Sustainability of Vietnam agriculture value chain will be dependent on various factors such as skills and experience of farmers, advanced technology, agricultural engineering, standards and models such as VIETGAP or GLOBAL GAP, etc. The role is still important, but Vietnam's agricultural production still has many Weakness points compared to other countries in the region when comparing resource use efficiency (land, water and labor). As a result, the efficiency of agricultural production tends to decrease recently. Specifically, the growth in average agricultural labor productivity annual rate of Vietnam also decreased correspondingly from 2.7% in the period 1990-1999 to 2.5% in the period 2000-2013 (World Bank, 2016). In Vietnam, we will evaluate the effectiveness of VIETGAP and GLOBAL GAP models, principles and standards applying in Vietnam agriculture value chain in a specific case study. The research results show a strict condition for applying VIETGAP and GLOBAL GAP for better quality in agriculture, including: Conditions for soil, irrigation water, fertilizers, pest control, etc. Last but not least, we also use an econometric model to measure impacts of multi macro factors on lychee price in Vietnam market over past years 2014-2019. Regression results show that we need to control inflation at low level, stable GDP growth and trade balance and exchange rate to stabilize lychee price. The research findings are of value to policy makers, farmers and investors in making decisions to invest for sustainability of Vietnam agriculture value chain. We will also make suggestions for commercial bank system in agriculture sector development.