uterus diagnosed through metroplasty, and a significant impediment to fertility treatment attributed to poor ovarian reserve. Clinical assessment revealed the male partner's history of alcohol consumption and cigarette smoking, along with benazepril usage for hypertension (5 mg/day). Despite normal semen parameters, intrauterine insemination (IUI) proved unsuccessful, prompting a recommendation for IVF utilizing the intracytoplasmic sperm injection (ICSI) procedure. The patient displayed low anti-Mullerian hormone (AMH) levels, indicative of insufficient ovarian reserve. Dehydroepiandrosterone (DHEA) supplementation was advised orally for a period of one month to enhance ovarian function. Subsequent evaluation demonstrated a notable increase in AMH levels, facilitating the retrieval of six oocytes, comprising average-quality metaphase II (MII) oocytes and one dysmorphic metaphase I (MI) oocyte. Following ICSI, successful fresh embryo transfer ensued, resulting in a positive beta-human chorionic gonadotropin (β-hCG) test with serum β-hCG levels measuring 1676 mIU/mL, confirming the successful implantation of one of the two transplanted embryos. This case underscores the significance of DHEA supplementation in augmenting ovarian reserve and achieving favorable IVF-ICSI outcomes in patients with primary infertility. The holistic approach, encompassing lifestyle modifications and tailored medication, contributed to a positive pregnancy outcome. Further research is warranted to explore the broader implications of DHEA therapy in the management of infertility.

show abstract

Section: Discussionmentioning

confidence: 94%

Investigation of the Effect of Dehydroepiandrosterone (DHEA) on In Vitro Fertilization (IVF) Outcomes in a Patient With Poor Ovarian Reserve: A Case Report

Rao,

More,

Shrivastava

2024

Cureus

View full text Add to dashboard Cite

show abstract

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction

Naik,

Lepine,

Nagels

et al. 2024

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Application of the ARAS Method in Risk Assessment and Mitigation in IVF Procedures

Ramos Velastegui,

Guato Canchinia,

Maldonado Mariño

2023

Salud, Ciencia y Tecnología - Serie de Conferencias

View full text Add to dashboard Cite

In vitro fertilization (IVF) is an assisted reproduction technique that has enabled many couples to achieve parenthood. Despite its benefits, IVF treatments carry risks and complications that can impact the mother's health and the success of the pregnancy, making a systematic evaluation of safety essential. This study applies the ARAS method to identify and mitigate the main risks associated with IVF, using criteria such as severity, frequency, impact on pregnancy, and recoverability. Among these, implantation failures and spontaneous abortions were identified as the most significant risks, followed by ovarian hyperstimulation syndrome (OHSS). To reduce these risks, an improvement and monitoring plan for IVF treatments is proposed, focused on optimizing safety and effectiveness. It includes advanced monitoring, continuous training, and regular evaluations to adapt practices to the latest research and technologies. Furthermore, the findings suggest that a personalized and evidence-based approach can significantly increase the safety of IVF treatments. Additionally, the importance of considering both medical and psychosocial factors to enhance patient experience and outcomes is emphasized. In conclusion, this study provides a solid foundation for future improvements in IVF practices, ensuring that procedures are performed in the safest and most effective manner possible

show abstract

Does Dehydroepiandrosterone supplementation improve reproductive outcomes in patients with normal ovarian reserve undergoing in vitro fertilization? A systematic review and meta-analysis

Cited by 3 publications

References 15 publications

Investigation of the Effect of Dehydroepiandrosterone (DHEA) on In Vitro Fertilization (IVF) Outcomes in a Patient With Poor Ovarian Reserve: A Case Report

Investigation of the Effect of Dehydroepiandrosterone (DHEA) on In Vitro Fertilization (IVF) Outcomes in a Patient With Poor Ovarian Reserve: A Case Report

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction

Application of the ARAS Method in Risk Assessment and Mitigation in IVF Procedures

Contact Info

Product

Resources

About