Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study

Abstract

Objective: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. Materials and Methods: It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche). Results: The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL; p = 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL, p = 0.41). No significant correlation between the follicular IL6 and AMH levels was observed. Conclusions: The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.

Hubungan Endometriosis Dengan Kejadian Infertilitas Di Rsud Dr. H. Abdul Moeloek Provinsi Lampung

“…Terdapat 20-25% kasus pada endometriosis mengalami tidak tepat diagnosis dan pengobatanya tertunda disebabkan frekuensi bentuk asimtomatik. Prevalensi endometriosis yang tidak diobati (30-50%) pada wanita infertilitas (Kacem-Berjeb et al, 2023).…”

Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization

“…There have been a serious of studies indicating altered concentrations of certain in ammatory factors and growth factors in the FF are associated with PCOS[8, 12,17], obesity [18], and endometriosis [19][20][21], yet few studies have explored the changes in the FF composition in women with diminished ovarian reserve.…”