Does gastric acid suppression increase the risk of drug allergies?

Pickard, C.; Sampson, Anthony P.

doi:10.1111/j.1365-2222.2009.03406.x

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…The current patient was likely predisposed to Candida overgrowth by his chronic proton pump inhibitor usage [8]. Clinicians must continue to weigh the increasingly evident risks of chronic acid suppression against its protective effect on esophageal and gastric mucosa [9,10]. In the treatment of gastrocardiac fistulae, empiric coverage for Candida species should be routinely instituted until final cultures become available.…”

Section: Case Reportmentioning

confidence: 98%

Benign post-esophagectomy gastrocardiac fistula

Pentiak

Seder

Chmielewski

et al. 2011

Interactive CardioVascular and Thoracic Surgery

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The development of a gastrocardiac fistula is a rare complication following retrosternal gastric conduit creation. We report a case of a 64-year-old male who presented three years after esophagectomy with massive hematemesis. A fistulous connection between his gastric conduit and right ventricle was identified and successfully treated. Although the patient had an atypical presentation and lacked most of the commonly cited risk factors, the combination of peptic ulcer disease and Candida overgrowth resulted in the formation of a gastrocardiac fistula. Adherence to treatment principles including prompt surgical intervention, adequate coverage of the repair, and antimicrobial therapy against Candida species provides the highest likelihood of success in addressing this potentially lethal disease process.

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Section: Case Reportmentioning

confidence: 98%