Does hypothyroidism augment sun-induced skin damage?

Bocheva, Georgeta; Valcheva-Traykova, Maria; Landzhov, Boycho

doi:10.1080/13510002.2018.1494421

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…7,37 It has been recently shown that in state of hypothyroidism, the skin has an increased lipid peroxidation due to a decreased antioxidant defense. 38 These changes, together with a decreased level of certain important antioxidant enzymes found in PLE patients, 39 may account in augmented oxidative stress in the skin of PLE patients with hypothyroidism.…”

Section: Sex and Thyroid Hormonesmentioning

confidence: 99%

Immunopathogenesis and management of polymorphic light eruption

Kadurina

Kazandjieva

Bocheva

2021

Dermatologic Therapy

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Polymorphic light eruption (PLE) is the most common immunologically mediated photodermatosis, demonstrating many abnormalities caused by critical failure of ultraviolet (UV)-induced immunosuppression. The unique expression of antimicrobial peptides in PLE, which is most likely determined by alteration of microbiome components upon UV exposure, implicates their possible triggering role and pathogenic significance in the eruption. The review aims to clarify current knowledge

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Section: Sex and Thyroid Hormonesmentioning

confidence: 99%

Immunopathogenesis and management of polymorphic light eruption

Kadurina

Kazandjieva

Bocheva

2021

Dermatologic Therapy

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“…Lipid peroxidation is one of the main steps through which photo-oxidative stress helps in causing photocarcinogenesis and photoaging. [13] Both groups showed significant reduction in DPAS at 4 th and 12 th week follow-up suggesting decrease in signs of photodamage. Majority of the patients reported improvement in skin smoothness, firmness, and complexion with softening of fine lines in both the groups.…”

Section: Discussionmentioning

confidence: 83%

Clinical and dermoscopic evaluation of red light emitting diodes with beta-carotene versus red light emitting diodes alone in treatment of photoaging

Kumar

Kaur

2023

CSDM

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Objectives: Red light-emitting diodes (LEDs) alter the extracellular matrix and increase fibroblast growth factor which increases the number of fibroblasts. Carotenoids have singlet oxygen quenching properties. The objective of this study was to evaluate combined effect of red light with oral beta-carotene in treating photo-damaged skin. Material and Methods: Enrolled subjects were randomized into two groups, A and B. Group A received two sessions/week for 4 weeks of red light therapy and oral beta-carotene 30 mg/day for 12 weeks and Group B received two sessions/week for 4 weeks of red light therapy alone. Before and after clinical as well as dermoscopic photographs were evaluated. Dermoscopic photoaging scale (DPAS), Physician Global Assessment, and Patient Global Assessment was done at baseline, at end of therapy at 4 weeks and at 12 weeks. Results: The mean DPAS of Group A before the treatment was 22.76 which decreased to 10.08 at the end of follow-up period (12 weeks) and was 19.80 in Group B before the treatment which decreased to 10.84. There was 28.25% reduction in DPAS in Group A at 4 weeks whereas it was 16.18% in Group B. Group A showed 56.12% reduction at week 12, while Group B showed 44.78% reduction. There was statistically significant difference in mean percentage reduction in DPAS between the two groups when compared (P = 0.001). Conclusion: Red LED therapy with oral beta-carotene is a better approach for treating photoaging than Red LED therapy alone.

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“…Hypothyroidism was induced in 20 male Wistar albino rats with an average starting body weight of about 210 g by administration of 0.01% 6- n -propyl-2-thiouracil (PTU) (Sigma-Aldrich ® , St. Louis, MO, USA) for 5 weeks in the ad libitum consumed drinking water [ 1 , 21 , 22 ]. After reaching the hypothyroid state, proofed by free T4 (fT4) levels in the serum (measured by chemiluminescent immunoassay), 5 animals were injected intraperitoneally (i.p.)…”

Section: Methodsmentioning

confidence: 99%

“…Hypothyroidism is one of the most common metabolic disorders with varying distribution throughout the world according to local dietary specifics and demographic characteristics. Because of the extensive role of thyroid hormones in the regulation of the metabolism, the symptoms of hypothyroidism are frequently attributed to other diseases [ 1 , 2 ]. Large observational studies and meta-analyses have shown that about 4–7% of community-derived populations in the USA and Europe have undiagnosed hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Hypothyroidism-Induced Cognitive Impairment by Modulating Serotonin Mediation

Bakalov

Iliev

Sabit

et al. 2023

Veterinary Sciences

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Thyroid hormones play an important role in the modeling of neural networks in the brain. Besides its metabolic effects, thyroid dysfunction, and hypothyroidism in particular, is frequently associated with cognitive decline and depressive-like behavior. The current study aimed to examine the changes in behavior, cognition, and memory in rats with propylthiouracil-induced overt hypothyroidism. The behavior and cognition were assessed using the open field test, T-maze, and novel object recognition test. We found significant differences in the behavioral patterns of the hypothyroid animals showing a reduction in locomotor activity, frequency of rearing, and impaired memory function compared to the euthyroid controls. As serotonin is an essential biomarker regulating cognition and mood, we tried to modulate the serotonin mediation in hypothyroid animals through tryptophan administration. Treatment with 5-hydroxy-tryptophan (5-OH-TRP) intraperitoneally for 10 days or directly into the hippocampus as a single injection led to attenuation of the hypothyroidism-induced cognitive and memory decline. A staggering amount of research is suggesting that the common denominators in the pathophysiology of depression and the behavior changes in hypothyroidism are the hippocampal complex and the distorted serotonin metabolism. In our study, it was observed a significant alleviation of cognitive impairment and an improvement of memory performance in hypothyroid rats after 5-OH-TRP administration. Current results are promising and may serve as groundwork for further investigation of functional and structural changes in the hippocampus during a hypothyroid state, and in particular, the effects of serotonin mediation in hypothyroid-associated depressive-like behavior.

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Does hypothyroidism augment sun-induced skin damage?

Abstract: The hypothyroid state could be a risk factor for enhanced oxidative skin damage in chronic photo-exposed skin due to oxidative stress. The lipid peroxidation is one of the major pathways by which photo-oxidative stress promotes photocarcinogenesis and photo-aging.

Cited by 5 publications

References 43 publications

Immunopathogenesis and management of polymorphic light eruption

Immunopathogenesis and management of polymorphic light eruption

Clinical and dermoscopic evaluation of red light emitting diodes with beta-carotene versus red light emitting diodes alone in treatment of photoaging

Attenuation of Hypothyroidism-Induced Cognitive Impairment by Modulating Serotonin Mediation

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