Does fetuin-A mediate the association between pro-inflammatory diet and T2DM risk?

Toprak, Kadriye; Görpelioğlu, Süleyman; Özsoy, Ahmet; Özdemir, Şeyda; Ayaz, Aylin

doi:10.20960/nh.03848

Cited by 3 publications

(2 citation statements)

References 29 publications

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“… 93 In addition, a previous study suggested that a pro-inflammatory diet might aide IR and T2D development via fetuin-A. 94 Moreover, a thorough meta-analysis comprising more than 110 00 participants concluded that increased circulating levels of fetuin-A were linked to an elevated risk of T2D. 95 Serum fetuin-A levels have been proposed to be used as a potential biomarker regarding IR and PCOS.…”

Section: Insulin Resistancementioning

confidence: 99%

Insulin resistance and cardiovascular disease

et al. 2023

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Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today’s Western societies. A causal-effect relationship has been established that links IR with CVD. The mediating mechanisms are perplexing, under ongoing, rigorous investigation and remain to be fully elucidated. IR is a condition encompassing hyperglycemia and compensatory hyperinsulinemia. It occurs when insulin is not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver and adipose tissue. This alteration of insulin signaling pathways results in the development of cardiometabolic disorders, including obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction and hypertension, all of which are predisposing factors for atherosclerosis and CVD. The management of IR can be achieved through dietary modifications, the inclusion of regular exercise routines in everyday life, pharmacological agents and other interventions tailored to each individual patient’s needs. It is important to underline though that, although various antidiabetic drugs that may improve IR are available, no medications are as yet specifically approved for the treatment of IR. This narrative review will focus on the current scientific and clinical evidence pertaining to IR, the mechanisms connecting IR with CVD, as well as plausible strategies for a holistic, personalized approach for IR management.

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Section: Insulin Resistancementioning

confidence: 99%

Insulin resistance and cardiovascular disease

et al. 2023

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“…No grupo controle, além de ser notado as diferenças de aumento na avaliação antropométrica, também foi notado um aumento significativo nos marcadores inflamatórios como Fetuína-A, Interleucina-6 e Interferon-α, no qual demonstrou a ação da fetuína-A sob estas células pancreáticas. Neste estudo a inflamação causada pela alimentação pró-inflamatória do grupo controle causaram danos em níveis genéticos mediadas pela fetuína-A nas células beta, o que corresponde ao risco aumentado de desenvolver DM2 (Toprak et al, 2022).…”

Section: Fatores Genéticosunclassified

Fatores ambientais e genéticos associados no desenvolvimento de Diabetes mellitus tipo 2: revisão sistemática

Mendonça

Moura

Araújo

et al. 2022

RSD

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O Diabetes mellitus tipo 2 é a uma na qual a quantidade de insulina é incapaz de suprir a oferta de glicose, é uma das doenças que acomete pessoas no mundo. Os Fatores de desenvolvimentos das mesmas são fatores ambientais, e fatores genéticos, ambos podem ser retardados se as pessoas se submetam à um estilo de vida saudável. O objetivo principal do trabalho é buscar compreender e descrever os fatores ambientais e genéticos no DM2. Se trata de uma revisão sistemática de artigos publicados de 2012 à 2022 escritos em português, espanhol e inglês. Os critérios de exclusão foram: artigos publicados antes de 2015, que não sejam escritos em português, espanhol e inglês e que não tenham informações relativos ao DM2. Foram selecionados 19 artigos para este estudo, apenas 10 foram incluídos e 9 sustentaram os argumentos sugeridos pelos principais. Foram descritos como fatores ambientais: obesidade, hábitos alimentares ruins, sedentarismo, doenças cardiovasculares, tuberculose e hipertensão. Fatores genéticos: Polimorfismo dos genes XRCC3 T241M, XRCC1 399Gln e FTO rs3751812 e danos genéticos às células β-pancreáticas. Pode-se concluir que a base da patogênese do DMT2 são advindos de maus hábitos e sedentarismo e doenças de base, fatores que são facilmente prevenidos com mudanças na qualidade de vida, hábitos alimentares melhores e a prática de exercícios físicos. Já os demais fatores como os genéticos, a descoberta deles podem sugerir um estilo do qual venha retardar o acometimento do DMT2.

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Cardiac Hepatopathy: New Perspectives on Old Problems through a Prism of Endogenous Metabolic Regulations by Hepatokines

Berezin

Obradovic

Berezina³

et al. 2023

Antioxidants

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Cardiac hepatopathy refers to acute or chronic liver damage caused by cardiac dysfunction in the absence of any other possible causative reasons of liver injury. There is a large number of evidence of the fact that cardiac hepatopathy is associated with poor clinical outcomes in patients with acute or actually decompensated heart failure (HF). However, the currently dominated pathophysiological background does not explain a role of metabolic regulative proteins secreted by hepatocytes in progression of HF, including adverse cardiac remodeling, kidney injury, skeletal muscle dysfunction, osteopenia, sarcopenia and cardiac cachexia. The aim of this narrative review was to accumulate knowledge of hepatokines (adropin; fetuin-A, selenoprotein P, fibroblast growth factor-21, and alpha-1-microglobulin) as adaptive regulators of metabolic homeostasis in patients with HF. It is suggested that hepatokines play a crucial, causative role in inter-organ interactions and mediate tissue protective effects counteracting oxidative stress, inflammation, mitochondrial dysfunction, apoptosis and necrosis. The discriminative potencies of hepatokines for HF and damage of target organs in patients with known HF is under on-going scientific discussion and requires more investigations in the future.

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Does fetuin-A mediate the association between pro-inflammatory diet and T2DM risk?

Cited by 3 publications

References 29 publications

Insulin resistance and cardiovascular disease

Insulin resistance and cardiovascular disease

Fatores ambientais e genéticos associados no desenvolvimento de Diabetes mellitus tipo 2: revisão sistemática

Cardiac Hepatopathy: New Perspectives on Old Problems through a Prism of Endogenous Metabolic Regulations by Hepatokines

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