Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum?

Audeau, A.; Han, Catherine; Johnston, Michael; Whitehead, M.W.; Frizelle, Frank

doi:10.1053/ejso.2002.1304

Cited by 70 publications

(67 citation statements)

References 21 publications

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“…The relationship between human papilloma virus (HPV) and extracolonic SCC has been well reported, specifically SCC of the skin, cervix, vulva, penis, anus, oropharynx and esophagus. No evidence of HPV has been found in colonic SCC [4, 5]. …”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Colon Associated with Hypercalcemia and Hyperleukocytosis

et al. 2005

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Background/Aims: Squamous cell carcinoma of the colon is a rare entity. We report a case of a patient who presented with a perforated squamous cell carcinoma of the sigmoid colon. Results: A 45-year-old female presented with a 2-month history of worsening abdominal pain, bloody diarrhea, and vomiting. She underwent an exploratory laparotomy and was found to have keratinizing squamous cell carcinoma of the sigmoid colon that had perforated forming multiple abscess cavities. The postoperative course was complicated by hypercalcemia and persistent hyperleukocytosis, ultimately resulting in the patient’s death. Conclusions: We present the second reported case of squamous cell carcinoma of the colon associated with hypercalcemia and the first reported case of associated hyperleukocytosis.

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Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Colon Associated with Hypercalcemia and Hyperleukocytosis

et al. 2005

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“…Interrelation with the HPV infection has not been demonstrated (9) although it has been associated with another type of infections as the colitis by Entamoeba histolytica or schistosomiasis (4). According to publications and the review of the literature by Kassir et al, it appears more frequently in female form cases (66% women/34% males) and along the 5 th -6 th decade of life, as in this case (10).…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the rectum: An atypical histology

Ballestero¹,

Barnó²,

Nisa³

et al. 2016

Rev Esp Enferm Dig

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Squamous cell carcinoma of the rectum is one of the differential diagnoses of rectal tumors. It represents a low incidence in the population. The etiopathogenesis and the biology of these tumors are unclear, for this reason the gold standard treatment is difficult to establish. We present a 47-years-old woman who had a squamous cell carcinoma in medium rectum. She was treated with radiation therapy and chemotherapy and the treatment was followed by surgical excision.Key words: Rectal cancer. Rectum. Squamous cell carcinoma. Surgery. Radiotherapy. Radiochemotheraphy. INTRODUCTIONSquamous cell carcinoma of the rectum is a rarity within colorectal tumors entity. The incidence of this kind of tumors is estimated at 0.1-0.25 per 1,000 tumors (1). Due to the small number of cases of this disease, the pathogenesis is unclear and it is attributed to different assumptions about the available literature. Although surgery has been considered as the main route of approach, treatment is currently under discussion. CASE REPORTA 47-year-old woman presented with a history of uterine myoma of 10 years evolution and bilateral salpingectomy due to endometriosis. She was studied because of abdominal pain located in lower hemiabdomen, as well as hematochezia and diarrhea, these symptoms accompanied by weight loss during the last month. Physical examination showed a good overall appearance, although a rectal examination revealed a friable mass bleeding to the fingertip friction. The blood test showed hemoglobin levels at the lower limit of normal blood. A colonoscopy showed that the lesion was at 8 cm of the anal verge. It was an exophytic and stenotic tumor with malignant appearance. Biopsies revealed that the rectal mucosa was infiltrated by a squamous cell carcinoma. Immunohistochemistry samples showed CK7 positivity and CK20 negativity with overexpression of p16. HPV 16 was detected by PCR technique. At the cervical cytology and the biopsy by uterine curettage no pathological findings were identified. The computed tomography (CT) showed an irregular mass in the middle rectum as well as lymph nodes in the mesorectal fat with pathological appearance and other smaller unspecified periaortic nodes (Fig. 1). The magnetic resonance imaging revealed a bulky mass of 8 cm in length in the middle rectum with infiltrative appearance which invaded the mesorectal fat and fornix vaginal without cleavage plane (T4CRM+N+) (Fig. 2). The case was discussed by a multidisciplinary committee in our center that decided to perform neoadjuvant chemotherapy with cisplatin and neoadjuvant radiotherapy. After 4 months of treatment, the revaluation clinical tests showed a poor response and surgery was planned. The patient underwent a posterior pelvic exenteration with pelvic peritonectomy and intraoperative radiotherapy. The postoperative histopathological findings were a squamous cell carcinoma of rectum moderately differentiated infiltrating the radial margin pT3N1. Immunohistochemistry tests revealed positivity for AE1, AE3, CK7 and overexpressio...

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“…However, the noted association of colorectal ASC with both ulcerative colitis and schistosomiasis suggests that chronic inflammation is a contributing factor [8]. The hypothesis that human papilloma virus can result in the pathogenesis of colorectal ASC has been suggested, but no association was found [6,9].…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Cecum: A Rare but Aggressive Form of Colonic Neoplasia

Abdalla¹,

Cornish²,

Taboada³

et al. 2014

Fam Med Med Sci Res

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Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum?

Cited by 70 publications

References 21 publications

Primary Squamous Cell Carcinoma of the Colon Associated with Hypercalcemia and Hyperleukocytosis

Primary Squamous Cell Carcinoma of the Colon Associated with Hypercalcemia and Hyperleukocytosis

Primary squamous cell carcinoma of the rectum: An atypical histology

Adenosquamous Carcinoma of the Cecum: A Rare but Aggressive Form of Colonic Neoplasia

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