The main aim of this paper is to empirically assess the relationship between macroeconomic indicators, political regime, and corporate responsibility reporting in African countries. Using ex post facto research design, the paper stands out from previous analyses by including other independent variables, such as regulatory quality, rule of law and government effectiveness in assessing the relationship between corporate responsibility reporting, macroeconomic indicators, and political regime. The population comprises 58 African countries, and the sample is based on 48 African countries. Secondary data was employed to gather information on the variables. The study used a multiple regression model to examine the relationship between foreign direct investment, gross domestic product, inflation, political regime, and corporate responsibility reporting in African countries. The study found an insignificant positive relationship between the number of corporate responsibility reports, political regime, foreign direct investment, gross domestic product, and inflation after applying controls for government effectiveness, regulatory quality, and rule of law. The paper assists in understanding the relationship between political regime, macroeconomic indicators, and corporate responsibility reporting in Africa. Also, an understanding of how institutional factors influence corporate responsibility reporting in African countries could help enforcement institutions, such as the stock exchange, industry regulators and key players that monitor corporate, social, and environmental responsibility issues, to take the necessary steps to improve responsibility reporting provided by organizations in Africa. To conclude, the paper makes a unique contribution to the assessment of the relationship between macroeconomic indicators, political regime, and corporate responsibility reporting. Contribution/Originality: This study contributes to the existing literature on corporate responsibility reporting by using a standard regression estimation methodology. It developed a new formula on the relationship between corporate responsibility reporting, macroeconomic indicators, and political regime, while applying controls for country governance indicators, and is one of very few studies which has investigated this relationship in African countries.