Does ischemia-reperfusion injury affect ovarian reserve and follicle viability in a rat model with adnexal torsion?

Çalış, Pınar; Bozdağ, Gürkan; Sökmensüer, Lale Karakoç; Kender, Nergis

doi:10.1016/j.ejogrb.2014.12.006

Cited by 21 publications

(22 citation statements)

References 15 publications

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“…found a decrease in the ovarian follicle numbers after the I/R injury, Kaya et al . identified an increase in the number of ovarian follicles with Enoxaparin after I/R injury . The follicle counts in our study were found to be lower in the group which was exposed to the ovarian damage, and higher in the groups treated with KO, close to the Sham group.…”

Section: Discussionsupporting

confidence: 52%

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What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

Yeral

Sayan

Karaca

et al. 2018

J of Obstet and Gynaecol

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Aim: In this study, we aimed to investigate the protective effect of krill oil (KO) against ischemiareperfusion (I/R) injury on rat ovary. Methods: This study was conducted with 32 Wistar Albino rats. Rats were divided into four groups, with eight rats in each group-as follows: Sham group, I/R group, I/R + low dose KO group (50 mg) and I/R + high dose KO group (500 mg). The histopathological and follicle counts were performed on the right ovary. The total antioxidant status, total oxidant status and oxidative stress index were evaluated on the left ovary. And also serum N-thiol level, serum T-thiol level, serum disulfide (SDS) level, serum disulfide/N-thiol and serum disulfide/T-thiol ratios were evaluated too. Results: A statistically significant difference was determined between the I/R group and all the other groups for all parameters. There was significant difference between KO groups and the Sham group for the parameters of serum N-thiol, serum T-thiol, SDS, serum disulfide/N-thiol and serum disulfide/T-thiol. SDS, total oxidant status and oxidative stress index were determined to be the highest in the I/R group and the lowest in the low dose KO group. The total antioxidant status values were found to be the highest in the high dose KO group and the lowest in the I/R group. Follicle counts and histological injury scores showed no significant difference between Sham and KO groups. Conclusion: This study demonstrated that KO has beneficial effects on decreasing the injury after I/R on rat ovary.

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Section: Discussionsupporting

confidence: 52%

“…Researchers evaluated the protective effect of many substances against I/R injury on ovarian tissue . The protective effect of KO against I/R injury on different tissues was reported with many studies .…”

Section: Introductionmentioning

confidence: 99%

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

Yeral

Sayan

Karaca

et al. 2018

J of Obstet and Gynaecol

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“…Türk E et al [13] found that adnexal torsion and detorsion significantly increased the tissue level of malondialdehyde, superoxide dismutase and reduced glutathione, whereas hypothermia inhibited their production as well the histopathological changes in rats. Calis P et al [14] found only the loss of cohesion to be significantly different by 1.28-fold than control sides (p=0.017) in terms of the means of total tissue damage. Significantly lower PCNA counts were revealed in the 16-hour torsion group only in a rat model with adnexal torsion.…”

Section: Discussionmentioning

confidence: 89%

The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Tsompos¹,

Constantinos²,

Konstantinos³

et al. 2018

Journal of Surgery and Medicine

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“…Despite the necrotic appearance of ovaries, almost no publications have reported an increase in the risk of thromboembolism, regardless of whether or not the ovaries were left detorsioned. Contrary to common belief, the rarity of this complication often leads clinicians to be optimistic; however, long-term follow-ups unexpectedly revealed reperfusion damage (Calis et al 2015).…”

Section: Discussionmentioning

confidence: 95%

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

et al. 2018

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SUMMARY:We aimed to evaluate the effects of detorsion and Allium sativum (garlic oil) treatment on the ovarian reserve in an ovarian torsion model. Ovarian torsion may lead to loss of ovarian tissue and infertility. It is an experimental rat study that was carried out on 16 sets of ovaries each, one for treatment group and a control group. In the control group, the procedure involved only the surgically opening and closing the abdomen. Bilateral adnexal torsion/detorsion was performed after a 3-hour ischemia period for the detorsion-only group. The detorsion + Allium sativum group received a 5 ml/kg dose of Allium sativum intraperitoneally, 2 hours before surgery. After the second surgery, removed ovarian samples were evaluated for follicle counts, damage scores and other parameters. Primordial, preantral, small antral and large antral follicle counts were significantly higher in the detorsion + Allium sativum group. Degeneration, congestion, hemorrhage ,inflammation and total damage scores were significantly elevated in the detorsion only group compared to those for the detorsion + Allium sativum group. Finally, there was a significant correlation between AMH alterations and postoperative, preantral follicle count (p<0.05). As a conclusion detorsion + Allium sativum treatment may be effective in protecting the ovarian reserve after torsion.

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Does ischemia-reperfusion injury affect ovarian reserve and follicle viability in a rat model with adnexal torsion?

Cited by 21 publications

References 15 publications

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

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Does ischemia-reperfusion injury affect ovarian reserve and follicle viability in a rat model with adnexal torsion?

Cited by 21 publications

References 15 publications

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Investigation of Allium sativum&#8217;s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

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Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model