Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression

Hastings, Caitlin; Sheridan, Hannah; Pariante, Carmine M.; Mondelli, Valeria

doi:10.1007/7854_2016_31

Cited by 10 publications

(11 citation statements)

References 107 publications

(112 reference statements)

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“…With diet as a modifiable factor, limiting pro-inflammatory diets and/or favouring anti-inflammatory diets may be an approach for preventing depression and reducing depressive symptoms. For example, dietary supplementation with PUFA could improve inflammation-associated depressive symptoms ( 34 ) . In addition, nutritional interventions targeting the gut microbiota also could modulate depression ( 35 ) .…”

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and depression: a meta-analysis

Wang

Zhou

Chen

et al. 2018

Public Health Nutr.

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ObjectiveThe purpose of the present meta-analysis was to evaluate the association between the inflammatory potential of diet, determined by the dietary inflammatory index (DII®) score, and depression.DesignSystematic review and meta-analysis.SettingA comprehensive literature search was conducted in PubMed, Web of Science and EMBASE databases up to August 2018. All observational studies that examined the association of the DII score with depression/depressive symptoms were included.SubjectsFour prospective cohorts and two cross-sectional studies enrolling a total of 49 584 subjects.ResultsOverall, individuals in the highest DII v. the lowest DII category had a 23 % higher risk of depression (risk ratio (RR)=1·23; 95 % CI 1·12, 1·35). When stratified by study design, the pooled RR was 1·25 (95 % CI 1·12, 1·40) for the prospective cohort studies and 1·16 (95 % CI 0·96, 1·41) for the cross-sectional studies. Gender-specific analysis showed that this association was observed in women (RR=1·25; 95 % CI 1·09, 1·42) but was not statistically significant in men (RR=1·15; 95 % CI 0·83, 1·59).ConclusionsThe meta-analysis suggests that pro-inflammatory diet estimated by a higher DII score is independently associated with an increased risk of depression, particularly in women. However, more well-designed studies are needed to evaluate whether an anti-inflammatory diet can reduce the risk of depression.

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Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and depression: a meta-analysis

Wang

Zhou

Chen

et al. 2018

Public Health Nutr.

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“…Moreover, various inflammatory cytokines, such as TNF-α and IL-6, have been reported to be involved in the occurrence and development of ALD (27,28). Previous studies have shown that glutamine and probiotics reduce inflammation, promote the secretion of anti-inflammatory cytokines and maintain intestinal barrier functions (29,30). The present results demonstrated that probiotic and glutamine treatments reduced the abnormally elevated serum IL-6 and TNF-α levels following chronic ethanol consumption, demonstrating that probiotics and glutamine likely alleviated hepatic inflammation via the suppression of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model

et al. 2019

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The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a rat model of alcoholic liver disease (ALD). Sixty male Sprague-Dawley rats were randomly divided into 6 groups including control (C), alcohol (M), alcohol + Golden Bifido (T), alcohol + glutamine (G), alcohol + Medilac-S® (N) and alcohol + Golden Bifido + glutamine (L). Histology, body weight (BW), triglycerides (TG), serum aspartate transaminase (AST), alanine aminotransferase (ALT), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), diamine oxidase (DAO), occludin, endotoxin and D-lactate levels were assessed whilst changes in the gut flora were evaluated and compared. Results determined that all probiotic and glutamine treatments elevated the abnormally decreased BW and occludin levels whilst the abnormal elevated serum AST, ALT, TG, IL-6, TNF-α, DAO, endotoxin and D-lactate levels were significantly reduced following chronic ethanol consumption. Histopathological observation of the liver demonstrated that probiotic and glutamine treatments attenuated liver damage induced by alcohol. Moreover, sequencing determined that there was a reduction in Firmicutes as well as an increase in Actinobacteria, Proteobacteria and Porphyromonadaceae abundance in the ALD group compared with the healthy controls. However, these changes were prevented by glutamine and probiotic therapy. In conclusion, the present results suggested that probiotics and glutamine ameliorated ALD by suppressing inflammation and regulating the gut microbiota. Therefore, probiotic and glutamine treatments can potentially serve as therapies for the prevention and treatment of ALD.

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“…From a biological point of view, various hypotheses have been formulated. A healthy diet may positively affect mood by increasing brain levels of monoamines [ 42 ], reduce apoptosis of the limbic system [ 43 , 44 ], and have anti-inflammatory properties [ 45 , 46 ]. The high content of antioxidants in fruits and vegetables is likely to be protective against the negative effects of oxidative stress at neuronal level, which has been associated with depression [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and mental health after myocardial infarction

et al. 2017

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BackgroundDiet has been associated with better mental health in general populations, but less is known on this association in patients with a history of coronary heart disease.The objective of this study is to examine the cross-sectional associations between dietary patterns and mental health in elderly patients with a history of myocardial infarction.MethodsData were drawn from the final assessment of the Alpha Omega cohort that monitored patients with a history of myocardial infarction (age range 60–80 years). 2171 patients with complete data for diet and mental health were included in this study. Diet was assessed with the 203-item Food Frequency Questionnaire, and subsequently categorized into two scores: the Dutch Healthy Nutrient and Food Score (DHNaFS) and the Dutch Undesirable Nutrient and Food Score (DUNaFS). Depressive symptoms, assessed with the Geriatric Depression Scale (GDS-15), and dispositional optimism, assessed with the 4-item questionnaire (4Q), were cross-sectionally analyzed in relation to dietary patterns using linear regression analysis.ResultsPatients were on average 72.2 years old and 79.5% were male. The DHNaFS score was associated with less depressive symptoms and higher dispositional optimism (β = -0.108; P<0.001; and β = 0.074; P<0.001), whereas no associations were found with the DUNaFS score. Particularly, consumption of vegetables, fruits, whole grains, fish, and low fat-dairy were associated with less depressive symptoms and higher optimism. Similar associations were found when analyzing the association between average DHNaFS score over the preceding 41 months with depression β = -0.085; P<0.001) and higher dispositional optimism (β = 0.084; P<0.001).ConclusionsA healthy dietary pattern, in particular a higher consumption of vegetables, fruit, whole grains, fish and low-fat dairy, was associated with less depressive symptoms and higher optimism. However, given the cross-sectional nature of our analyses, our findings may also be explained by more optimistic participants making healthier food choices. Therefore, future prospective or interventions studies are needed to establish the direction of causality of this association.Trial registrationClinicalTrials.gov NCT03192410.

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Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression

Cited by 10 publications

References 107 publications

Dietary inflammatory index and depression: a meta-analysis

Dietary inflammatory index and depression: a meta-analysis

Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model

Dietary patterns and mental health after myocardial infarction

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