Does Hepatic Blood Flow Decrease after Portal-Systemic Shunt?

Chauvaud, Sylvain; Grange, D; Franco, Dominique; Bismuth, H

doi:10.1159/000127685

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…Until recently, quantitative information on hepatic blood flow in the shunted rat was not available. In 1973, Chauvaud et al (2) investigated hepatic blood flow in rats, 24 h after a portacaval shunt. These authors found no significant modification in hepatic extraction efficiency of BSP nor in total hepatic blood flow after end-to-side portacaval shunt in the rat.…”

Section: Discussionmentioning

confidence: 99%

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Pector¹,

Verbeustel²,

Lambilliotte³

1975

Digestion

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Fractional clearance of colloidal gold particles (k), liver weight and hepatic cytochrome P-450 were measured in rats with portacaval shunt and in rats with portacaval shunt plus arterialization of the hepatic stump of the portal vein. The effects of enzyme induction by phenobarbital was studied in both groups. Total arterialization of the liver provides a probably normal hepatic blood flow and seems to protect the liver from post-shunt atrophy. Nevertheless, in both arterialized and shunted rats, the cytochrome P-450 concentration was significantly lower than in controls. The same results were obtained after treatment by phenobarbital. These findings suggest that normal hepatic blood flow and oxygen supply are not the main determinant of a normal activity of the hepatic microsomal bio transformation system. Substances present in portal blood would probably be necessary in maintaining hepatic cytochrome P-450 level.

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Section: Discussionmentioning

confidence: 99%

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Pector¹,

Verbeustel²,

Lambilliotte³

1975

Digestion

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“…These attempts failed to yield long surviving trans plants for the following reasons: The vascular resistance ultimately deter mined by the capillary bed forms a natural threshold for the flow pres sure. Alterations in the normal flow and intrasinusoidal pressure can at least be partially compensated, for instance by changes in the caliber of intrahepatic arteriolar sphincters [5].…”

Section: Discussionmentioning

confidence: 99%

Survival of Auxiliary Rat Liver Grafts with Decreased Portal Blood Flow

Hess¹,

Willemen²,

Jerusalem³

1978

Eur Surg Res

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After auxiliary liver transplantation in the rat, partial liver grafts (30% of the liver) were perfused with mesentericosplenic venous blood. This means a decrease in the total liver blood flow by approximately 34%. Recipient livers retained their arterial and pancreaticoduodenal inflow. Surgical interventions were carried out on the recipient’s liver to evaluate the effect of the varying iriduced functional handicap on the fate of the graft in association with a decreased liver blood flow. Graft survival was obtained in all groups, but the conditions of the graft varied inversely with the severity of the functional handicap of the recipient’s liver. Compared to previous experiments in which the auxiliary grafts were supplied with total portal blood inflow in the same experimental model, the grafts in this study showed a slightly impaired increase in weight. This impairment was attributed to the decreased blood flow. Recipient livers deteriorated or just maintained their size, even after 70% hepatectomy, despite the pancreaticoduodenal venous and arterial inflow. These results suggest that the total liver blood flow in combination with the functional state of the remaining recipient liver, rather than the quality of venous blood deriving from certain splanchnic areas and/or peculiar factor convoyed with it, determines the survival of a liver graft.

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