Does honey have any salutary effect against streptozotocin - induced diabetes in rats?

Aamri, Zakariya M. Al; Ali, Badreldin H.

doi:10.1186/s40200-016-0278-y

Cited by 10 publications

(2 citation statements)

References 30 publications

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“…The present study's results are consistent with Ahmed et al (2022), 21 who reported that feeding honeybees exacerbate blood glucose concentrations in STZ rats significantly. Al Aamri and Ali (2017) 37 conducted a study that revealed that the consumption of honeybee did not significantly impact body weight, glucose concentrations, or insulin concentrations. Abdul Sani and his colleagues (2014) 38 found that combining honeybee and ginger did not significantly impact blood glucose concentrations in STZ mice.…”

Section: Discussionmentioning

confidence: 99%

The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

Tahoon,

Eid,

Mahgoub

et al. 2023

Ind. J. Pharm. Edu. Res

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Aim: This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood glucose and cholesterol concentrations in diabetic rats when administered orally. Materials and Methods: Thirty-eight male Sprague Dawley rats were divided into normal (n=8) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided into five groups, (1) non-diabetic group (n=8) received distilled water (2 mL/ day); (2) diabetic control group (n=8) received distilled water (2 mL/ day); (3) metformin diabetic group (n=7) received 2 mL of metformin drug solution (dose=100 mg/kg/day); (4) honeybee diabetic group (n=8) received honeybee solution (dose=2 g/kg/ day); and (5) wheat germ diabetic group (n=7) received 2 mL of honeybee (95 g) mixed with wheat germ (5 g) solution (dose= 2 g/kg/day). After 28 days, blood was collected, and serum was extracted to determine glucose, HbA 1c , and blood lipids. Results: The results showed that honeybee alone and mixed with wheat germ increased blood glucose significantly above 350 mg/dL and HbA 1c above 8.4%. Conversely, the administration of wheat germ caused a noteworthy decrease in total cholesterol, triglycerides, and LDL concentrations among rats with diabetes. Conclusion: Consuming honeybees alone and combined with wheat germ may lead to hyperglycemia. Conversely, consuming honeybees in combination with wheat germ may result in hypocholesterolemia. These results indicate that honeybee and wheat germ could be functional food for managing hyperlipidemia in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

Tahoon,

Eid,

Mahgoub

et al. 2023

Ind. J. Pharm. Edu. Res

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“…Honey (Aamri & Ali, 2017 ; Erejuwa et al, 2011 ) and STZ (Aamri & Ali, 2017 ) dosages were determined based on past dose–response effects and early investigations, and distilled water dose was chosen based on a previous study (Aamri & Ali, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Intermittent fasting and exercise therapy abates STZ‐induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway

Chijiokwu

Nwangwa

Oyovwi

et al. 2022

Physiological Reports

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Diabetes is a global, costly, and growing public health issue. Intermittent fasting (IF) and exercise therapy have been shown to improve insulin sensitivity (IS) in large studies, although the underlying processes are still unknown. The goal of this study, which included both nondiabetic and diabetic rats, was to look at the mechanisms of intermittent fasting and exercise in the management of diabetotoxicity. The effects of starvation and honey on the oral glucose tolerance test, insulin tolerance test, adipocytokines, oxidative glucose metabolic enzymes, glycolytic enzymes, food intake, and body weight in rats with streptozotocin‐induced diabetes were also investigated. In the nondiabetic phase, rats were administered an oral regimen of distilled water (0.5 ml/rat), honey (1 g/kg body weight), and interventions with IF, and starvation for 4 weeks while in the diabetic phase, after STZ or citrate buffer injections, interventions with IF, exercise, starvation, and honey treatment began for 4 weeks. At all OGTT and ITT points, there was a substantial rise in glucose in the STZ group. Adipocytokines hormone, oxidative glucose metabolic enzymes, glycolytic enzymes, and body weight were all affected by STZ when compared to starvation and honey, however, IF and exercise significantly reduced these alterations. In diabetic rats, intermittent fasting and exercise enhanced serum adipocytokines levels. These findings imply that adipokines modulate glycolytic/nonmitochondrial enzymes and glucose metabolic/mitochondrial dehydrogenase to mediate the antidiabetic effects of intermittent fasting and exercise.

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Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats

Agbonifo-Chijiokwu

Nwangwa

Oyovwi

et al. 2023

J Diabetes Metab Disord

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Does honey have any salutary effect against streptozotocin - induced diabetes in rats?

Cited by 10 publications

References 30 publications

The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats

Intermittent fasting and exercise therapy abates STZ‐induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway

Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats

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